Leiomyosarcoma of the head and neck: A 17‐year single institution experience and review of the National Cancer Data Base
Background Leiomyosarcoma is a rare neoplasm of the head and neck. The purpose of this study was to present our single‐institution case series of head and neck leiomyosarcoma and a review of cases in the National Cancer Data Base (NCDB). Methods Patients with head and neck leiomyosarcoma at the Univ...
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| Veröffentlicht in: | Head & neck 2018-04, Vol.40 (4), p.756-762 |
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| creator | Workman, Alan D. Farquhar, Douglas R. Brody, Robert M. Parasher, Arjun K. Carey, Ryan M. Purkey, Michael T. Nagda, Danish A. Brooks, John S. Hartner, Lee P. Brant, Jason A. Newman, Jason G. |
| description | Background
Leiomyosarcoma is a rare neoplasm of the head and neck. The purpose of this study was to present our single‐institution case series of head and neck leiomyosarcoma and a review of cases in the National Cancer Data Base (NCDB).
Methods
Patients with head and neck leiomyosarcoma at the University of Pennsylvania and in the NCDB were identified. Demographic characteristics, tumor factors, treatment paradigms, and outcomes were evaluated for prognostic significance.
Results
Nine patients with head and neck leiomyosarcoma from the institution were identified; a majority had high‐grade disease and cutaneous leiomyosarcoma, with a 5‐year survival rate of 50%. Two hundred fifty‐nine patients with leiomyosarcoma were found in the NCDB; macroscopic positive margins and high‐grade disease were associated with poor prognosis (P < .01), and positive surgical margins were related to adjuvant radiation (P < .001).
Conclusion
Head and neck leiomyosarcoma presents at a high grade and is preferentially treated with surgery. Several demographic and tumor‐specific factors are associated with outcomes and prognosis. |
| doi_str_mv | 10.1002/hed.25054 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1982840201</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1982840201</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3534-a081fe930f65d4416d5fad4df4944415488cd739f37d013620b5035f42816b23</originalsourceid><addsrcrecordid>eNp1kctuEzEUhi0Eom1gwQsgS2zoYtrj21zYlfSGFMGme8sZHxOXmXGwZ1rCikfgGXkSnKbZVOrK9jnf_8nST8g7BicMgJ-u0J5wBUq-IIcMmqoAIauX27sUhYBKHpCjlG4BQJSSvyYHvOF1yWpxSH4v0Id-E5KJbegNDY6OK6QrNJaawdIB2x-f6Bll1b8_fzdoIk1--N4h9UMa_TiNPgwUf60xehxafMhEvPN4v1d9NVvGdHRuMhDpuRkN_WwSviGvnOkSvn08Z-Tm8uJmfl0svl19mZ8tilYoIQsDNXPYCHClslKy0ipnrLRONjI_lazr1laicaKywETJYalAKCd5zcolFzPycaddx_BzwjTq3qcWu84MGKakWVPzWgLP2Rn58AS9DVPMf096u2aqVI3M1PGOamNIKaLT6-h7Ezeagd72oXMf-qGPzL5_NE7LPk_35L6ADJzugHvf4eZ5k76-ON8p_wNIhpLe</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2013156594</pqid></control><display><type>article</type><title>Leiomyosarcoma of the head and neck: A 17‐year single institution experience and review of the National Cancer Data Base</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Workman, Alan D. ; Farquhar, Douglas R. ; Brody, Robert M. ; Parasher, Arjun K. ; Carey, Ryan M. ; Purkey, Michael T. ; Nagda, Danish A. ; Brooks, John S. ; Hartner, Lee P. ; Brant, Jason A. ; Newman, Jason G.</creator><creatorcontrib>Workman, Alan D. ; Farquhar, Douglas R. ; Brody, Robert M. ; Parasher, Arjun K. ; Carey, Ryan M. ; Purkey, Michael T. ; Nagda, Danish A. ; Brooks, John S. ; Hartner, Lee P. ; Brant, Jason A. ; Newman, Jason G.</creatorcontrib><description>Background
Leiomyosarcoma is a rare neoplasm of the head and neck. The purpose of this study was to present our single‐institution case series of head and neck leiomyosarcoma and a review of cases in the National Cancer Data Base (NCDB).
