Three-year results of ab interno trabeculectomy (Trabectome): Berlin study group
Purpose To assess the long-term outcome of Trabectome surgery in the treatment of primary open angle glaucoma (POAG) and pseudoexfoliative glaucoma (PEX): 3-year results. Methods Trabectome surgery (NeoMedix, Tustin, CA, USA) was performed in 268 POAG patients (women 57.46%, men 42.54%, age 72.35 ± ...
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| Veröffentlicht in: | Graefe's archive for clinical and experimental ophthalmology 2018-03, Vol.256 (3), p.611-619 |
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| creator | Pahlitzsch, Milena Davids, Anja M. Zorn, Malte Torun, Necip Winterhalter, Sibylle Maier, Anna-Karina B. Klamann, Matthias K. Bertelmann, Eckart |
| description | Purpose
To assess the long-term outcome of Trabectome surgery in the treatment of primary open angle glaucoma (POAG) and pseudoexfoliative glaucoma (PEX): 3-year results.
Methods
Trabectome surgery (NeoMedix, Tustin, CA, USA) was performed in 268 POAG patients (women 57.46%, men 42.54%, age 72.35 ± 9.63 years) and 98 PEX glaucoma patients (women 58.16%, men 41.84%, age 73.42 ± 8.54 years), and uncontrolled intraocular pressure (IOP). Parameters were examined preoperatively, 1 day, 6 weeks, 3, 6, 12, 24 and 36 months post surgery. Kaplan-Meier analysis was performed using Criteria A (IOP ≤ 21 mmHg or ≥20% reduction from preoperative IOP), Criteria B (IOP ≤ 18 mmHg or ≥20% IOP reduction), Criteria C (IOP ≤ 21 mmHg, with or without medication) and D (IOP ≤ 18 mmHg, with or without medication). Complete success was defined as IOP ≤ 21 mmHg (Criteria E) and IOP ≤ 18 mmHg without medication (Criteria F).
Results
IOP was reduced from 19.10 ± 4.11 mmHg to 14.27 ± 2.93 mmHg (
p
|
| doi_str_mv | 10.1007/s00417-017-3882-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1983255195</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1983255195</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-d472e449c96ec3706f25f0b2d29f65a6382013ce9491ce2447a3098bb733f2193</originalsourceid><addsrcrecordid>eNp1kE1LwzAYx4Mobr58AC8S8DIP1by1Tbzp8A0GepiwW0jTp7Oja2fSHvrtzewUETyEJOT3_PM8P4TOKLmihKTXnhBB04iExaVkkdxDYyp4HKWELfbRmKSMRpKzxQgdeb8iAecxPUQjppgihIoxep2_O4CoB-OwA99VrcdNgU2Gy7oFVze4dSYD21Vg22bd48n86x7OcHmD78BVZY192-U9Xrqm25ygg8JUHk53-zF6e7ifT5-i2cvj8_R2FlnBZRvlImUghLIqActTkhQsLkjGcqaKJDYJl4xQbkEJRS0wIVLDiZJZlnJeMKr4MZoMuRvXfHTgW70uvYWqMjU0nddUhcHjmKo4oBd_0FXTuTp0t6VYzFQIDRQdKOsa7x0UeuPKtXG9pkRvdetBtw669Va3lqHmfJfcZWvIfyq-_QaADYAPT_US3K-v_039BPCViNI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1982529733</pqid></control><display><type>article</type><title>Three-year results of ab interno trabeculectomy (Trabectome): Berlin study group</title><source>Springer Journals</source><creator>Pahlitzsch, Milena ; Davids, Anja M. ; Zorn, Malte ; Torun, Necip ; Winterhalter, Sibylle ; Maier, Anna-Karina B. ; Klamann, Matthias K. ; Bertelmann, Eckart</creator><creatorcontrib>Pahlitzsch, Milena ; Davids, Anja M. ; Zorn, Malte ; Torun, Necip ; Winterhalter, Sibylle ; Maier, Anna-Karina B. ; Klamann, Matthias K. ; Bertelmann, Eckart</creatorcontrib><description>Purpose
To assess the long-term outcome of Trabectome surgery in the treatment of primary open angle glaucoma (POAG) and pseudoexfoliative glaucoma (PEX): 3-year results.
