Glomerular Filtration Rate is Unchanged By Ultramarathon
THE MAIN PROBLEM:Acute kidney injury (AKI) is reported as a common complication of marathon and ultramarathon running. In previous studies AKI was diagnosed on the basis of the creatinine level in serum and estimated glomerular filtration rate (eGFR). In the present study we calculated eGFR and also...
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| Veröffentlicht in: | Journal of strength and conditioning research 2018-11, Vol.32 (11), p.3207-3215 |
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| container_title | Journal of strength and conditioning research |
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| creator | Wołyniec, Wojciech Ratkowski, Wojciech Kasprowicz, Katarzyna Jastrzębski, Zbigniew Małgorzewicz, Sylwia Witek, Konrad Grzywacz, Tomasz Żmijewski, Piotr Renke, Marcin |
| description | THE MAIN PROBLEM:Acute kidney injury (AKI) is reported as a common complication of marathon and ultramarathon running. In previous studies AKI was diagnosed on the basis of the creatinine level in serum and estimated glomerular filtration rate (eGFR). In the present study we calculated eGFR and also measured creatinine clearance after every 25 km of a 100 km run. METHODS20 healthy, amateur runners (males, mean age 40.75 ± 7.15 years, mean weight 76.87 ± 8.39 kg) took part in a 100 km run on a track. Blood and urine were collected before the run, after every 25 km and 12 hours after the run. RESULTS17 runners completed the study. There was increase in creatinine, urea and uric acid observed after 100 km (p < 0.05). The mean increase in creatinine was 0.21 mg/dl (24.53%). 5 runners fulfilled the Acute Kidney Injury Network (AKIN) criteria of AKI. The eGFR according to the MDRD (modification of diet in renal disease), CKD-EPI (chronic kidney disease epidemiology collaboration) and Cockcroft-Gault formulas was significantly decreased after the run (p < 0.05). Otherwise, creatinine clearance calculated from creatinine level in both serum and urine remained stable. CONCLUSIONSIn contrast to the majority of previous studies, we did not observe any decrease in the kidney function during an ultramarathon. In this study the creatinine clearance, which is the best routine laboratory method to determine glomerular filtration rate was used. There is no evidence that long running is harmful for kidney. |
| doi_str_mv | 10.1519/JSC.0000000000002348 |
| format | Article |
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In previous studies AKI was diagnosed on the basis of the creatinine level in serum and estimated glomerular filtration rate (eGFR). In the present study we calculated eGFR and also measured creatinine clearance after every 25 km of a 100 km run. METHODS20 healthy, amateur runners (males, mean age 40.75 ± 7.15 years, mean weight 76.87 ± 8.39 kg) took part in a 100 km run on a track. Blood and urine were collected before the run, after every 25 km and 12 hours after the run. RESULTS17 runners completed the study. There was increase in creatinine, urea and uric acid observed after 100 km (p < 0.05). The mean increase in creatinine was 0.21 mg/dl (24.53%). 5 runners fulfilled the Acute Kidney Injury Network (AKIN) criteria of AKI. The eGFR according to the MDRD (modification of diet in renal disease), CKD-EPI (chronic kidney disease epidemiology collaboration) and Cockcroft-Gault formulas was significantly decreased after the run (p < 0.05). Otherwise, creatinine clearance calculated from creatinine level in both serum and urine remained stable. CONCLUSIONSIn contrast to the majority of previous studies, we did not observe any decrease in the kidney function during an ultramarathon. In this study the creatinine clearance, which is the best routine laboratory method to determine glomerular filtration rate was used. There is no evidence that long running is harmful for kidney.</description><identifier>ISSN: 1064-8011</identifier><identifier>EISSN: 1533-4287</identifier><identifier>DOI: 10.1519/JSC.0000000000002348</identifier><identifier>PMID: 29283932</identifier><language>eng</language><publisher>United States: Copyright by the National Strength & Conditioning Association</publisher><subject>Acute Kidney Injury - diagnosis ; Acute Kidney Injury - etiology ; Adult ; Athletes ; Body mass ; Chemical compounds ; Creatinine ; Creatinine - blood ; Creatinine - urine ; Diet ; Epidermal growth factor receptors ; Glomerular Filtration Rate ; Humans ; Kidney diseases ; Kidneys ; Male ; Membrane separation ; Middle Aged ; Running - physiology ; Ultramarathon ; Urea ; Urea - blood ; Urea - urine ; Uric acid ; Uric Acid - blood ; Uric Acid - urine ; Urine</subject><ispartof>Journal of strength and conditioning research, 2018-11, Vol.32 (11), p.3207-3215</ispartof><rights>Copyright © 2017 by the National Strength & Conditioning Association.