Methods
Patients with head and neck leiomyosarcoma at the University of Pennsylvania and in the NCDB were identified. Demographic characteristics, tumor factors, treatment paradigms, and outcomes were evaluated for prognostic significance.
Results
Nine patients with head and neck leiomyosarcoma from the institution were identified; a majority had high‐grade disease and cutaneous leiomyosarcoma, with a 5‐year survival rate of 50%. Two hundred fifty‐nine patients with leiomyosarcoma were found in the NCDB; macroscopic positive margins and high‐grade disease were associated with poor prognosis (P < .01), and positive surgical margins were related to adjuvant radiation (P < .001).
Conclusion
Head and neck leiomyosarcoma presents at a high grade and is preferentially treated with surgery. Several demographic and tumor‐specific factors are associated with outcomes and prognosis.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.25054</identifier><identifier>PMID: 29286183</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Cohort Studies ; Databases, Factual ; Disease-Free Survival ; Female ; Head ; head and neck ; Head and Neck Neoplasms - diagnostic imaging ; Head and Neck Neoplasms - mortality ; Head and Neck Neoplasms - pathology ; Head and Neck Neoplasms - therapy ; Hospitals, University ; Humans ; Kaplan-Meier Estimate ; leiomyosarcoma ; Leiomyosarcoma - diagnostic imaging ; Leiomyosarcoma - mortality ; Leiomyosarcoma - pathology ; Leiomyosarcoma - therapy ; Male ; Medical prognosis ; Middle Aged ; National Cancer Data Base ; Neck ; Neck Dissection - methods ; Neoplasm Invasiveness - pathology ; Neoplasm Recurrence, Local - mortality ; Neoplasm Recurrence, Local - pathology ; Neoplasm Recurrence, Local - therapy ; Neoplasm Staging ; outcomes ; Pennsylvania ; Prognosis ; Proportional Hazards Models ; Radiotherapy, Adjuvant ; Retrospective Studies ; Risk Assessment ; Surgery ; Survival Analysis ; treatment strategies</subject><ispartof>Head & neck, 2018-04, Vol.40 (4), p.756-762</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3534-a081fe930f65d4416d5fad4df4944415488cd739f37d013620b5035f42816b23</citedby><cites>FETCH-LOGICAL-c3534-a081fe930f65d4416d5fad4df4944415488cd739f37d013620b5035f42816b23</cites><orcidid>0000-0001-9573-6472</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.25054$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.25054$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27931,27932,45581,45582</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29286183$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Workman, Alan D.</creatorcontrib><creatorcontrib>Farquhar, Douglas R.</creatorcontrib><creatorcontrib>Brody, Robert M.</creatorcontrib><creatorcontrib>Parasher, Arjun K.</creatorcontrib><creatorcontrib>Carey, Ryan M.</creatorcontrib><creatorcontrib>Purkey, Michael T.</creatorcontrib><creatorcontrib>Nagda, Danish A.</creatorcontrib><creatorcontrib>Brooks, John S.</creatorcontrib><creatorcontrib>Hartner, Lee P.</creatorcontrib><creatorcontrib>Brant, Jason A.</creatorcontrib><creatorcontrib>Newman, Jason G.</creatorcontrib><title>Leiomyosarcoma of the head and neck: A 17‐year single institution experience and review of the National Cancer Data Base</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
Leiomyosarcoma is a rare neoplasm of the head and neck. The purpose of this study was to present our single‐institution case series of head and neck leiomyosarcoma and a review of cases in the National Cancer Data Base (NCDB).
Methods
Patients with head and neck leiomyosarcoma at the University of Pennsylvania and in the NCDB were identified. Demographic characteristics, tumor factors, treatment paradigms, and outcomes were evaluated for prognostic significance.
