Suppression of aortic expansion and contractile recovery in a rat abdominal aortic aneurysm model by biodegradable gelatin hydrogel sheet incorporating basic fibroblast growth factor
Biodegradable gelatin hydrogel sheet (BGHS) incorporating basic fibroblast growth factor (bFGF) may inhibit the progression of abdominal aortic aneurysm (AAA). We investigated whether AAA in a rat model treated with BGHS soaked with bFGF can suppress aortic expansion and recover the contractile resp...
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| Veröffentlicht in: | Heart and vessels 2018-07, Vol.33 (7), p.793-801 |
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| creator | Kawai, Norikazu Iwata, Hisashi Shimabukuro, Katsuya Ishida, Narihiro Ogura, Hiroki Umeda, Etsuji Doi, Kiyoshi |
| description | Biodegradable gelatin hydrogel sheet (BGHS) incorporating basic fibroblast growth factor (bFGF) may inhibit the progression of abdominal aortic aneurysm (AAA). We investigated whether AAA in a rat model treated with BGHS soaked with bFGF can suppress aortic expansion and recover the contractile response of aneurysmal aortic wall. Experimental AAA was induced in 10-week-old male Sprague–Dawley rats with intra-aortic elastase infusion. Aortas of these rats were assigned to 4 groups (
n
= 6 each) as follows: Control group, aortas infused with saline; Elastase only group, aortas infused with elastase; Hydrogel group, aortas wrapped with saline-soaked BGHS after elastase infusion; and bFGF group, aortas wrapped with bFGF (100 μg)-soaked BGHS after elastase infusion. Preoperatively and on postoperative day (POD)7 and POD14, mean aortic maximal diameter was measured ultrasonographically. Aortic expansion ratio was calculated as: (post-infusion aortic diameter on POD14/pre-infusion aortic diameter × 100). Aortas were stained with Elastica van Gieson and α-smooth muscle actin to measure the ratio of elastic fibers and α-smooth muscle actin-positive cells area to the media area. Aortas on POD14 were cut into 2-mm rings and treated with contractile agent, then tension was recorded using myography. Maximum aorta diameters were significantly greater in Elastase only group, Hydrogel group, and bFGF group than in Control group (on POD14). Maximum diameter was significantly lower in bFGF group (3.52 ± 0.4 mm) than in Elastase only group (6.21 ± 1.4 mm on POD14,
P
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| doi_str_mv | 10.1007/s00380-017-1114-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1982840158</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1982840158</sourcerecordid><originalsourceid>FETCH-LOGICAL-c396t-c9f9e226c66024a490f4e44af16d532f13bc641c333585384dd0ce401def8fd83</originalsourceid><addsrcrecordid>eNp1kctu1DAYhS0EokPhAdggS2zYBHxJPPESVdAiVWIBrC3H_p1JlcTht0PJi_F8eDotQkisfDnfOb4cQl5y9pYztn-XGJMtqxjfV5zzumKPyI4r3lSi2cvHZMc0Z1Urxf6MPEvphjHeaK6fkjOhRds0Su3Iry_rsiCkNMSZxkBtxDw4Cj8XO9_t2dlTF-eM1uVhBIrg4g_AjQ5Fo2gztZ2P0zDb8cFsZ1hxSxOdooeRdhvthjLr0XrblYgeRpuL_bB5jGVB0wEgl0AXcYl41Hra2VSiwtBh7EabMu0x3uYDDeUeEZ-TJ8GOCV7cj-fk28cPXy-uquvPl58u3l9XTmqVK6eDBiGUU4qJ2taahRrq2gaufCNF4LJzquZOStm0jWxr75mDmnEPoQ2-lefkzSl3wfh9hZTNNCQH41jeGNdkuG5FW_jmiL7-B72JK5ZvuaO4VLp0VCh-ohzGlBCCWXCYLG6GM3Ms1ZxKNaVUcyzVsOJ5dZ-8dhP4P46HFgsgTkAq0twD_nX0f1N_AyhEsQI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1981369111</pqid></control><display><type>article</type><title>Suppression of aortic expansion and contractile recovery in a rat abdominal aortic aneurysm model by biodegradable gelatin hydrogel sheet incorporating basic fibroblast growth factor</title><source>SpringerLink Journals - AutoHoldings</source><creator>Kawai, Norikazu ; Iwata, Hisashi ; Shimabukuro, Katsuya ; Ishida, Narihiro ; Ogura, Hiroki ; Umeda, Etsuji ; Doi, Kiyoshi</creator><creatorcontrib>Kawai, Norikazu ; Iwata, Hisashi ; Shimabukuro, Katsuya ; Ishida, Narihiro ; Ogura, Hiroki ; Umeda, Etsuji ; Doi, Kiyoshi</creatorcontrib><description>Biodegradable gelatin hydrogel sheet (BGHS) incorporating basic fibroblast growth factor (bFGF) may inhibit the progression of abdominal aortic aneurysm (AAA). We investigated whether AAA in a rat model treated with BGHS soaked with bFGF can suppress aortic expansion and recover the contractile response of aneurysmal aortic wall. Experimental AAA was induced in 10-week-old male Sprague–Dawley rats with intra-aortic elastase infusion. Aortas of these rats were assigned to 4 groups (
n
= 6 each) as follows: Control group, aortas infused with saline; Elastase only group, aortas infused with elastase; Hydrogel group, aortas wrapped with saline-soaked BGHS after elastase infusion; and bFGF group, aortas wrapped with bFGF (100 μg)-soaked BGHS after elastase infusion. Preoperatively and on postoperative day (POD)7 and POD14, mean aortic maximal diameter was measured ultrasonographically. Aortic expansion ratio was calculated as: (post-infusion aortic diameter on POD14/pre-infusion aortic diameter × 100). Aortas were stained with Elastica van Gieson and α-smooth muscle actin to measure the ratio of elastic fibers and α-smooth muscle actin-positive cells area to the media area. Aortas on POD14 were cut into 2-mm rings and treated with contractile agent, then tension was recorded using myography. Maximum aorta diameters were significantly greater in Elastase only group, Hydrogel group, and bFGF group than in Control group (on POD14). Maximum diameter was significantly lower in bFGF group (3.52 ± 0.4 mm) than in Elastase only group (6.21 ± 1.4 mm on POD14,
P
< .05). On histological analysis, ratio of the area staining positively for elastic fibers was significantly greater in bFGF group (7.43 ± 1.8%) than in Elastase only group (3.76 ± 2.9%,
P
< .05). The ratio for α-smooth muscle actin-positive cells was significantly lower in Elastase only group (38.3 ± 5.1%) than in Control group (49.8 ± 6.7%,
P
< .05). No significant differences were seen between Elastase only group and bFGF group, but ratios tended to be increased in bFGF group. Consecutive mean contractile tensions were significantly higher in bFGF group than in Elastase only group. Maximum contractile tension was significantly higher in bFGF group (1.3 ± 0.4 mN) than in Elastase only group (0.4 ± 0.2 mN,
P
< .05). Aortic expansion can be suppressed and contractile responses of aneurysmal aortic wall recovered using BGHS incorporating bFGF.</description><identifier>ISSN: 0910-8327</identifier><identifier>EISSN: 1615-2573</identifier><identifier>DOI: 10.1007/s00380-017-1114-0</identifier><identifier>PMID: 29285566</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Actin ; Aneurysms ; Aorta ; Aortic aneurysms ; Biodegradability ; Biodegradation ; Biomedical Engineering and Bioengineering ; Cardiac Surgery ; Cardiology ; Elastase ; Expansion ; Fibroblast growth factor 2 ; Fibroblasts ; Gelatin ; Growth factors ; Hydrogels ; Medicine ; Medicine & Public Health ; Muscle contraction ; Muscles ; Original Article ; Rats ; Rodents ; Smooth muscle ; Tension ; Vascular Surgery</subject><ispartof>Heart and vessels, 2018-07, Vol.33 (7), p.793-801</ispartof><rights>Springer Japan KK, part of Springer Nature 2017</rights><rights>Heart and Vessels