</rights><rights>Copyright Lippincott Williams & Wilkins Ovid Technologies Nov 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3848-26736afde24733b9dd0f391ec0fb691b333fb9a1c2d0de00ba04cb34e780c0843</citedby><cites>FETCH-LOGICAL-c3848-26736afde24733b9dd0f391ec0fb691b333fb9a1c2d0de00ba04cb34e780c0843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29283932$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wołyniec, Wojciech</creatorcontrib><creatorcontrib>Ratkowski, Wojciech</creatorcontrib><creatorcontrib>Kasprowicz, Katarzyna</creatorcontrib><creatorcontrib>Jastrzębski, Zbigniew</creatorcontrib><creatorcontrib>Małgorzewicz, Sylwia</creatorcontrib><creatorcontrib>Witek, Konrad</creatorcontrib><creatorcontrib>Grzywacz, Tomasz</creatorcontrib><creatorcontrib>Żmijewski, Piotr</creatorcontrib><creatorcontrib>Renke, Marcin</creatorcontrib><title>Glomerular Filtration Rate is Unchanged By Ultramarathon</title><title>Journal of strength and conditioning research</title><addtitle>J Strength Cond Res</addtitle><description>THE MAIN PROBLEM:Acute kidney injury (AKI) is reported as a common complication of marathon and ultramarathon running. In previous studies AKI was diagnosed on the basis of the creatinine level in serum and estimated glomerular filtration rate (eGFR). In the present study we calculated eGFR and also measured creatinine clearance after every 25 km of a 100 km run. METHODS20 healthy, amateur runners (males, mean age 40.75 ± 7.15 years, mean weight 76.87 ± 8.39 kg) took part in a 100 km run on a track. Blood and urine were collected before the run, after every 25 km and 12 hours after the run. RESULTS17 runners completed the study. There was increase in creatinine, urea and uric acid observed after 100 km (p < 0.05). The mean increase in creatinine was 0.21 mg/dl (24.53%). 5 runners fulfilled the Acute Kidney Injury Network (AKIN) criteria of AKI. The eGFR according to the MDRD (modification of diet in renal disease), CKD-EPI (chronic kidney disease epidemiology collaboration) and Cockcroft-Gault formulas was significantly decreased after the run (p < 0.05). Otherwise, creatinine clearance calculated from creatinine level in both serum and urine remained stable. CONCLUSIONSIn contrast to the majority of previous studies, we did not observe any decrease in the kidney function during an ultramarathon. In this study the creatinine clearance, which is the best routine laboratory method to determine glomerular filtration rate was used. There is no evidence that long running is harmful for kidney.</description><subject>Acute Kidney Injury - diagnosis</subject><subject>Acute Kidney Injury - etiology</subject><subject>Adult</subject><subject>Athletes</subject><subject>Body mass</subject><subject>Chemical compounds</subject><subject>Creatinine</subject><subject>Creatinine - blood</subject><subject>Creatinine - urine</subject><subject>Diet</subject><subject>Epidermal growth factor receptors</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Kidney diseases</subject><subject>Kidneys</subject><subject>Male</subject><subject>Membrane separation</subject><subject>Middle Aged</subject><subject>Running - physiology</subject><subject>Ultramarathon</subject><subject>Urea</subject><subject>Urea - blood</subject><subject>Urea - urine</subject><subject>Uric acid</subject><subject>Uric Acid - blood</subject><subject>Uric Acid - urine</subject><subject>Urine</subject><issn>1064-8011</issn><issn>1533-4287</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF9LwzAUxYMobk6_gUjBF186869t8qjDTWUgqHsOaZrazqyZScvYtzdlU2QP3pd74f7u4Z4DwCWCY5Qgfvv8NhnDP4UJZUdgiBJCYopZdhxmmNKYQYQG4Mz7ZWCSJCGnYIA5ZoQTPARsZuxKu85IF01r0zrZ1raJXmWro9pHi0ZVsvnQRXS_jRb9eiUDUtnmHJyU0nh9se8jsJg-vE8e4_nL7GlyN48VYZTFOM1IKstCY5oRkvOigCXhSCtY5ilHOSGkzLlEChew0BDmElKVE6ozBhVklIzAzU537exXp30rVrVX2hjZaNt5gTjrvXCMA3p9gC5t55rwncAoxRlNMOoF6Y5SznrvdCnWrg6utgJB0ScrQrLiMNlwdrUX7_KVLn6PfqIMANsBG2ta7fyn6TbaiUpL01b_a38D5ryC0g</recordid><startdate>20181101</startdate><enddate>20181101</enddate><creator>Wołyniec, Wojciech</creator><creator>Ratkowski, Wojciech</creator><creator>Kasprowicz, Katarzyna</creator><creator>Jastrzębski, Zbigniew</creator><creator>Małgorzewicz, Sylwia</creator><creator>Witek, Konrad</creator><creator>Grzywacz, Tomasz</creator><creator>Żmijewski, Piotr</creator><creator>Renke, Marcin</creator><general>Copyright by the National Strength & Conditioning Association</general><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20181101</creationdate><title>Glomerular Filtration Rate is Unchanged By