Ethanolic leaf extract of neem (Azadirachta indica) inhibits buccal pouch carcinogenesis in hamsters

We evaluated the chemopreventive effects of ethanolic neem leaf extract in the initiation and post‐initiation phases of 7,12‐dimethylbenz[a]anthracene (DMBA)‐induced hamster buccal pouch (HBP) carcinogenesis. The frequency of bone marrow micronuclei as well as the concentrations of lipid peroxides,...

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Veröffentlicht in:	Cell biochemistry and function 2005-07, Vol.23 (4), p.229-238
Hauptverfasser:	Subapriya, R., Bhuvaneswari, V., Ramesh, V., Nagini, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	9,10-Dimethyl-1,2-benzanthracene - toxicity Animals Antineoplastic Agents, Phytogenic - therapeutic use antioxidants Antioxidants - metabolism Azadirachta Azadirachta indica Carcinogens - toxicity Carcinoma, Squamous Cell - chemically induced Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - prevention & control chemoprevention Cricetinae Erythrocytes - drug effects Erythrocytes - metabolism Ethanol - pharmacology Glutathione - drug effects Glutathione Peroxidase - metabolism Glutathione Transferase - metabolism lipid peroxidation Lipid Peroxidation - drug effects Liver - drug effects Liver - metabolism Male Mesocricetus Micronuclei, Chromosome-Defective - drug effects Mouth Neoplasms - chemically induced Mouth Neoplasms - pathology Mouth Neoplasms - prevention & control neem leaf oral cancer oxidative stress Phytotherapy Plant Extracts - therapeutic use Plant Leaves
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