Estrogenic and dioxin-like compounds in sediment from Zierikzee harbour identified with CALUX assay-directed fractionation combined with one and two dimensional gas chromatography analyses
The identity of compounds responsible for estrogenic and dioxin-like activities in sediment from the harbour of the small town Zierikzee in Zeeland, The Netherlands, was investigated using a bioassay directed fractionation approach with the in vitro estrogen and dioxin responsive reporter gene assay...
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| Veröffentlicht in: | Chemosphere (Oxford) 2006-12, Vol.65 (11), p.2244-2252 |
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| creator | Houtman, Corine J. Booij, Petra Jover, Eric Pascual del Rio, David Swart, Kees van Velzen, Martin Vreuls, Rene Legler, Juliette Brouwer, Abraham Lamoree, Marja H. |
| description | The identity of compounds responsible for estrogenic and dioxin-like activities in sediment from the harbour of the small town Zierikzee in Zeeland, The Netherlands, was investigated using a bioassay directed fractionation approach with the
in vitro estrogen and dioxin responsive reporter gene assays ER- and DR-CALUX. For identification of compounds exhibiting activity in the bioassays, either one or two-dimensional GC in combination with quadrupole (MSD), ion trap (ITD) or time-of-flight mass spectrometric detection (ToF-MS) was used, depending on the biological and chemical characteristics and the complexity of the fractions. The natural estrogenic hormone 17-β-estradiol and its metabolite estrone were identified with GC–ITD as the main contributors to the estrogenic activity. After successive rounds of fractionation, the dioxin-like activity could be explained by the presence of various polycyclic aromatic hydrocarbons identified with GC–MSD and two-dimensional comprehensive GC
×
GC–ToF-MS. Some estrogenic activity of a relatively non-polar nature remained unidentified. |
| doi_str_mv | 10.1016/j.chemosphere.2006.05.043 |
| format | Article |
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in vitro estrogen and dioxin responsive reporter gene assays ER- and DR-CALUX. For identification of compounds exhibiting activity in the bioassays, either one or two-dimensional GC in combination with quadrupole (MSD), ion trap (ITD) or time-of-flight mass spectrometric detection (ToF-MS) was used, depending on the biological and chemical characteristics and the complexity of the fractions. The natural estrogenic hormone 17-β-estradiol and its metabolite estrone were identified with GC–ITD as the main contributors to the estrogenic activity. After successive rounds of fractionation, the dioxin-like activity could be explained by the presence of various polycyclic aromatic hydrocarbons identified with GC–MSD and two-dimensional comprehensive GC
×
GC–ToF-MS. Some estrogenic activity of a relatively non-polar nature remained unidentified.</description><identifier>ISSN: 0045-6535</identifier><identifier>EISSN: 1879-1298</identifier><identifier>DOI: 10.1016/j.chemosphere.2006.05.043</identifier><identifier>PMID: 16839588</identifier><identifier>CODEN: CMSHAF</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animal, plant and microbial ecology ; Applied ecology ; Bioassay-directed fractionation ; Biological and medical sciences ; Chromatography, Gas - methods ; Chromatography, High Pressure Liquid ; Dioxins - analysis ; Ecotoxicology, biological effects of pollution ; Estrogens - analysis ; Fundamental and applied biological sciences. Psychology ; General aspects ; Geologic Sediments - chemistry ; Hormones ; Polycylic aromatic hydrocarbons ; Sediment ; Toxicity identification and evaluation ; Water Pollutants, Chemical - analysis</subject><ispartof>Chemosphere (Oxford), 2006-12, Vol.65 (11), p.2244-2252</ispartof><rights>2006 Elsevier Ltd</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a459t-9161ba67d3d73caa11759f5603641cd09f95445b33efbdcde99a10285921d13e3</citedby><cites>FETCH-LOGICAL-a459t-9161ba67d3d73caa11759f5603641cd09f95445b33efbdcde99a10285921d13e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.chemosphere.2006.05.043$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18336552$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16839588$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Houtman, Corine J.