Association between ABCC2 Gene Haplotypes and Tenofovir-Induced Proximal Tubulopathy

BackgroundTenofovir disoproxil fumarate (TDF) may induce renal proximal tubulopathy (rPT). There are no data on pharmacogenomic predictors of rPT in the genes encoding the multidrug-resistance protein (MRP) 2 and MRP4 transporters MethodsMutational screening of the genes for MRP2 (ABCC2) and MRP4 (A...

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Veröffentlicht in:	The Journal of infectious diseases 2006-12, Vol.194 (11), p.1481-1491
Hauptverfasser:	Izzedine, Hassane, Hulot, Jean-Sebastien, Villard, Eric, Goyenvalle, Catherine, Dominguez, Stephanie, Ghosn, Jade, Valantin, Marc Antoine, Lechat, Philippe, Deray, and Gilbert
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - adverse effects Adenine - analogs & derivatives Adult Aged AIDS Alleles Anti-HIV Agents - adverse effects Antivirals Case-Control Studies Exons Fanconi Syndrome - chemically induced Fanconi Syndrome - genetics Female Gene Frequency Genetic mutation Genetic Predisposition to Disease Genotypes Haplotypes HIV 1 HIV Infections - complications HIV Infections - drug therapy HIV/AIDS Human immunodeficiency virus 1 Humans Male Medical genetics Membrane Transport Proteins - genetics Middle Aged Multidrug Resistance-Associated Proteins - genetics Nephrotoxicity Organophosphonates - adverse effects Point Mutation Polymorphism, Single Nucleotide Statistics as Topic Tenofovir
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