Methods
Trabectome surgery (NeoMedix, Tustin, CA, USA) was performed in 268 POAG patients (women 57.46%, men 42.54%, age 72.35 ± 9.63 years) and 98 PEX glaucoma patients (women 58.16%, men 41.84%, age 73.42 ± 8.54 years), and uncontrolled intraocular pressure (IOP). Parameters were examined preoperatively, 1 day, 6 weeks, 3, 6, 12, 24 and 36 months post surgery. Kaplan-Meier analysis was performed using Criteria A (IOP ≤ 21 mmHg or ≥20% reduction from preoperative IOP), Criteria B (IOP ≤ 18 mmHg or ≥20% IOP reduction), Criteria C (IOP ≤ 21 mmHg, with or without medication) and D (IOP ≤ 18 mmHg, with or without medication). Complete success was defined as IOP ≤ 21 mmHg (Criteria E) and IOP ≤ 18 mmHg without medication (Criteria F).
Results
IOP was reduced from 19.10 ± 4.11 mmHg to 14.27 ± 2.93 mmHg (
p
< 0.001) and glaucoma medication was decreased from 2.40±0.92 to 1.77±1.00 (
p
< 0.001) in POAG after 36 months. In PEX, IOP decreased from 22.49±9.40 mmHg to 14.57±5.05 mmHg after 36 months (
p
< 0.001). Medications dropped from 2.31±1.02 to 1.75±0.91 (
p
= 0.006). Kaplan-Meier analysis showed a success rate of 80.5% for POAG and 80.8% for PEX using criteria A (
p
= 0.933) and 62.4% for POAG and 73.7% for PEX using criteria B (
p
= 0.147) at 36 months postoperatively. Complete success showed a low survival rate (criteria E-13.5% in POAG and 7.9% in PEX,
p
= 0.070 and criteria F–12.8% in POAG and 5.9% in PEX,
p
= 0.083).
Conclusions
Trabectome is a safe method to lower IOP in patients with POAG and PEX glaucoma in the long-term period. It is beneficial to inform patients prior to surgery about adjuvant glaucoma medication after the surgery.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-017-3882-8</identifier><identifier>PMID: 29290014</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Glaucoma ; Medicine ; Medicine & Public Health ; Ophthalmology ; Success ; Surgery</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2018-03, Vol.256 (3), p.611-619</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2017</rights><rights>Graefe's Archive for Clinical and Experimental Ophthalmology is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-d472e449c96ec3706f25f0b2d29f65a6382013ce9491ce2447a3098bb733f2193</citedby><cites>FETCH-LOGICAL-c438t-d472e449c96ec3706f25f0b2d29f65a6382013ce9491ce2447a3098bb733f2193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00417-017-3882-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00417-017-3882-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29290014$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pahlitzsch, Milena</creatorcontrib><creatorcontrib>Davids, Anja M.</creatorcontrib><creatorcontrib>Zorn, Malte</creatorcontrib><creatorcontrib>Torun, Necip</creatorcontrib><creatorcontrib>Winterhalter, Sibylle</creatorcontrib><creatorcontrib>Maier, Anna-Karina B.</creatorcontrib><creatorcontrib>Klamann, Matthias K.</creatorcontrib><creatorcontrib>Bertelmann, Eckart</creatorcontrib><title>Three-year results of ab interno trabeculectomy (Trabectome): Berlin study group</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Purpose
To assess the long-term outcome of Trabectome surgery in the treatment of primary open angle glaucoma (POAG) and pseudoexfoliative glaucoma (PEX): 3-year results.
