Detection of Impurities in Organic Crystals by High-Accuracy Terahertz Absorption Spectroscopy
Quantitative detection of impurities in organic crystals was demonstrated by accurately measuring absorption frequencies using a continuous wave gallium phosphide terahertz spectrometer. THz spectra of l-asparagine monohydrate doped with l-aspartic acid at 0.05 to 12.5 wt % were obtained at 10 K. Th...
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| Veröffentlicht in: | Analytical chemistry (Washington) 2018-02, Vol.90 (3), p.1677-1682 |
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| creator | Sasaki, Tetsuo Sakamoto, Tomoaki Otsuka, Makoto |
| description | Quantitative detection of impurities in organic crystals was demonstrated by accurately measuring absorption frequencies using a continuous wave gallium phosphide terahertz spectrometer. THz spectra of l-asparagine monohydrate doped with l-aspartic acid at 0.05 to 12.5 wt % were obtained at 10 K. The three lowest frequency absorption peaks were baseline-resolved, allowing them to be examined independently. Using a least-squares curve fitting technique, impurities were detected at levels as low as 500 ppm. The sensitivity and detection limits of the technique depended strongly on the nature of both the host and the impurities. The projected limit of detection using the current system, given optimal materials, was estimated to be 51.7 ppm. In addition to quantitative assessments, impurities may also be identified by comparing frequency shifts of multiple absorptions. |
| doi_str_mv | 10.1021/acs.analchem.7b03220 |
| format | Article |
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THz spectra of l-asparagine monohydrate doped with l-aspartic acid at 0.05 to 12.5 wt % were obtained at 10 K. The three lowest frequency absorption peaks were baseline-resolved, allowing them to be examined independently. Using a least-squares curve fitting technique, impurities were detected at levels as low as 500 ppm. The sensitivity and detection limits of the technique depended strongly on the nature of both the host and the impurities. The projected limit of detection using the current system, given optimal materials, was estimated to be 51.7 ppm. In addition to quantitative assessments, impurities may also be identified by comparing frequency shifts of multiple absorptions.</description><identifier>ISSN: 0003-2700</identifier><identifier>EISSN: 1520-6882</identifier><identifier>DOI: 10.1021/acs.analchem.7b03220</identifier><identifier>PMID: 29283549</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Absorption rates ; Absorption spectroscopy ; Accuracy ; Asparagine ; Aspartic acid ; Chemistry ; Continuous radiation ; Crystals ; Curve fitting ; Detection limits ; Frequencies ; Gallium phosphides ; Impurities ; Organic crystals ; Spectrum analysis</subject><ispartof>Analytical chemistry (Washington), 2018-02, Vol.90 (3), p.1677-1682</ispartof><rights>Copyright © 2017 American Chemical Society</rights><rights>Copyright American Chemical Society Feb 6, 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a479t-a67cfcbd5cd64a1ba576761e4003123112e6f0d341c23882b5819ae377a1810d3</citedby><cites>FETCH-LOGICAL-a479t-a67cfcbd5cd64a1ba576761e4003123112e6f0d341c23882b5819ae377a1810d3</cites><orcidid>0000-0002-3922-3098</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.analchem.7b03220$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.analchem.7b03220$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29283549$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sasaki, Tetsuo</creatorcontrib><creatorcontrib>Sakamoto, Tomoaki</creatorcontrib><creatorcontrib>Otsuka, Makoto</creatorcontrib><title>Detection of Impurities in Organic Crystals by High-Accuracy Terahertz Absorption Spectroscopy</title><title>Analytical chemistry (Washington)</title><addtitle>Anal. 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In addition to quantitative assessments, impurities may also be identified by comparing frequency shifts of multiple absorptions.