Effects of BDNF receptor antagonist on the severity of physical and psychological dependence, morphine-induced locomotor sensitization and the ventral tegmental area-nucleus accumbens BDNF levels in morphine- dependent and withdrawn rats

•ANA-12 exacerbated morphine withdrawal signs in morphine-dependent rats.•ANA-12 partially ameliorated increased anxiety-like behavior in morphine-dependent rats.•ANA-12 did not affect morphine-induced hyperlocomotion after morphine withdrawal.•ANA-12 did not alter the VTA-NAc BDNF levels in morphin...

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Veröffentlicht in:	Neuroscience letters 2018-03, Vol.668, p.7-12
Hauptverfasser:	Khalil-Khalili, Masoumeh, Rashidy-Pour, Ali, Bandegi, Ahmad Reza, Yousefi, Behpoor, Jorjani, Hassan, Miladi-Gorji, Hossein
Format:	Artikel
Sprache:	eng
Schlagworte:	Anxiety BDNF levels BDNF receptor antagonist Locomotor sensitization Morphine dependence
Online-Zugang:	Volltext
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