Methods
Trabectome surgery (NeoMedix, Tustin, CA, USA) was performed in 268 POAG patients (women 57.46%, men 42.54%, age 72.35 ± 9.63 years) and 98 PEX glaucoma patients (women 58.16%, men 41.84%, age 73.42 ± 8.54 years), and uncontrolled intraocular pressure (IOP). Parameters were examined preoperatively, 1 day, 6 weeks, 3, 6, 12, 24 and 36 months post surgery. Kaplan-Meier analysis was performed using Criteria A (IOP ≤ 21 mmHg or ≥20% reduction from preoperative IOP), Criteria B (IOP ≤ 18 mmHg or ≥20% IOP reduction), Criteria C (IOP ≤ 21 mmHg, with or without medication) and D (IOP ≤ 18 mmHg, with or without medication). Complete success was defined as IOP ≤ 21 mmHg (Criteria E) and IOP ≤ 18 mmHg without medication (Criteria F).
Results
IOP was reduced from 19.10 ± 4.11 mmHg to 14.27 ± 2.93 mmHg (
p
< 0.001) and glaucoma medication was decreased from 2.40±0.92 to 1.77±1.00 (
p
< 0.001) in POAG after 36 months. In PEX, IOP decreased from 22.49±9.40 mmHg to 14.57±5.05 mmHg after 36 months (
p
< 0.001). Medications dropped from 2.31±1.02 to 1.75±0.91 (
p
= 0.006). Kaplan-Meier analysis showed a success rate of 80.5% for POAG and 80.8% for PEX using criteria A (
p
= 0.933) and 62.4% for POAG and 73.7% for PEX using criteria B (
p
= 0.147) at 36 months postoperatively. Complete success showed a low survival rate (criteria E-13.5% in POAG and 7.9% in PEX,
p
= 0.070 and criteria F–12.8% in POAG and 5.9% in PEX,
p
= 0.083).
Conclusions
Trabectome is a safe method to lower IOP in patients with POAG and PEX glaucoma in the long-term period. It is beneficial to inform patients prior to surgery about adjuvant glaucoma medication after the surgery.</description><subject>Glaucoma</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Success</subject><subject>Surgery</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kE1LwzAYx4Mobr58AC8S8DIP1by1Tbzp8A0GepiwW0jTp7Oja2fSHvrtzewUETyEJOT3_PM8P4TOKLmihKTXnhBB04iExaVkkdxDYyp4HKWELfbRmKSMRpKzxQgdeb8iAecxPUQjppgihIoxep2_O4CoB-OwA99VrcdNgU2Gy7oFVze4dSYD21Vg22bd48n86x7OcHmD78BVZY192-U9Xrqm25ygg8JUHk53-zF6e7ifT5-i2cvj8_R2FlnBZRvlImUghLIqActTkhQsLkjGcqaKJDYJl4xQbkEJRS0wIVLDiZJZlnJeMKr4MZoMuRvXfHTgW70uvYWqMjU0nddUhcHjmKo4oBd_0FXTuTp0t6VYzFQIDRQdKOsa7x0UeuPKtXG9pkRvdetBtw669Va3lqHmfJfcZWvIfyq-_QaADYAPT_US3K-v_039BPCViNI</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Pahlitzsch, Milena</creator><creator>Davids, Anja M.</creator><creator>Zorn, Malte</creator><creator>Torun, Necip</creator><creator>Winterhalter, Sibylle</creator><creator>Maier, Anna-Karina B.</creator><creator>Klamann, Matthias K.</creator><creator>Bertelmann, Eckart</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20180301</creationdate><title>Three-year results of ab interno trabeculectomy (Trabectome): Berlin study group</title><author>Pahlitzsch, Milena ; Davids, Anja M. ; Zorn, Malte ; Torun, Necip ; Winterhalter, Sibylle ; Maier, Anna-Karina B. ; Klamann, Matthias K. ; Bertelmann, Eckart</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-d472e449c96ec3706f25f0b2d29f65a6382013ce9491ce2447a3098bb733f2193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Glaucoma</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Success</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pahlitzsch, Milena</creatorcontrib><creatorcontrib>Davids, Anja M.