Comparing the Efficacy of Tolterodine and Gabapentin Versus Placebo in Catheter Related Bladder Discomfort After Percutaneous Nephrolithotomy: A Randomized Clinical Trial
The purpose of this study was to compare the efficacy of tolterodine and gabapentin vs placebo in catheter related bladder discomfort (CRBD) following percutaneous nephrolithotomy (PCNL). This study was a double-blind parallel group randomized clinical trial. Patients who were candidates of PCNL wer...
Gespeichert in:
| Veröffentlicht in: | Journal of endourology 2018-02, Vol.32 (2), p.168-174 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 174 |
|---|---|
| container_issue | 2 |
| container_start_page | 168 |
| container_title | Journal of endourology |
| container_volume | 32 |
| creator | Maghsoudi, Robab Farhadi-Niaki, Saeed Etemadian, Masoud Kashi, Amir H Shadpour, Pejman Shirani, Asemaneh Samadinezhad-Khoshbaf-Sorkhabi, Rana Tabatabaei, Meghdad |
| description | The purpose of this study was to compare the efficacy of tolterodine and gabapentin vs placebo in catheter related bladder discomfort (CRBD) following percutaneous nephrolithotomy (PCNL).
This study was a double-blind parallel group randomized clinical trial. Patients who were candidates of PCNL were enrolled. Patients were randomized to treatment groups of tolterodine 2 mg orally (PO) (group T, n = 50), gabapentin 600 mg PO (group G, n = 50), and placebo (group P, n = 70) 1 hour before operation using balanced block randomization. The primary endpoint of interest was visual analog pain scale in 1, 3, 12, and 24 hours after the operation. Secondary endpoints included rescue analgesic use (opioid and nonopioid).
The frequency of severe CRBD in 1,12, and 24 hours after the operation was 4%, 4%, and 6% in group T vs 4%, 0%, and 2% in group G vs 47%, 14%, and 6% in the P group (p |
| doi_str_mv | 10.1089/end.2017.0563 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1981055788</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1981055788</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2733-d697a38dc53e6ac93cceb84d14603003aa3317a58a32973c1e34a3863338a5c33</originalsourceid><addsrcrecordid>eNo9kU9vEzEQxS0EomnLkSvykcsGeyf7x9zCUgpS1VZVQNxWE3uWGHnXi-0c0o_Ep6yjFE6WPT-_eTOPsbdSLKVo1QeazLIUslmKqoYXbCGrqimUED9fskWul0XTKHHGzmP8LYSEWsJrdlaqssk1tWB_Oz_OGOz0i6cd8athsBr1gfuBb7xLFLyxE3GcDL_GLc40JTvxHxTiPvJ7h5q2nueXDvP3jPMHcpjI8E8Ojcn3zzZqPw4-JL4ejsA9Bb1POJHPCrc074J3Nu188uPhI1_zh9zLj_Yxa3TOTtmO45tg0V2yVwO6SG-ezwv2_cvVpvta3Nxdf-vWN4UuG4DC1KpBaI2ugGrUCnT22K6MXNUChABEANlg1SKUqgEtCVaZrwGgxUoDXLD3J905-D97iqkf8wzk3MlzL1UrRd5y22a0OKE6-BgDDf0c7Ijh0EvRH-Ppczz9MZ7-GE_m3z1L77cjmf_0vzzgCV-Xjbw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1981055788</pqid></control><display><type>article</type><title>Comparing the Efficacy of Tolterodine and Gabapentin Versus Placebo in Catheter Related Bladder Discomfort After Percutaneous Nephrolithotomy: A Randomized Clinical Trial</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Maghsoudi, Robab ; Farhadi-Niaki, Saeed ; Etemadian, Masoud ; Kashi, Amir H ; Shadpour, Pejman ; Shirani, Asemaneh ; Samadinezhad-Khoshbaf-Sorkhabi, Rana ; Tabatabaei, Meghdad</creator><creatorcontrib>Maghsoudi, Robab ; Farhadi-Niaki, Saeed ; Etemadian, Masoud ; Kashi, Amir H ; Shadpour, Pejman ; Shirani, Asemaneh ; Samadinezhad-Khoshbaf-Sorkhabi, Rana ; Tabatabaei, Meghdad</creatorcontrib><description>The purpose of this study was to compare the efficacy of tolterodine and gabapentin vs placebo in catheter related bladder discomfort (CRBD) following percutaneous nephrolithotomy (PCNL).