Results
Nine patients with head and neck leiomyosarcoma from the institution were identified; a majority had high‐grade disease and cutaneous leiomyosarcoma, with a 5‐year survival rate of 50%. Two hundred fifty‐nine patients with leiomyosarcoma were found in the NCDB; macroscopic positive margins and high‐grade disease were associated with poor prognosis (P < .01), and positive surgical margins were related to adjuvant radiation (P < .001).
Conclusion
Head and neck leiomyosarcoma presents at a high grade and is preferentially treated with surgery. Several demographic and tumor‐specific factors are associated with outcomes and prognosis.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cohort Studies</subject><subject>Databases, Factual</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Head</subject><subject>head and neck</subject><subject>Head and Neck Neoplasms - diagnostic imaging</subject><subject>Head and Neck Neoplasms - mortality</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Head and Neck Neoplasms - therapy</subject><subject>Hospitals, University</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>leiomyosarcoma</subject><subject>Leiomyosarcoma - diagnostic imaging</subject><subject>Leiomyosarcoma - mortality</subject><subject>Leiomyosarcoma - pathology</subject><subject>Leiomyosarcoma - therapy</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>National Cancer Data Base</subject><subject>Neck</subject><subject>Neck Dissection - methods</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Neoplasm Recurrence, Local - mortality</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Recurrence, Local - therapy</subject><subject>Neoplasm Staging</subject><subject>outcomes</subject><subject>Pennsylvania</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Radiotherapy, Adjuvant</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Surgery</subject><subject>Survival Analysis</subject><subject>treatment strategies</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctuEzEUhi0Eom1gwQsgS2zoYtrj21zYlfSGFMGme8sZHxOXmXGwZ1rCikfgGXkSnKbZVOrK9jnf_8nST8g7BicMgJ-u0J5wBUq-IIcMmqoAIauX27sUhYBKHpCjlG4BQJSSvyYHvOF1yWpxSH4v0Id-E5KJbegNDY6OK6QrNJaawdIB2x-f6Bll1b8_fzdoIk1--N4h9UMa_TiNPgwUf60xehxafMhEvPN4v1d9NVvGdHRuMhDpuRkN_WwSviGvnOkSvn08Z-Tm8uJmfl0svl19mZ8tilYoIQsDNXPYCHClslKy0ipnrLRONjI_lazr1laicaKywETJYalAKCd5zcolFzPycaddx_BzwjTq3qcWu84MGKakWVPzWgLP2Rn58AS9DVPMf096u2aqVI3M1PGOamNIKaLT6-h7Ezeagd72oXMf-qGPzL5_NE7LPk_35L6ADJzugHvf4eZ5k76-ON8p_wNIhpLe</recordid><startdate>201804</startdate><enddate>201804</enddate><creator>Workman, Alan D.</creator><creator>Farquhar, Douglas R.</creator><creator>Brody, Robert M.</creator><creator>Parasher, Arjun K.</creator><creator>Carey, Ryan M.</creator><creator>Purkey, Michael T.</creator><creator>Nagda, Danish A.</creator><creator>Brooks, John S.</creator><creator>Hartner, Lee P.</creator><creator>Brant, Jason A.</creator><creator>Newman, Jason G.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9573-6472</orcidid></search><sort><creationdate>201804</creationdate><title>Leiomyosarcoma of the head and neck: A 17‐year single institution experience and review of the National Cancer Data Base</title><author>Workman, Alan D. ; Farquhar, Douglas R. ; Brody, Robert M. ; Parasher, Arjun K. ; Carey, Ryan M. ; Purkey, Michael T. ; Nagda, Danish A. ; Brooks, John S. ; Hartner, Lee P. ; Brant, Jason A. ; Newman, Jason G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3534-a081fe930f65d4416d5fad4df4944415488cd739f37d013620b5035f42816b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cohort Studies</topic><topic>Databases, Factual</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Head</topic><topic>head and neck</topic><topic>Head and Neck Neoplasms - diagnostic imaging</topic><topic>Head and Neck Neoplasms - mortality</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Head and Neck Neoplasms - therapy</topic><topic>Hospitals, University</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>leiomyosarcoma</topic><topic>Leiomyosarcoma - diagnostic imaging</topic><topic>Leiomyosarcoma - mortality</topic><topic>Leiomyosarcoma - pathology</topic><topic>Leiomyosarcoma - therapy</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>National Cancer Data Base</topic><topic>Neck</topic><topic>Neck Dissection - methods</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Neoplasm Recurrence, Local - mortality</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Recurrence, Local - therapy</topic><topic>Neoplasm Staging</topic><topic>outcomes</topic><topic>Pennsylvania</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Radiotherapy, Adjuvant</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Surgery</topic><topic>Survival Analysis</topic><topic>treatment strategies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Workman, Alan D.</creatorcontrib><creatorcontrib>Farquhar, Douglas R.</creatorcontrib><creatorcontrib>Brody, Robert M.</creatorcontrib><creatorcontrib>Parasher, Arjun K.</creatorcontrib><creatorcontrib>Carey, Ryan M.</creatorcontrib><creatorcontrib>Purkey, Michael T.</creatorcontrib><creatorcontrib>Nagda, Danish A.</creatorcontrib><creatorcontrib>Brooks, John S.</creatorcontrib><creatorcontrib>Hartner, Lee P.</creatorcontrib><creatorcontrib>Brant, Jason A.</creatorcontrib><creatorcontrib>Newman, Jason G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Workman, Alan D.</au><au>Farquhar, Douglas R.</au><au>Brody, Robert M.</au><au>Parasher, Arjun K.</au><au>Carey, Ryan M.</au><au>Purkey, Michael T.</au><au>Nagda, Danish A.</au><au>Brooks, John S.</au><au>Hartner, Lee P.</au><au>Brant, Jason A.</au><au>Newman, Jason G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leiomyosarcoma of the head and neck: A 17‐year single institution experience and review of the National Cancer Data Base</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2018-04</date><risdate>2018</risdate><volume>40</volume><issue>4</issue><spage>756</spage><epage>762</epage><pages>756-762</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
Leiomyosarcoma is a rare neoplasm of the head and neck. The purpose of this study was to present our single‐institution case series of head and neck leiomyosarcoma and a review of cases in the National Cancer Data Base (NCDB).
Methods
Patients with head and neck leiomyosarcoma at the University of Pennsylvania and in the NCDB were identified. Demographic characteristics, tumor factors, treatment paradigms, and outcomes were evaluated for prognostic significance.
Results
Nine patients with head and neck leiomyosarcoma from the institution were identified; a majority had high‐grade disease and cutaneous leiomyosarcoma, with a 5‐year survival rate of 50%. Two hundred fifty‐nine patients with leiomyosarcoma were found in the NCDB; macroscopic positive margins and high‐grade disease were associated with poor prognosis (P < .01), and positive surgical margins were related to adjuvant radiation (P < .001).
Conclusion
Head and neck leiomyosarcoma presents at a high grade and is preferentially treated with surgery. Several demographic and tumor‐specific factors are associated with outcomes and prognosis.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29286183</pmid><doi>10.1002/hed.25054</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-9573-6472</orcidid></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Cohort Studies Databases, Factual Disease-Free Survival Female Head head and neck Head and Neck Neoplasms - diagnostic imaging Head and Neck Neoplasms - mortality Head and Neck Neoplasms - pathology Head and Neck Neoplasms - therapy Hospitals, University Humans Kaplan-Meier Estimate leiomyosarcoma Leiomyosarcoma - diagnostic imaging Leiomyosarcoma - mortality Leiomyosarcoma - pathology Leiomyosarcoma - therapy Male Medical prognosis Middle Aged National Cancer Data Base Neck Neck Dissection - methods Neoplasm Invasiveness - pathology Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - therapy Neoplasm Staging outcomes Pennsylvania Prognosis Proportional Hazards Models Radiotherapy, Adjuvant Retrospective Studies Risk Assessment Surgery Survival Analysis treatment strategies |
| title | Leiomyosarcoma of the head and neck: A 17‐year single institution experience and review of the National Cancer Data Base |
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