</creatorcontrib><creatorcontrib>Booij, Petra</creatorcontrib><creatorcontrib>Jover, Eric</creatorcontrib><creatorcontrib>Pascual del Rio, David</creatorcontrib><creatorcontrib>Swart, Kees</creatorcontrib><creatorcontrib>van Velzen, Martin</creatorcontrib><creatorcontrib>Vreuls, Rene</creatorcontrib><creatorcontrib>Legler, Juliette</creatorcontrib><creatorcontrib>Brouwer, Abraham</creatorcontrib><creatorcontrib>Lamoree, Marja H.</creatorcontrib><title>Estrogenic and dioxin-like compounds in sediment from Zierikzee harbour identified with CALUX assay-directed fractionation combined with one and two dimensional gas chromatography analyses</title><title>Chemosphere (Oxford)</title><addtitle>Chemosphere</addtitle><description>The identity of compounds responsible for estrogenic and dioxin-like activities in sediment from the harbour of the small town Zierikzee in Zeeland, The Netherlands, was investigated using a bioassay directed fractionation approach with the
in vitro estrogen and dioxin responsive reporter gene assays ER- and DR-CALUX. For identification of compounds exhibiting activity in the bioassays, either one or two-dimensional GC in combination with quadrupole (MSD), ion trap (ITD) or time-of-flight mass spectrometric detection (ToF-MS) was used, depending on the biological and chemical characteristics and the complexity of the fractions. The natural estrogenic hormone 17-β-estradiol and its metabolite estrone were identified with GC–ITD as the main contributors to the estrogenic activity. After successive rounds of fractionation, the dioxin-like activity could be explained by the presence of various polycyclic aromatic hydrocarbons identified with GC–MSD and two-dimensional comprehensive GC
×
GC–ToF-MS. Some estrogenic activity of a relatively non-polar nature remained unidentified.</description><subject>Animal, plant and microbial ecology</subject><subject>Applied ecology</subject><subject>Bioassay-directed fractionation</subject><subject>Biological and medical sciences</subject><subject>Chromatography, Gas - methods</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Dioxins - analysis</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Estrogens - analysis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>Geologic Sediments - chemistry</subject><subject>Hormones</subject><subject>Polycylic aromatic hydrocarbons</subject><subject>Sediment</subject><subject>Toxicity identification and evaluation</subject><subject>Water Pollutants, Chemical - analysis</subject><issn>0045-6535</issn><issn>1879-1298</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUGP0zAQhS0EYkvhLyBzgFuKHcdJfETVsiCtxIWVEBfLsSeNu4ldPClL97fx43C3RcuRi32Y7808vUfIG85WnPH6_XZlB5gi7gZIsCoZq1dMrlglnpAFbxtV8FK1T8mCsUoWtRTygrxA3DKWxVI9Jxe8boWSbbsgvy9xTnEDwVtqgqPOx18-FKO_BWrjtIv74JD6QBGcnyDMtE9xot89JH97D0AHk7q4T9S7PPS9B0fv_DzQ9Yfrm2_UIJpD4XwCO-dJn4ydfQzm-Bz3dz78FcQADw7mu0gfTuERHOnGILVDPmrmuElmNxwyZsYDAr4kz3ozIrw6_0ty8_Hy6_pTcf3l6nM2UJhKqrlQvOadqRsnXCOsMZw3UvWyZqKuuHVM9UpWleyEgL5z1oFShrOylarkjgsQS_LutHeX4o894KwnjxbG0QSIe9RctRVrcv5Lok6gTRExQa93yU8mHTRn-lid3up_qtPH6jSTOkuz9vX5yL6bwD0qz11l4O0ZMGjNmLMM1uMj1wpRS1lmbn3iIEfyMxel0XoIFk41aBf9f9j5A9_6wv4</recordid><startdate>20061201</startdate><enddate>20061201</enddate><creator>Houtman, Corine J.</creator><creator>Booij, Petra</creator><creator>Jover, Eric</creator><creator>Pascual del Rio, David</creator><creator>Swart, Kees</creator><creator>van Velzen, Martin</creator><creator>Vreuls, Rene</creator><creator>Legler, Juliette</creator><creator>Brouwer, Abraham</creator><creator>Lamoree, Marja H.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QH</scope><scope>7TV</scope><scope>7U7</scope><scope>7UA</scope><scope>C1K</scope><scope>F1W</scope><scope>H96</scope><scope>H97</scope><scope>L.G</scope></search><sort><creationdate>20061201</creationdate><title>Estrogenic and dioxin-like compounds in sediment from Zierikzee harbour identified with CALUX assay-directed fractionation combined with one and two dimensional gas chromatography analyses</title><author>Houtman, Corine J. ; Booij, Petra ; Jover, Eric ; Pascual del Rio, David ; Swart, Kees ; van Velzen, Martin ; Vreuls, Rene ; Legler, Juliette ; Brouwer, Abraham ; Lamoree, Marja H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a459t-9161ba67d3d73caa11759f5603641cd09f95445b33efbdcde99a10285921d13e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animal, plant