Selection of Cervical Keratinocytes Containing Integrated HPV16 Associates with Episome Loss and an Endogenous Antiviral Response

Integration of high-risk human papillomavirus (HRHPV) into the host genome is a key event in cervical neoplastic progression. Integration is associated with deregulated expression of the viral oncogenes E6 and E7 and acquisition of a selective growth advantage for cells containing integrants. Overex...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-03, Vol.103 (10), p.3822-3827
Hauptverfasser:	Pett, Mark R., Herdman, M. Trent, Palmer, Roger D., Yeo, Giles S. H., Shivji, Mahmud K., Stanley, Margaret A., Coleman, Nicholas
Format:	Artikel
Sprache:	eng
Schlagworte:	Antivirals Biological Sciences Cell growth Cell Line Cell lines Cells Cervix Uteri - cytology Cervix Uteri - immunology Cervix Uteri - virology Female Gene Expression Genes Genes, Viral Genomes Genomics Human papillomavirus Human papillomavirus 16 Human papillomavirus 16 - genetics Human papillomavirus 16 - immunology Human papillomavirus 16 - pathogenicity Humans Interferon Type I - genetics Keratinocytes Keratinocytes - immunology Keratinocytes - virology Medical research Models, Biological Oligonucleotide Array Sequence Analysis Oncogenes Plasmids Plasmids - genetics Uterine Cervical Neoplasms - etiology Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - virology Virus Integration - genetics Viruses
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