is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-c9f9e226c66024a490f4e44af16d532f13bc641c333585384dd0ce401def8fd83</citedby><cites>FETCH-LOGICAL-c396t-c9f9e226c66024a490f4e44af16d532f13bc641c333585384dd0ce401def8fd83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00380-017-1114-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00380-017-1114-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29285566$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawai, Norikazu</creatorcontrib><creatorcontrib>Iwata, Hisashi</creatorcontrib><creatorcontrib>Shimabukuro, Katsuya</creatorcontrib><creatorcontrib>Ishida, Narihiro</creatorcontrib><creatorcontrib>Ogura, Hiroki</creatorcontrib><creatorcontrib>Umeda, Etsuji</creatorcontrib><creatorcontrib>Doi, Kiyoshi</creatorcontrib><title>Suppression of aortic expansion and contractile recovery in a rat abdominal aortic aneurysm model by biodegradable gelatin hydrogel sheet incorporating basic fibroblast growth factor</title><title>Heart and vessels</title><addtitle>Heart Vessels</addtitle><addtitle>Heart Vessels</addtitle><description>Biodegradable gelatin hydrogel sheet (BGHS) incorporating basic fibroblast growth factor (bFGF) may inhibit the progression of abdominal aortic aneurysm (AAA). We investigated whether AAA in a rat model treated with BGHS soaked with bFGF can suppress aortic expansion and recover the contractile response of aneurysmal aortic wall. Experimental AAA was induced in 10-week-old male Sprague–Dawley rats with intra-aortic elastase infusion. Aortas of these rats were assigned to 4 groups (
n
= 6 each) as follows: Control group, aortas infused with saline; Elastase only group, aortas infused with elastase; Hydrogel group, aortas wrapped with saline-soaked BGHS after elastase infusion; and bFGF group, aortas wrapped with bFGF (100 μg)-soaked BGHS after elastase infusion. Preoperatively and on postoperative day (POD)7 and POD14, mean aortic maximal diameter was measured ultrasonographically. Aortic expansion ratio was calculated as: (post-infusion aortic diameter on POD14/pre-infusion aortic diameter × 100). Aortas were stained with Elastica van Gieson and α-smooth muscle actin to measure the ratio of elastic fibers and α-smooth muscle actin-positive cells area to the media area. Aortas on POD14 were cut into 2-mm rings and treated with contractile agent, then tension was recorded using myography. Maximum aorta diameters were significantly greater in Elastase only group, Hydrogel group, and bFGF group than in Control group (on POD14). Maximum diameter was significantly lower in bFGF group (3.52 ± 0.4 mm) than in Elastase only group (6.21 ± 1.4 mm on POD14,
P
< .05). On histological analysis, ratio of the area staining positively for elastic fibers was significantly greater in bFGF group (7.43 ± 1.8%) than in Elastase only group (3.76 ± 2.9%,
P
< .05). The ratio for α-smooth muscle actin-positive cells was significantly lower in Elastase only group (38.3 ± 5.1%) than in Control group (49.8 ± 6.7%,
P
< .05). No significant differences were seen between Elastase only group and bFGF group, but ratios tended to be increased in bFGF group. Consecutive mean contractile tensions were significantly higher in bFGF group than in Elastase only group. Maximum contractile tension was significantly higher in bFGF group (1.3 ± 0.4 mN) than in Elastase only group (0.4 ± 0.2 mN,
P