</description><subject>Absorption rates</subject><subject>Absorption spectroscopy</subject><subject>Accuracy</subject><subject>Asparagine</subject><subject>Aspartic acid</subject><subject>Chemistry</subject><subject>Continuous radiation</subject><subject>Crystals</subject><subject>Curve fitting</subject><subject>Detection limits</subject><subject>Frequencies</subject><subject>Gallium phosphides</subject><subject>Impurities</subject><subject>Organic crystals</subject><subject>Spectrum analysis</subject><issn>0003-2700</issn><issn>1520-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kDtPwzAUhS0EglL4BwhZYmFJuddxYmesylNC6kBZsRzXoUHNAzsZwq_HpS0DA5OH-51jnY-QC4QJAsMbbfxE13ptVraaiBxixuCAjDBhEKVSskMyAoA4YgLghJx6_wGACJgekxOWMRknPBuRt1vbWdOVTU2bgj5Vbe_KrrSeljWdu3ddl4bO3OA7vfY0H-hj-b6Kpsb0TpuBLqzTK-u6LzrNfePan56XNhS6xpumHc7IURGS9nz3jsnr_d1i9hg9zx-eZtPnSHORdZFOhSlMvkzMMuUac52IVKRoeRiALEZkNi1gGXM0LA7b8kRipm0shEaJ4TAm19ve1jWfvfWdqkpv7Hqta9v0XmEmmeSYQBrQqz_oR9O7INIrBiCl5MBloPiWMmGJd7ZQrSsr7QaFoDb-VfCv9v7Vzn-IXe7K-7yyy9_QXngAYAts4r8f_9v5Dcm0lAw</recordid><startdate>20180206</startdate><enddate>20180206</enddate><creator>Sasaki, Tetsuo</creator><creator>Sakamoto, Tomoaki</creator><creator>Otsuka, Makoto</creator><general>American Chemical Society</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U7</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3922-3098</orcidid></search><sort><creationdate>20180206</creationdate><title>Detection of Impurities in Organic Crystals by High-Accuracy Terahertz Absorption Spectroscopy</title><author>Sasaki, Tetsuo ; Sakamoto, Tomoaki ; Otsuka, Makoto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a479t-a67cfcbd5cd64a1ba576761e4003123112e6f0d341c23882b5819ae377a1810d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Absorption rates</topic><topic>Absorption spectroscopy</topic><topic>Accuracy</topic><topic>Asparagine</topic><topic>Aspartic acid</topic><topic>Chemistry</topic><topic>Continuous radiation</topic><topic>Crystals</topic><topic>Curve fitting</topic><topic>Detection limits</topic><topic>Frequencies</topic><topic>Gallium phosphides</topic><topic>Impurities</topic><topic>Organic crystals</topic><topic>Spectrum analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sasaki, Tetsuo</creatorcontrib><creatorcontrib>Sakamoto, Tomoaki</creatorcontrib><creatorcontrib>Otsuka, Makoto</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Analytical chemistry (Washington)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sasaki, Tetsuo</au><au>Sakamoto, Tomoaki</au><au>Otsuka, Makoto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of Impurities in Organic Crystals by High-Accuracy Terahertz Absorption Spectroscopy</atitle><jtitle>Analytical chemistry (Washington)</jtitle><addtitle>Anal. Chem</addtitle><date>2018-02-06</date><risdate>2018</risdate><volume>90</volume><issue>3</issue><spage>1677</spage><epage>1682</epage><pages>1677-1682</pages><issn>0003-2700</issn><eissn>1520-6882</eissn><abstract>Quantitative detection of impurities in organic crystals was demonstrated by accurately measuring absorption frequencies using a continuous wave gallium phosphide terahertz spectrometer. THz spectra of l-asparagine monohydrate doped with l-aspartic acid at 0.05 to 12.5 wt % were obtained at 10 K. The three lowest frequency absorption peaks were baseline-resolved, allowing them to be examined independently. Using a least-squares curve fitting technique, impurities were detected at levels as low as 500 ppm. The sensitivity and detection limits of the technique depended strongly on the nature of both the host and the impurities. The projected limit of detection using the current system, given optimal materials, was estimated to be 51.7 ppm. 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| source | American Chemical Society Journals |
| subjects | Absorption rates Absorption spectroscopy Accuracy Asparagine Aspartic acid Chemistry Continuous radiation Crystals Curve fitting Detection limits Frequencies Gallium phosphides Impurities Organic crystals Spectrum analysis |
| title | Detection of Impurities in Organic Crystals by High-Accuracy Terahertz Absorption Spectroscopy |
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