and microbial ecology</topic><topic>Applied ecology</topic><topic>Bioassay-directed fractionation</topic><topic>Biological and medical sciences</topic><topic>Chromatography, Gas - methods</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Dioxins - analysis</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Estrogens - analysis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>Geologic Sediments - chemistry</topic><topic>Hormones</topic><topic>Polycylic aromatic hydrocarbons</topic><topic>Sediment</topic><topic>Toxicity identification and evaluation</topic><topic>Water Pollutants, Chemical - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Houtman, Corine J.</creatorcontrib><creatorcontrib>Booij, Petra</creatorcontrib><creatorcontrib>Jover, Eric</creatorcontrib><creatorcontrib>Pascual del Rio, David</creatorcontrib><creatorcontrib>Swart, Kees</creatorcontrib><creatorcontrib>van Velzen, Martin</creatorcontrib><creatorcontrib>Vreuls, Rene</creatorcontrib><creatorcontrib>Legler, Juliette</creatorcontrib><creatorcontrib>Brouwer, Abraham</creatorcontrib><creatorcontrib>Lamoree, Marja H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aqualine</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 2: Ocean Technology, Policy & Non-Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>Chemosphere (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Houtman, Corine J.</au><au>Booij, Petra</au><au>Jover, Eric</au><au>Pascual del Rio, David</au><au>Swart, Kees</au><au>van Velzen, Martin</au><au>Vreuls, Rene</au><au>Legler, Juliette</au><au>Brouwer, Abraham</au><au>Lamoree, Marja H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Estrogenic and dioxin-like compounds in sediment from Zierikzee harbour identified with CALUX assay-directed fractionation combined with one and two dimensional gas chromatography analyses</atitle><jtitle>Chemosphere (Oxford)</jtitle><addtitle>Chemosphere</addtitle><date>2006-12-01</date><risdate>2006</risdate><volume>65</volume><issue>11</issue><spage>2244</spage><epage>2252</epage><pages>2244-2252</pages><issn>0045-6535</issn><eissn>1879-1298</eissn><coden>CMSHAF</coden><abstract>The identity of compounds responsible for estrogenic and dioxin-like activities in sediment from the harbour of the small town Zierikzee in Zeeland, The Netherlands, was investigated using a bioassay directed fractionation approach with the
in vitro estrogen and dioxin responsive reporter gene assays ER- and DR-CALUX. For identification of compounds exhibiting activity in the bioassays, either one or two-dimensional GC in combination with quadrupole (MSD), ion trap (ITD) or time-of-flight mass spectrometric detection (ToF-MS) was used, depending on the biological and chemical characteristics and the complexity of the fractions. The natural estrogenic hormone 17-β-estradiol and its metabolite estrone were identified with GC–ITD as the main contributors to the estrogenic activity. After successive rounds of fractionation, the dioxin-like activity could be explained by the presence of various polycyclic aromatic hydrocarbons identified with GC–MSD and two-dimensional comprehensive GC
×
GC–ToF-MS. Some estrogenic activity of a relatively non-polar nature remained unidentified.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>16839588</pmid><doi>10.1016/j.chemosphere.2006.05.043</doi><tpages>9</tpages></addata></record> |
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| ispartof | Chemosphere (Oxford), 2006-12, Vol.65 (11), p.2244-2252 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animal, plant and microbial ecology Applied ecology Bioassay-directed fractionation Biological and medical sciences Chromatography, Gas - methods Chromatography, High Pressure Liquid Dioxins - analysis Ecotoxicology, biological effects of pollution Estrogens - analysis Fundamental and applied biological sciences. Psychology General aspects Geologic Sediments - chemistry Hormones Polycylic aromatic hydrocarbons Sediment Toxicity identification and evaluation Water Pollutants, Chemical - analysis |
| title | Estrogenic and dioxin-like compounds in sediment from Zierikzee harbour identified with CALUX assay-directed fractionation combined with one and two dimensional gas chromatography analyses |
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