< .05). Aortic expansion can be suppressed and contractile responses of aneurysmal aortic wall recovered using BGHS incorporating bFGF.</description><subject>Actin</subject><subject>Aneurysms</subject><subject>Aorta</subject><subject>Aortic aneurysms</subject><subject>Biodegradability</subject><subject>Biodegradation</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Cardiac Surgery</subject><subject>Cardiology</subject><subject>Elastase</subject><subject>Expansion</subject><subject>Fibroblast growth factor 2</subject><subject>Fibroblasts</subject><subject>Gelatin</subject><subject>Growth factors</subject><subject>Hydrogels</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Muscle contraction</subject><subject>Muscles</subject><subject>Original Article</subject><subject>Rats</subject><subject>Rodents</subject><subject>Smooth muscle</subject><subject>Tension</subject><subject>Vascular Surgery</subject><issn>0910-8327</issn><issn>1615-2573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kctu1DAYhS0EokPhAdggS2zYBHxJPPESVdAiVWIBrC3H_p1JlcTht0PJi_F8eDotQkisfDnfOb4cQl5y9pYztn-XGJMtqxjfV5zzumKPyI4r3lSi2cvHZMc0Z1Urxf6MPEvphjHeaK6fkjOhRds0Su3Iry_rsiCkNMSZxkBtxDw4Cj8XO9_t2dlTF-eM1uVhBIrg4g_AjQ5Fo2gztZ2P0zDb8cFsZ1hxSxOdooeRdhvthjLr0XrblYgeRpuL_bB5jGVB0wEgl0AXcYl41Hra2VSiwtBh7EabMu0x3uYDDeUeEZ-TJ8GOCV7cj-fk28cPXy-uquvPl58u3l9XTmqVK6eDBiGUU4qJ2taahRrq2gaufCNF4LJzquZOStm0jWxr75mDmnEPoQ2-lefkzSl3wfh9hZTNNCQH41jeGNdkuG5FW_jmiL7-B72JK5ZvuaO4VLp0VCh-ohzGlBCCWXCYLG6GM3Ms1ZxKNaVUcyzVsOJ5dZ-8dhP4P46HFgsgTkAq0twD_nX0f1N_AyhEsQI</recordid><startdate>20180701</startdate><enddate>20180701</enddate><creator>Kawai, Norikazu</creator><creator>Iwata, Hisashi</creator><creator>Shimabukuro, Katsuya</creator><creator>Ishida, Narihiro</creator><creator>Ogura, Hiroki</creator><creator>Umeda, Etsuji</creator><creator>Doi, Kiyoshi</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20180701</creationdate><title>Suppression of aortic expansion and contractile recovery in a rat abdominal aortic aneurysm model by biodegradable gelatin hydrogel sheet incorporating basic fibroblast growth factor</title><author>Kawai, Norikazu ; Iwata, Hisashi ; Shimabukuro, Katsuya ; Ishida, Narihiro ; Ogura, Hiroki ; Umeda, Etsuji ; Doi, Kiyoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-c9f9e226c66024a490f4e44af16d532f13bc641c333585384dd0ce401def8fd83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Actin</topic><topic>Aneurysms</topic><topic>Aorta</topic><topic>Aortic aneurysms</topic><topic>Biodegradability</topic><topic>Biodegradation</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Cardiac Surgery</topic><topic>Cardiology</topic><topic>Elastase</topic><topic>Expansion</topic><topic>Fibroblast growth factor 2</topic><topic>Fibroblasts</topic><topic>Gelatin</topic><topic>Growth factors</topic><topic>Hydrogels</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Muscle contraction</topic><topic>Muscles</topic><topic>Original Article</topic><topic>Rats</topic><topic>Rodents</topic><topic>Smooth muscle</topic><topic>Tension</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawai, Norikazu</creatorcontrib><creatorcontrib>Iwata, Hisashi</creatorcontrib><creatorcontrib>Shimabukuro, Katsuya</creatorcontrib><creatorcontrib>Ishida, Narihiro</creatorcontrib><creatorcontrib>Ogura, Hiroki</creatorcontrib><creatorcontrib>Umeda, Etsuji</creatorcontrib><creatorcontrib>Doi, Kiyoshi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Heart and vessels</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawai, Norikazu</au><au>Iwata, Hisashi</au><au>Shimabukuro, Katsuya</au><au>Ishida, Narihiro</au><au>Ogura, Hiroki</au><au>Umeda, Etsuji</au><au>Doi, Kiyoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Suppression of aortic expansion and contractile recovery in a rat abdominal aortic aneurysm model by biodegradable gelatin hydrogel sheet incorporating basic fibroblast growth factor</atitle><jtitle>Heart and