Regression of upper gastric cancer in mice by FHIT gene delivery

ABSTRACT Fhit expression is reduced in most cancers, and Fhit replacement by FHIT expression viruses in lung, esophageal, pancreatic, and cervical cancers induces apoptosis in the cancer cells. Mice carrying one or two inactivated Fhit alleles are hypersensitive to development of N‐nitrosomethylbenz...

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Veröffentlicht in:	The FASEB journal 2003-09, Vol.17 (12), p.1768-1770
Hauptverfasser:	Ishii, Hideshi, Zanesi, Nicola, Vecchione, Andrea, Trapasso, Francesco, Yendamuri, Sai, Sarti, Manuela, Baffa, Raffaele, During, Matthew J., Huebner, Kay, Fong, Louise Y.Y., Croce, Carlo M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Anhydride Hydrolases Administration, Oral Animals Apoptosis Bcl2-Bax Cell Division Dimethylnitrosamine - analogs & derivatives FHIT viruses forestomach Gastric Mucosa - pathology Genetic Therapy Genetic Vectors - administration & dosage Mice Models, Biological Neoplasm Proteins - genetics NMBA Stomach - anatomy & histology Stomach - pathology Stomach Neoplasms - chemically induced Stomach Neoplasms - pathology Stomach Neoplasms - therapy tumor reversal Viruses - genetics
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