This study was a double-blind parallel group randomized clinical trial. Patients who were candidates of PCNL were enrolled. Patients were randomized to treatment groups of tolterodine 2 mg orally (PO) (group T, n = 50), gabapentin 600 mg PO (group G, n = 50), and placebo (group P, n = 70) 1 hour before operation using balanced block randomization. The primary endpoint of interest was visual analog pain scale in 1, 3, 12, and 24 hours after the operation. Secondary endpoints included rescue analgesic use (opioid and nonopioid).
The frequency of severe CRBD in 1,12, and 24 hours after the operation was 4%, 4%, and 6% in group T vs 4%, 0%, and 2% in group G vs 47%, 14%, and 6% in the P group (p < 0.001). The number of paracetamol injections for CRBD in the T and G groups was significantly lower than the placebo group (1.8 ± 0.8 vs 1.8 ± 0.7 vs 3.6 ± 0.7, p < 0.001). Likewise the number of pethidine injections in the T and G groups was significantly lower than the placebo group (0.42 ± 0.54 vs 0.68 ± 0.62 vs 2.4 ± 0.64, p < 0.001). In patients with history of Double-J insertion, the severity of CRBD was lower in all treatment groups.
Preoperative administration of oral tolterodine or gabapentin reduces postoperative CRBD and the need for rescue analgesics as much as 24 hours after surgery. Patients with history of Double-J insertion experience less CRBD.</description><identifier>ISSN: 0892-7790</identifier><identifier>EISSN: 1557-900X</identifier><identifier>DOI: 10.1089/end.2017.0563</identifier><identifier>PMID: 29278929</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Analgesics - therapeutic use ; Double-Blind Method ; Female ; Gabapentin - therapeutic use ; Humans ; Kidney Calculi - surgery ; Male ; Middle Aged ; Nephrolithotomy, Percutaneous ; Pain Measurement ; Pain, Postoperative - drug therapy ; Pain, Postoperative - etiology ; Prospective Studies ; Tolterodine Tartrate - therapeutic use ; Urinary Catheterization - adverse effects ; Urinary Catheters - adverse effects ; Urological Agents - therapeutic use</subject><ispartof>Journal of endourology, 2018-02, Vol.32 (2), p.168-174</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2733-d697a38dc53e6ac93cceb84d14603003aa3317a58a32973c1e34a3863338a5c33</citedby><cites>FETCH-LOGICAL-c2733-d697a38dc53e6ac93cceb84d14603003aa3317a58a32973c1e34a3863338a5c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29278929$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maghsoudi, Robab</creatorcontrib><creatorcontrib>Farhadi-Niaki, Saeed</creatorcontrib><creatorcontrib>Etemadian, Masoud</creatorcontrib><creatorcontrib>Kashi, Amir H</creatorcontrib><creatorcontrib>Shadpour, Pejman</creatorcontrib><creatorcontrib>Shirani, Asemaneh</creatorcontrib><creatorcontrib>Samadinezhad-Khoshbaf-Sorkhabi, Rana</creatorcontrib><creatorcontrib>Tabatabaei, Meghdad</creatorcontrib><title>Comparing the Efficacy of Tolterodine and Gabapentin Versus Placebo in Catheter Related Bladder Discomfort After Percutaneous Nephrolithotomy: A Randomized Clinical Trial</title><title>Journal of endourology</title><addtitle>J Endourol</addtitle><description>The purpose of this study was to compare the efficacy of tolterodine and gabapentin vs placebo in catheter related bladder discomfort (CRBD) following percutaneous nephrolithotomy (PCNL).
This study was a double-blind parallel group randomized clinical trial. Patients who were candidates of PCNL were enrolled. Patients were randomized to treatment groups of tolterodine 2 mg orally (PO) (group T, n = 50), gabapentin 600 mg PO (group G, n = 50), and placebo (group P, n = 70) 1 hour before operation using balanced block randomization. The primary endpoint of interest was visual analog pain scale in 1, 3, 12, and 24 hours after the operation. Secondary endpoints included rescue analgesic use (opioid and nonopioid).
The frequency of severe CRBD in 1,12, and 24 hours after the operation was 4%, 4%, and 6% in group T vs 4%, 0%, and 2% in group G vs 47%, 14%, and 6% in the P group (p < 0.001). The number of paracetamol injections for CRBD in the T and G groups was significantly lower than the placebo group (1.8 ± 0.8 vs 1.8 ± 0.7 vs 3.6 ± 0.7, p < 0.001). Likewise the number of pethidine injections in the T and G groups was significantly lower than the placebo group (0.42 ± 0.54 vs 0.68 ± 0.62 vs 2.4 ± 0.64, p < 0.001). In patients with history of Double-J insertion, the severity of CRBD was lower in all treatment groups.
