Effects of interleukins 2 and 12 on the levels of granzyme B and perforin and their mRNAs in tributyltin-exposed human natural killer cells

Natural killer (NK) cells are a subset of lymphocytes that are capable of killing tumor cells, virally infected cells and antibody coated cells. Tributyltin (TBT) is a toxic chemical used for various industrial purposes such as: slime control in paper mills, disinfection of circulating industrial co...

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Veröffentlicht in:	Archives of toxicology 2005-12, Vol.79 (12), p.711-720
Hauptverfasser:	THOMAS, Leeshawn D, SHAH, Hemangini, BANKHURST, Arthur D, WHALEN, Margaret M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Cells, Cultured Female Gene Expression Regulation - drug effects Granzymes Humans Immune system Interleukin-12 - pharmacology Interleukin-2 - pharmacology K562 Cells Killer Cells, Natural - drug effects Killer Cells, Natural - metabolism Male Medical sciences Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Perforin Pore Forming Cytotoxic Proteins RNA, Messenger - metabolism Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Toxicology Trialkyltin Compounds - toxicity
Online-Zugang:	Volltext
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