Lipid Bilayer Simulations of CXCR4 with Inverse Agonists and Weak Partial Agonists

CXCR4 is a G protein-coupled receptor (GPCR) that has multiple critical functions in normal and pathologic physiology that include regulation of the metastatic behavior of mammary carcinoma, and utilization as a coreceptor for infection by T-tropic strains of human immunodeficiency virus-1. Molecula...

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Veröffentlicht in:	The Journal of biological chemistry 2003-11, Vol.278 (47), p.47136-47144
Hauptverfasser:	Trent, John O., Wang, Zi-xuan, Murray, James L., Shao, Wenhai, Tamamura, Hirokazu, Fujii, Nobutaka, Peiper, Stephen C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Computer Simulation Heterocyclic Compounds - metabolism Lipid Bilayers Membrane Proteins - chemistry Models, Molecular Oligopeptides - metabolism Protein Binding Protein Structure, Tertiary Receptors, CXCR4 - agonists Receptors, CXCR4 - chemistry Receptors, CXCR4 - genetics Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - chemistry
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