Synthesis and Antibacterial Activity of Quaternary Ammonium Salt-Type Antibacterial Agents with a Phosphate Group
Quaternary ammonium salts are frequently used as antibacterial agent that disrupts cell membrane through the binding of their ammonium cations to anionic sites in the outer layer tissue of bacteria. This article describes the synthesis of quaternary ammonium salt-type antibacterial agents with a pho...
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| Veröffentlicht in: | Journal of Oleo Science 2008, Vol.57(8), pp.445-452 |
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| container_end_page | 452 |
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| container_issue | 8 |
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| container_title | Journal of Oleo Science |
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| creator | Ohta, Yumi Kondo, Yukishige Kawada, Kazuo Teranaka, Toshio Yoshino, Norio |
| description | Quaternary ammonium salts are frequently used as antibacterial agent that disrupts cell membrane through the binding of their ammonium cations to anionic sites in the outer layer tissue of bacteria. This article describes the synthesis of quaternary ammonium salt-type antibacterial agents with a phosphate group that strongly binds to hydroxyapatite and bromide ion as counterion. Evaluation of the antibacterial activity of the synthesized compounds in terms of minimum inhibitory concentration (MIC test) showed that the compounds exhibit an excellent antibacterial activity on a variety of bacteria including Gram-positive and Gram-negative bacteria, yeast, and fungi. |
| doi_str_mv | 10.5650/jos.57.445 |
| format | Article |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Free Full-Text Journals in Chemistry |
| subjects | Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology antibacterial agent Antifungal Agents - chemical synthesis Antifungal Agents - pharmacology Binding Sites Bromides - chemistry Bromides - metabolism Cell Membrane - chemistry Cell Membrane - metabolism Durapatite - chemistry Durapatite - metabolism Fungi - drug effects Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects Microbial Sensitivity Tests minimum inhibitory concentration phosphate group Phosphates - chemistry Phosphates - metabolism Quaternary Ammonium Compounds - chemical synthesis Quaternary Ammonium Compounds - pharmacology quaternary ammonium salt Structure-Activity Relationship synthesis |
| title | Synthesis and Antibacterial Activity of Quaternary Ammonium Salt-Type Antibacterial Agents with a Phosphate Group |
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