Preoperative administration of oral tolterodine or gabapentin reduces postoperative CRBD and the need for rescue analgesics as much as 24 hours after surgery. Patients with history of Double-J insertion experience less CRBD.</description><subject>Adult</subject><subject>Analgesics - therapeutic use</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Gabapentin - therapeutic use</subject><subject>Humans</subject><subject>Kidney Calculi - surgery</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nephrolithotomy, Percutaneous</subject><subject>Pain Measurement</subject><subject>Pain, Postoperative - drug therapy</subject><subject>Pain, Postoperative - etiology</subject><subject>Prospective Studies</subject><subject>Tolterodine Tartrate - therapeutic use</subject><subject>Urinary Catheterization - adverse effects</subject><subject>Urinary Catheters - adverse effects</subject><subject>Urological Agents - therapeutic use</subject><issn>0892-7790</issn><issn>1557-900X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kU9vEzEQxS0EomnLkSvykcsGeyf7x9zCUgpS1VZVQNxWE3uWGHnXi-0c0o_Ep6yjFE6WPT-_eTOPsbdSLKVo1QeazLIUslmKqoYXbCGrqimUED9fskWul0XTKHHGzmP8LYSEWsJrdlaqssk1tWB_Oz_OGOz0i6cd8athsBr1gfuBb7xLFLyxE3GcDL_GLc40JTvxHxTiPvJ7h5q2nueXDvP3jPMHcpjI8E8Ojcn3zzZqPw4-JL4ejsA9Bb1POJHPCrc074J3Nu188uPhI1_zh9zLj_Yxa3TOTtmO45tg0V2yVwO6SG-ezwv2_cvVpvta3Nxdf-vWN4UuG4DC1KpBaI2ugGrUCnT22K6MXNUChABEANlg1SKUqgEtCVaZrwGgxUoDXLD3J905-D97iqkf8wzk3MlzL1UrRd5y22a0OKE6-BgDDf0c7Ijh0EvRH-Ppczz9MZ7-GE_m3z1L77cjmf_0vzzgCV-Xjbw</recordid><startdate>20180201</startdate><enddate>20180201</enddate><creator>Maghsoudi, Robab</creator><creator>Farhadi-Niaki, Saeed</creator><creator>Etemadian, Masoud</creator><creator>Kashi, Amir H</creator><creator>Shadpour, Pejman</creator><creator>Shirani, Asemaneh</creator><creator>Samadinezhad-Khoshbaf-Sorkhabi, Rana</creator><creator>Tabatabaei, Meghdad</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180201</creationdate><title>Comparing the Efficacy of Tolterodine and Gabapentin Versus Placebo in Catheter Related Bladder Discomfort After Percutaneous Nephrolithotomy: A Randomized Clinical Trial</title><author>Maghsoudi, Robab ; Farhadi-Niaki, Saeed ; Etemadian, Masoud ; Kashi, Amir H ; Shadpour, Pejman ; Shirani, Asemaneh ; Samadinezhad-Khoshbaf-Sorkhabi, Rana ; Tabatabaei, Meghdad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2733-d697a38dc53e6ac93cceb84d14603003aa3317a58a32973c1e34a3863338a5c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Analgesics - therapeutic use</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Gabapentin - therapeutic use</topic><topic>Humans</topic><topic>Kidney Calculi - surgery</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nephrolithotomy, Percutaneous</topic><topic>Pain Measurement</topic><topic>Pain, Postoperative - drug therapy</topic><topic>Pain, Postoperative - etiology</topic><topic>Prospective Studies</topic><topic>Tolterodine Tartrate - therapeutic use</topic><topic>Urinary Catheterization - adverse effects</topic><topic>Urinary Catheters - adverse effects</topic><topic>Urological Agents - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maghsoudi, Robab</creatorcontrib><creatorcontrib>Farhadi-Niaki, Saeed</creatorcontrib><creatorcontrib>Etemadian, Masoud</creatorcontrib><creatorcontrib>Kashi, Amir H</creatorcontrib><creatorcontrib>Shadpour, Pejman</creatorcontrib><creatorcontrib>Shirani, Asemaneh</creatorcontrib><creatorcontrib>Samadinezhad-Khoshbaf-Sorkhabi, Rana</creatorcontrib><creatorcontrib>Tabatabaei, Meghdad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endourology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maghsoudi, Robab</au><au>Farhadi-Niaki, Saeed</au><au>Etemadian, Masoud</au><au>Kashi, Amir H</au><au>Shadpour, Pejman</au><au>Shirani, Asemaneh</au><au>Samadinezhad-Khoshbaf-Sorkhabi, Rana</au><au>Tabatabaei, Meghdad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparing the Efficacy of Tolterodine and Gabapentin Versus Placebo in Catheter Related Bladder Discomfort After Percutaneous Nephrolithotomy: A Randomized Clinical Trial</atitle><jtitle>Journal of endourology</jtitle><addtitle>J Endourol</addtitle><date>2018-02-01</date><risdate>2018</risdate><volume>32</volume><issue>2</issue><spage>168</spage><epage>174</epage><pages>168-174</pages><issn>0892-7790</issn><eissn>1557-900X</eissn><abstract>The purpose of this study was to compare the efficacy of tolterodine and gabapentin vs placebo in catheter related bladder discomfort (CRBD) following percutaneous nephrolithotomy (PCNL).
