An assessment of the utility of the yeast GreenScreen assay in pharmaceutical screening

In this paper we describe an initial reproducibility study of 12 proprietary compounds followed by the assessment of 51 marketed pharmaceuticals and, lastly, a summary of the data so far from 2698 proprietary compounds from the Johnson & Johnson (J&J) compound library, in the yeast GreenScre...

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Veröffentlicht in:	Mutagenesis 2005-11, Vol.20 (6), p.449-454
Hauptverfasser:	Van Gompel, J., Woestenborghs, F., Beerens, D., Mackie, C., Cahill, P.A., Knight, A.W., Billinton, N., Tweats, D.J., Walmsley, R.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biological Assay - methods Carcinogenicity Tests - methods Carcinogens - pharmacology Cell Count DNA Damage - drug effects Drug Evaluation, Preclinical - methods Fundamental and applied biological sciences. Psychology Genes, Reporter - genetics Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Molecular and cellular biology Molecular genetics Mutagenesis. Repair Mutagenicity Tests - methods Reproducibility of Results Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism
Online-Zugang:	Volltext
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