Cardiac Hypertrophy in Transgenic Rats Expressing a Dominant-Negative Mutant of the Natriuretic Peptide Receptor B

Natriuretic peptides (NP) mediate their effects by activating membrane-bound guanylyl cyclase-coupled receptors A (NPR-A) or B (NPR-B). Whereas the pathophysiological role of NPR-A has been widely studied, only limited knowledge on the cardiovascular function of NPR-B is available. In vitro studies...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-03, Vol.103 (12), p.4735-4740
Hauptverfasser:	Langenickel, Thomas H., Buttgereit, Jens, Pagel-Langenickel, Ines, Lindner, Maren, Monti, Jan, Beuerlein, Knut, Al-Saadi, Nidal, Plehm, Ralph, Popova, Elena, Tank, Jens, Dietz, Rainer, Willenbrock, Roland, Bader, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Biological Sciences Blood plasma Blood pressure Blood Pressure - genetics Bone Development - genetics Cardiology Cardiomegaly Cardiovascular disease COS cells Cyclic GMP - metabolism Echocardiography Genes, Dominant Genotype & phenotype Guanylate Cyclase - genetics Heart rate Heart Rate - genetics Heart Ventricles - drug effects Heart Ventricles - pathology Heart Ventricles - physiopathology Hypertrophy Hypertrophy, Left Ventricular - genetics Hypertrophy, Left Ventricular - pathology Hypertrophy, Left Ventricular - physiopathology Kidney - physiology Mutation Natriuretic Peptide, C-Type - pharmacology Peptides Rats Receptors Receptors, Atrial Natriuretic Factor - genetics Rodents Sequence Deletion Signal transduction Transgenic animals
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