Ultramarathon</title><author>Wołyniec, Wojciech ; Ratkowski, Wojciech ; Kasprowicz, Katarzyna ; Jastrzębski, Zbigniew ; Małgorzewicz, Sylwia ; Witek, Konrad ; Grzywacz, Tomasz ; Żmijewski, Piotr ; Renke, Marcin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3848-26736afde24733b9dd0f391ec0fb691b333fb9a1c2d0de00ba04cb34e780c0843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Acute Kidney Injury - diagnosis</topic><topic>Acute Kidney Injury - etiology</topic><topic>Adult</topic><topic>Athletes</topic><topic>Body mass</topic><topic>Chemical compounds</topic><topic>Creatinine</topic><topic>Creatinine - blood</topic><topic>Creatinine - urine</topic><topic>Diet</topic><topic>Epidermal growth factor receptors</topic><topic>Glomerular Filtration Rate</topic><topic>Humans</topic><topic>Kidney diseases</topic><topic>Kidneys</topic><topic>Male</topic><topic>Membrane separation</topic><topic>Middle Aged</topic><topic>Running - physiology</topic><topic>Ultramarathon</topic><topic>Urea</topic><topic>Urea - blood</topic><topic>Urea - urine</topic><topic>Uric acid</topic><topic>Uric Acid - blood</topic><topic>Uric Acid - urine</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wołyniec, Wojciech</creatorcontrib><creatorcontrib>Ratkowski, Wojciech</creatorcontrib><creatorcontrib>Kasprowicz, Katarzyna</creatorcontrib><creatorcontrib>Jastrzębski, Zbigniew</creatorcontrib><creatorcontrib>Małgorzewicz, Sylwia</creatorcontrib><creatorcontrib>Witek, Konrad</creatorcontrib><creatorcontrib>Grzywacz, Tomasz</creatorcontrib><creatorcontrib>Żmijewski, Piotr</creatorcontrib><creatorcontrib>Renke, Marcin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of strength and conditioning research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wołyniec, Wojciech</au><au>Ratkowski, Wojciech</au><au>Kasprowicz, Katarzyna</au><au>Jastrzębski, Zbigniew</au><au>Małgorzewicz, Sylwia</au><au>Witek, Konrad</au><au>Grzywacz, Tomasz</au><au>Żmijewski, Piotr</au><au>Renke, Marcin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glomerular Filtration Rate is Unchanged By Ultramarathon</atitle><jtitle>Journal of strength and conditioning research</jtitle><addtitle>J Strength Cond Res</addtitle><date>2018-11-01</date><risdate>2018</risdate><volume>32</volume><issue>11</issue><spage>3207</spage><epage>3215</epage><pages>3207-3215</pages><issn>1064-8011</issn><eissn>1533-4287</eissn><abstract>THE MAIN PROBLEM:Acute kidney injury (AKI) is reported as a common complication of marathon and ultramarathon running. In previous studies AKI was diagnosed on the basis of the creatinine level in serum and estimated glomerular filtration rate (eGFR). In the present study we calculated eGFR and also measured creatinine clearance after every 25 km of a 100 km run. METHODS20 healthy, amateur runners (males, mean age 40.75 ± 7.15 years, mean weight 76.87 ± 8.39 kg) took part in a 100 km run on a track. Blood and urine were collected before the run, after every 25 km and 12 hours after the run. RESULTS17 runners completed the study. There was increase in creatinine, urea and uric acid observed after 100 km (p < 0.05). The mean increase in creatinine was 0.21 mg/dl (24.53%). 5 runners fulfilled the Acute Kidney Injury Network (AKIN) criteria of AKI. The eGFR according to the MDRD (modification of diet in renal disease), CKD-EPI (chronic kidney disease epidemiology collaboration) and Cockcroft-Gault formulas was significantly decreased after the run (p < 0.05). Otherwise, creatinine clearance calculated from creatinine level in both serum and urine remained stable. CONCLUSIONSIn contrast to the majority of previous studies, we did not observe any decrease in the kidney function during an ultramarathon. In this study the creatinine clearance, which is the best routine laboratory method to determine glomerular filtration rate was used. There is no evidence that long running is harmful for kidney.</abstract><cop>United States</cop><pub>Copyright by the National Strength & Conditioning Association</pub><pmid>29283932</pmid><doi>10.1519/JSC.0000000000002348</doi><tpages>9</tpages></addata></record> |
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| subjects | Acute Kidney Injury - diagnosis Acute Kidney Injury - etiology Adult Athletes Body mass Chemical compounds Creatinine Creatinine - blood Creatinine - urine Diet Epidermal growth factor receptors Glomerular Filtration Rate Humans Kidney diseases Kidneys Male Membrane separation Middle Aged Running - physiology Ultramarathon Urea Urea - blood Urea - urine Uric acid Uric Acid - blood Uric Acid - urine Urine |
| title | Glomerular Filtration Rate is Unchanged By Ultramarathon |
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