Tablet coating by injection molding technology – Optimization of coating formulation attributes and coating process parameters

[Display omitted] We developed and evaluated a solvent-free injection molding (IM) coating technology that could be suitable for continuous manufacturing via incorporation with IM tableting. Coating formulations (coating polymers and plasticizers) were prepared using hot-melt extrusion and screened...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2018-01, Vol.122, p.25-36
Hauptverfasser:	Desai, Parind M., Puri, Vibha, Brancazio, David, Halkude, Bhakti S., Hartman, Jeremy E., Wahane, Aniket V., Martinez, Alexander R., Jensen, Keith D., Harinath, Eranda, Braatz, Richard D., Chun, Jung-Hoon, Trout, Bernhardt L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry, Pharmaceutical - methods Coating Dissolution Drug Carriers - chemistry Drug Liberation - drug effects Excipients - chemistry Hot-melt extrusion Injection molding Injections - methods Melt flow Oxides - chemistry Plasticizers - chemistry Polyethylene - chemistry Polymers - chemistry Solubility - drug effects Stress-strain analysis Tablets - chemistry Technology, Pharmaceutical - methods Temperature
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