Sequence-structure-function relationships of a tRNA (m super(7)G46) methyltransferase studied by homology modeling and site-directed mutagenesis

The Escherichia coli TrmB protein and its Saccharomyces cerevisiae ortholog Trm8p catalyze the S-adenosyl-L-methionine-dependent formation of 7- methylguanosine at position 46 (m super(7)G46) in tRNA. To learn more about the sequence-structure-function relationships of these enzymes we carried out a...

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Veröffentlicht in:	Proteins, structure, function, and bioinformatics structure, function, and bioinformatics, 2005-05, Vol.59 (3), p.482-488
Hauptverfasser:	Purta, El[zdot]bieta, Van Vliet, FranCoise, Tricot, Catherine, De Bie, Lara G, Feder, Marcin, Skowronek, Krzysztof, Droogmans, Louis, Bujnicki, Janusz M
Format:	Artikel
Sprache:	eng
Schlagworte:	Escherichia coli Saccharomyces cerevisiae
Online-Zugang:	Volltext
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