Induction of Phenotypes Resembling CuZn-Superoxide Dismutase Deletion in Wild-Type Yeast Cells: An in Vivo Assay for the Role of Superoxide in the Toxicity of Redox-Cycling Compounds

Yeast (Saccharomyces cerevisiae) lacking the enzyme CuZn-superoxide dismutase (sod1Δ) display a large number of dioxygen sensitive phenotypes, such as amino acid auxotrophies, sensitivity to elevated temperatures, and sensitivity to 100% dioxygen, which are attributed to superoxide stress. Such cell...

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Veröffentlicht in:	Chemical research in toxicology 2005-08, Vol.18 (8), p.1279-1286
Hauptverfasser:	Wallace, Matthew Alan, Bailey, Sasaneh, Fukuto, Jon M, Valentine, Joan Selverstone, Gralla, Edith Butler
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenylpyridinium - chemistry 2,2'-Dipyridyl - pharmacology Aconitate Hydratase - antagonists & inhibitors Aconitate Hydratase - metabolism Enzyme Inhibitors Gene Deletion Mutagens - toxicity Oxidation-Reduction Oxygen - chemistry Phenotype Quinones - pharmacology Saccharomyces cerevisiae Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - growth & development Superoxide Dismutase - genetics Superoxides - metabolism Vitamin K 3 - pharmacology
Online-Zugang:	Volltext
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