</creatorcontrib><creatorcontrib>Zorn, Malte</creatorcontrib><creatorcontrib>Torun, Necip</creatorcontrib><creatorcontrib>Winterhalter, Sibylle</creatorcontrib><creatorcontrib>Maier, Anna-Karina B.</creatorcontrib><creatorcontrib>Klamann, Matthias K.</creatorcontrib><creatorcontrib>Bertelmann, Eckart</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pahlitzsch, Milena</au><au>Davids, Anja M.</au><au>Zorn, Malte</au><au>Torun, Necip</au><au>Winterhalter, Sibylle</au><au>Maier, Anna-Karina B.</au><au>Klamann, Matthias K.</au><au>Bertelmann, Eckart</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Three-year results of ab interno trabeculectomy (Trabectome): Berlin study group</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><stitle>Graefes Arch Clin Exp Ophthalmol</stitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>256</volume><issue>3</issue><spage>611</spage><epage>619</epage><pages>611-619</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><abstract>Purpose
To assess the long-term outcome of Trabectome surgery in the treatment of primary open angle glaucoma (POAG) and pseudoexfoliative glaucoma (PEX): 3-year results.
Methods
Trabectome surgery (NeoMedix, Tustin, CA, USA) was performed in 268 POAG patients (women 57.46%, men 42.54%, age 72.35 ± 9.63 years) and 98 PEX glaucoma patients (women 58.16%, men 41.84%, age 73.42 ± 8.54 years), and uncontrolled intraocular pressure (IOP). Parameters were examined preoperatively, 1 day, 6 weeks, 3, 6, 12, 24 and 36 months post surgery. Kaplan-Meier analysis was performed using Criteria A (IOP ≤ 21 mmHg or ≥20% reduction from preoperative IOP), Criteria B (IOP ≤ 18 mmHg or ≥20% IOP reduction), Criteria C (IOP ≤ 21 mmHg, with or without medication) and D (IOP ≤ 18 mmHg, with or without medication). Complete success was defined as IOP ≤ 21 mmHg (Criteria E) and IOP ≤ 18 mmHg without medication (Criteria F).
Results
IOP was reduced from 19.10 ± 4.11 mmHg to 14.27 ± 2.93 mmHg (
p
< 0.001) and glaucoma medication was decreased from 2.40±0.92 to 1.77±1.00 (
p
< 0.001) in POAG after 36 months. In PEX, IOP decreased from 22.49±9.40 mmHg to 14.57±5.05 mmHg after 36 months (
p
< 0.001). Medications dropped from 2.31±1.02 to 1.75±0.91 (
p
= 0.006). Kaplan-Meier analysis showed a success rate of 80.5% for POAG and 80.8% for PEX using criteria A (
p
= 0.933) and 62.4% for POAG and 73.7% for PEX using criteria B (
p
= 0.147) at 36 months postoperatively. Complete success showed a low survival rate (criteria E-13.5% in POAG and 7.9% in PEX,
p
= 0.070 and criteria F–12.8% in POAG and 5.9% in PEX,
p
= 0.083).
Conclusions
Trabectome is a safe method to lower IOP in patients with POAG and PEX glaucoma in the long-term period. It is beneficial to inform patients prior to surgery about adjuvant glaucoma medication after the surgery.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>29290014</pmid><doi>10.1007/s00417-017-3882-8</doi><tpages>9</tpages></addata></record> |
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| language | eng |
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| source | Springer Journals |
| subjects | Glaucoma Medicine Medicine & Public Health Ophthalmology Success Surgery |
| title | Three-year results of ab interno trabeculectomy (Trabectome): Berlin study group |
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