Complement C5a inhibition moderates lipid metabolism and reduces tubulointerstitial fibrosis in diabetic nephropathy

Complement C5 mediates pro-inflammatory responses in many immune-related renal diseases. Given that the C5a level is elevated in diabetes, we investigated whether activation of C5a/C5aR signalling plays a pathogenic role in diabetic nephropathy (DN) and the therapeutic potential of C5a inhibition fo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nephrology, dialysis, transplantation dialysis, transplantation, 2018-08, Vol.33 (8), p.1323-1332
Hauptverfasser:	Yiu, Wai Han, Li, Rui Xi, Wong, Dickson W L, Wu, Hao Jia, Chan, Kam Wa, Chan, Loretta Y Y, Leung, Joseph C K, Lai, Kar Neng, Sacks, Steven H, Zhou, Wuding, Tang, Sydney C W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aptamers, Nucleotide - pharmacology Complement C5a - antagonists & inhibitors Diabetes Mellitus, Experimental - physiopathology Diabetic Nephropathies - complications Fibrosis - etiology Fibrosis - metabolism Fibrosis - prevention & control Humans Kidney Diseases - etiology Kidney Diseases - metabolism Kidney Diseases - prevention & control Kidney Tubules - drug effects Kidney Tubules - metabolism Kidney Tubules - pathology Lipid Metabolism - drug effects Male Mice Mice, Inbred C57BL Phosphatidylinositol 3-Kinases - metabolism Serine Endopeptidases - pharmacology Signal Transduction - drug effects Transforming Growth Factor beta - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!