Early Immunization Induces Persistent Tumor-Infiltrating CD8 super(+) T Cells against an Immunodominant Epitope and Promotes Lifelong Control of Pancreatic Tumor Progression in SV40 Tumor Antigen Transgenic Mice

The ability to recruit the host's CD8 super(+) T lymphocytes (T sub(CD8)) against cancer is often limited by the development of peripheral tolerance toward the dominant tumor-associated Ags. Because multiple epitopes derived from a given tumor Ag (T Ag) can be targeted by T sub(CD8), vaccine ap...

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Veröffentlicht in:	Journal of Immunology 2006-09, Vol.177 (5), p.3089-3099
Hauptverfasser:	Otahal, Pavel, Schell, Todd D, Hutchinson, Sandra C, Knowles, Barbara B, Tevethia, Satvir S
Format:	Artikel
Sprache:	eng
Schlagworte:	Simian virus 40
Online-Zugang:	Volltext
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