Crystal Structure of HEL4, a Soluble, Refoldable Human VH Single Domain with a Germ-line Scaffold

The antigen binding site of antibodies usually comprises associated heavy (VH) and light (VL) chain variable domains, but in camels and llamas, the binding site frequently comprises the heavy chain variable domain only (referred to as VHH). In contrast to reported human VH domains, VHH domains are w...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of molecular biology 2004-04, Vol.337 (4), p.893-903
Hauptverfasser:	Jespers, Laurent, Schon, Oliver, James, Leo C., Veprintsev, Dmitri, Winter, Greg
Format:	Artikel
Sprache:	eng
Schlagworte:	antibody crystal structure folding human VH single domain
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!