Hydrogen postconditioning promotes survival of rat retinal ganglion cells against ischemia/reperfusion injury through the PI3K/Akt pathway

Retinal ischemia/reperfusion injury (IRI) plays a crucial role in the pathophysiology of various ocular diseases. Our previous study have shown that postconditioning with inhaled hydrogen (H2) (HPC) can protect retinal ganglion cells (RGCs) in a rat model of retinal IRI. Our further study aims to in...

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Veröffentlicht in:	Biochemical and biophysical research communications 2018-01, Vol.495 (4), p.2462-2468
Hauptverfasser:	Wu, Jiangchun, Wang, Ruobing, Yang, Dianxu, Tang, Wenbin, Chen, Zeli, Sun, Qinglei, Liu, Lin, Zang, Rongyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Animals Apoptosis Cell Survival Hydrogen Hydrogen - administration & dosage Ischemia/reperfusion Male Phosphatidylinositol 3-Kinases - metabolism PI3K/Akt pathway Postconditioning Proto-Oncogene Proteins c-akt - metabolism Rats, Sprague-Dawley Reperfusion Injury - drug therapy Reperfusion Injury - metabolism Reperfusion Injury - pathology Retinal Ganglion Cells - drug effects Retinal Ganglion Cells - metabolism Retinal Ganglion Cells - pathology Retinal Vessels - drug effects Retinal Vessels - pathology Signal Transduction - drug effects Treatment Outcome
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