A novel role of circadian transcription factor DBP in hippocampal plasticity
In neurons, a variety of extracellular stimuli are capable of inducing transcriptional events that underlie complex processes ranging from learning to disease. The mechanisms linking these long-lasting cellular modifications to behavior remain to be established. Here, we show by microarray analysis...
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| Veröffentlicht in: | Molecular and cellular neuroscience 2006-02, Vol.31 (2), p.303-314 |
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| container_title | Molecular and cellular neuroscience |
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| creator | Klugmann, Matthias Leichtlein, Claudia B. Symes, C. Wymond Klaussner, Bettina C. Brooks, Andrew I. Young, Deborah During, Matthew J. |
| description | In neurons, a variety of extracellular stimuli are capable of inducing transcriptional events that underlie complex processes ranging from learning to disease. The mechanisms linking these long-lasting cellular modifications to behavior remain to be established. Here, we show by microarray analysis that hippocampal activation of glucagon-like peptide-1 receptor (GLP-1R), which is associated with improved learning and neuroprotection, results in suppression of the transcription factor DBP (albumin D-site-binding protein). Recombinant adeno-associated virus (rAAV) based gene expression of DBP in the hippocampus of adult rats caused upregulation of mRNAs encoding constituents of the molecular clock, and the DBP target gene, pyridoxal kinase. Behaviorally, DBP over expression inhibited spatial learning but not memory, and enhanced susceptibility to kainate-induced seizures. This phenotype was paralleled by the activation of MAP kinase in dendritic regions of hippocampal neurons in vivo. These data suggest that DBP may represent an important transcriptional link between GLP-1R activation and neuroplasticity in the hippocampus. |
| doi_str_mv | 10.1016/j.mcn.2005.09.019 |
| format | Article |
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Recombinant adeno-associated virus (rAAV) based gene expression of DBP in the hippocampus of adult rats caused upregulation of mRNAs encoding constituents of the molecular clock, and the DBP target gene, pyridoxal kinase. Behaviorally, DBP over expression inhibited spatial learning but not memory, and enhanced susceptibility to kainate-induced seizures. This phenotype was paralleled by the activation of MAP kinase in dendritic regions of hippocampal neurons in vivo. 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Recombinant adeno-associated virus (rAAV) based gene expression of DBP in the hippocampus of adult rats caused upregulation of mRNAs encoding constituents of the molecular clock, and the DBP target gene, pyridoxal kinase. Behaviorally, DBP over expression inhibited spatial learning but not memory, and enhanced susceptibility to kainate-induced seizures. This phenotype was paralleled by the activation of MAP kinase in dendritic regions of hippocampal neurons in vivo. These data suggest that DBP may represent an important transcriptional link between GLP-1R activation and neuroplasticity in the hippocampus.</description><subject>Adeno-associated virus</subject><subject>Animals</subject><subject>Biological Clocks - physiology</subject><subject>Circadian Rhythm - physiology</subject><subject>Dependovirus - genetics</subject><subject>Dependovirus - metabolism</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Enzyme Activation</subject><subject>Extracellular Signal-Regulated MAP Kinases - metabolism</subject><subject>Glucagon-Like Peptide-1 Receptor</subject><subject>Hippocampus - cytology</subject><subject>Hippocampus - physiology</subject><subject>Kainic Acid - metabolism</subject><subject>Learning - physiology</subject><subject>Memory - physiology</subject><subject>Motor Activity - physiology</subject><subject>Neuronal Plasticity - physiology</subject><subject>Neurons - metabolism</subject><subject>Rats</subject><subject>Receptors, Glucagon - genetics</subject><subject>Receptors, Glucagon - metabolism</subject><subject>Seizures - chemically induced</subject><subject>Signal Transduction - physiology</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Transcription, Genetic</subject><issn>1044-7431</issn><issn>1095-9327</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDtPwzAUhS0EgvL4ASzIE1uCH7HTiKmUp1QJBpgt5-ZauEriYKdI_HtStRIb0z3Dd450P0IuOcs54_pmnXfQ54IxlbMqZ7w6IDPOKpVVUpSH21wUWVlIfkJOU1qzCRSVPCYnXAtVCqFnZLWgffjGlsbQIg2Ogo9gG297OkbbJ4h-GH3oqbMwhkjv796o7-mnH4YAthtsS4fWptGDH3_OyZGzbcKL_T0jH48P78vnbPX69LJcrDKQczFmZQ22VLbGorSASjs5r1FJJaXQGvhcaFVarZjCphJWaXDW1RNYMu20g1qekevd7hDD1wbTaDqfANvW9hg2yfBqLhXXcgL5DoQYUorozBB9Z-OP4cxsFZq1mRSarULDKjMpnDpX-_FN3WHz19g7m4DbHYDTi98eo0ngsQdsfEQYTRP8P_O_y6-CLg</recordid><startdate>20060201</startdate><enddate>20060201</enddate><creator>Klugmann, Matthias</creator><creator>Leichtlein, Claudia B.</creator><creator>Symes, C. 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Here, we show by microarray analysis that hippocampal activation of glucagon-like peptide-1 receptor (GLP-1R), which is associated with improved learning and neuroprotection, results in suppression of the transcription factor DBP (albumin D-site-binding protein). Recombinant adeno-associated virus (rAAV) based gene expression of DBP in the hippocampus of adult rats caused upregulation of mRNAs encoding constituents of the molecular clock, and the DBP target gene, pyridoxal kinase. Behaviorally, DBP over expression inhibited spatial learning but not memory, and enhanced susceptibility to kainate-induced seizures. This phenotype was paralleled by the activation of MAP kinase in dendritic regions of hippocampal neurons in vivo. 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| subjects | Adeno-associated virus Animals Biological Clocks - physiology Circadian Rhythm - physiology Dependovirus - genetics Dependovirus - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Enzyme Activation Extracellular Signal-Regulated MAP Kinases - metabolism Glucagon-Like Peptide-1 Receptor Hippocampus - cytology Hippocampus - physiology Kainic Acid - metabolism Learning - physiology Memory - physiology Motor Activity - physiology Neuronal Plasticity - physiology Neurons - metabolism Rats Receptors, Glucagon - genetics Receptors, Glucagon - metabolism Seizures - chemically induced Signal Transduction - physiology Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic |
| title | A novel role of circadian transcription factor DBP in hippocampal plasticity |
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