Defects in cAMP-pathway may initiate carcinogenesis in dividing nerve cells: A review

The mechanisms of carcinogenesis in nervous tissues are not well understood. It is now established that adenosine 3,',5'-cyclic monophosphate (cAMP)-pathway plays a crucial role in initiating differentiation in transformed and embryonic cells of neuronal and glial origin. Therefore, we pro...

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Veröffentlicht in:	Apoptosis (London) 2003-12, Vol.8 (6), p.579-586
Hauptverfasser:	PRASAD, K. N, COLE, W. C, YAN, X.-D, NAHREINI, P, KUMAR, B, HANSON, A, PRASAD, J. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - metabolism Ageing, cell death Animals Biological and medical sciences Carcinogenesis Cell Division - physiology Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cyclic AMP - metabolism Defects Fundamental and applied biological sciences. Psychology Genes Genetic abnormalities Mice Molecular and cellular biology Nervous System Neoplasms - etiology Nervous System Neoplasms - metabolism Nervous tissues Neuroblastoma - metabolism Neurons - metabolism
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