This study was a double-blind parallel group randomized clinical trial. Patients who were candidates of PCNL were enrolled. Patients were randomized to treatment groups of tolterodine 2 mg orally (PO) (group T, n = 50), gabapentin 600 mg PO (group G, n = 50), and placebo (group P, n = 70) 1 hour before operation using balanced block randomization. The primary endpoint of interest was visual analog pain scale in 1, 3, 12, and 24 hours after the operation. Secondary endpoints included rescue analgesic use (opioid and nonopioid).
The frequency of severe CRBD in 1,12, and 24 hours after the operation was 4%, 4%, and 6% in group T vs 4%, 0%, and 2% in group G vs 47%, 14%, and 6% in the P group (p < 0.001). The number of paracetamol injections for CRBD in the T and G groups was significantly lower than the placebo group (1.8 ± 0.8 vs 1.8 ± 0.7 vs 3.6 ± 0.7, p < 0.001). Likewise the number of pethidine injections in the T and G groups was significantly lower than the placebo group (0.42 ± 0.54 vs 0.68 ± 0.62 vs 2.4 ± 0.64, p < 0.001). In patients with history of Double-J insertion, the severity of CRBD was lower in all treatment groups.
Preoperative administration of oral tolterodine or gabapentin reduces postoperative CRBD and the need for rescue analgesics as much as 24 hours after surgery. Patients with history of Double-J insertion experience less CRBD.</abstract><cop>United States</cop><pmid>29278929</pmid><doi>10.1089/end.2017.0563</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0892-7790 |
| ispartof | Journal of endourology, 2018-02, Vol.32 (2), p.168-174 |
| issn | 0892-7790 1557-900X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1981055788 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Analgesics - therapeutic use Double-Blind Method Female Gabapentin - therapeutic use Humans Kidney Calculi - surgery Male Middle Aged Nephrolithotomy, Percutaneous Pain Measurement Pain, Postoperative - drug therapy Pain, Postoperative - etiology Prospective Studies Tolterodine Tartrate - therapeutic use Urinary Catheterization - adverse effects Urinary Catheters - adverse effects Urological Agents - therapeutic use |
| title | Comparing the Efficacy of Tolterodine and Gabapentin Versus Placebo in Catheter Related Bladder Discomfort After Percutaneous Nephrolithotomy: A Randomized Clinical Trial |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T07%3A34%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparing%20the%20Efficacy%20of%20Tolterodine%20and%20Gabapentin%20Versus%20Placebo%20in%20Catheter%20Related%20Bladder%20Discomfort%20After%20Percutaneous%20Nephrolithotomy:%20A%20Randomized%20Clinical%20Trial&rft.jtitle=Journal%20of%20endourology&rft.au=Maghsoudi,%20Robab&rft.date=2018-02-01&rft.volume=32&rft.issue=2&rft.spage=168&rft.epage=174&rft.pages=168-174&rft.issn=0892-7790&rft.eissn=1557-900X&rft_id=info:doi/10.1089/end.2017.0563&rft_dat=%3Cproquest_cross%3E1981055788%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1981055788&rft_id=info:pmid/29278929&rfr_iscdi=true |