γ-Globin Gene Expression in Chemical Inducer of Dimerization (CID)-dependent Multipotential Cells Established from Human β-Globin Locus Yeast Artificial Chromosome (β-YAC) Transgenic Mice

Identification of trans-acting factors or drugs capable of reactivating γ-globin gene expression is complicated by the lack of suitable cell lines. Human K562 cells co-express ϵ- and γ-globin but not β-globin; transgenic mouse erythroleukemia 585 cells express predominantly human β-globin but also γ...

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Veröffentlicht in:	The Journal of biological chemistry 2005-11, Vol.280 (44), p.36642-36647
Hauptverfasser:	Blau, C. Anthony, Barbas, Carlos F., Bomhoff, Anna L., Neades, Renee, Yan, James, Navas, Patrick A., Peterson, Kenneth R.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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