vessels</jtitle><stitle>Heart Vessels</stitle><addtitle>Heart Vessels</addtitle><date>2018-07-01</date><risdate>2018</risdate><volume>33</volume><issue>7</issue><spage>793</spage><epage>801</epage><pages>793-801</pages><issn>0910-8327</issn><eissn>1615-2573</eissn><abstract>Biodegradable gelatin hydrogel sheet (BGHS) incorporating basic fibroblast growth factor (bFGF) may inhibit the progression of abdominal aortic aneurysm (AAA). We investigated whether AAA in a rat model treated with BGHS soaked with bFGF can suppress aortic expansion and recover the contractile response of aneurysmal aortic wall. Experimental AAA was induced in 10-week-old male Sprague–Dawley rats with intra-aortic elastase infusion. Aortas of these rats were assigned to 4 groups (
n
= 6 each) as follows: Control group, aortas infused with saline; Elastase only group, aortas infused with elastase; Hydrogel group, aortas wrapped with saline-soaked BGHS after elastase infusion; and bFGF group, aortas wrapped with bFGF (100 μg)-soaked BGHS after elastase infusion. Preoperatively and on postoperative day (POD)7 and POD14, mean aortic maximal diameter was measured ultrasonographically. Aortic expansion ratio was calculated as: (post-infusion aortic diameter on POD14/pre-infusion aortic diameter × 100). Aortas were stained with Elastica van Gieson and α-smooth muscle actin to measure the ratio of elastic fibers and α-smooth muscle actin-positive cells area to the media area. Aortas on POD14 were cut into 2-mm rings and treated with contractile agent, then tension was recorded using myography. Maximum aorta diameters were significantly greater in Elastase only group, Hydrogel group, and bFGF group than in Control group (on POD14). Maximum diameter was significantly lower in bFGF group (3.52 ± 0.4 mm) than in Elastase only group (6.21 ± 1.4 mm on POD14,
P
< .05). On histological analysis, ratio of the area staining positively for elastic fibers was significantly greater in bFGF group (7.43 ± 1.8%) than in Elastase only group (3.76 ± 2.9%,
P
< .05). The ratio for α-smooth muscle actin-positive cells was significantly lower in Elastase only group (38.3 ± 5.1%) than in Control group (49.8 ± 6.7%,
P
< .05). No significant differences were seen between Elastase only group and bFGF group, but ratios tended to be increased in bFGF group. Consecutive mean contractile tensions were significantly higher in bFGF group than in Elastase only group. Maximum contractile tension was significantly higher in bFGF group (1.3 ± 0.4 mN) than in Elastase only group (0.4 ± 0.2 mN,
P
< .05). Aortic expansion can be suppressed and contractile responses of aneurysmal aortic wall recovered using BGHS incorporating bFGF.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>29285566</pmid><doi>10.1007/s00380-017-1114-0</doi><tpages>9</tpages></addata></record> |
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| ispartof | Heart and vessels, 2018-07, Vol.33 (7), p.793-801 |
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| subjects | Actin Aneurysms Aorta Aortic aneurysms Biodegradability Biodegradation Biomedical Engineering and Bioengineering Cardiac Surgery Cardiology Elastase Expansion Fibroblast growth factor 2 Fibroblasts Gelatin Growth factors Hydrogels Medicine Medicine & Public Health Muscle contraction Muscles Original Article Rats Rodents Smooth muscle Tension Vascular Surgery |
| title | Suppression of aortic expansion and contractile recovery in a rat abdominal aortic aneurysm model by biodegradable gelatin hydrogel sheet incorporating basic fibroblast growth factor |
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