Human Parainfluenza Virus Type 3 Infections in Patients with Hematopoietic Stem Cell Transplants: the Mode of Nosocomial Infections and Prognosis
There have been a few prospective and comprehensive surveillance studies on the respiratory viral infections (RVIs) among patients undergoing hematopoietic stem cell transplantation (HSCT). A 2-year prospective cohort surveillance study of symptomatic and asymptomatic RVIs was performed in hospitali...
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Veröffentlicht in: | Japanese Journal of Infectious Diseases 2018, Vol.71(2), pp.109-115 |
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creator | Kakiuchi, Satsuki Tsuji, Masanori Nishimura, Hidekazu Wang, Lixing Takayama-Ito, Mutsuyo Kinoshita, Hitomi Lim, Chang-Kweng Taniguchi, Shuichi Oka, Akira Mizuguchi, Masashi Saijo, Masayuki |
description | There have been a few prospective and comprehensive surveillance studies on the respiratory viral infections (RVIs) among patients undergoing hematopoietic stem cell transplantation (HSCT). A 2-year prospective cohort surveillance study of symptomatic and asymptomatic RVIs was performed in hospitalized HSCT patients. Oropharyngeal (OP) swab samples were serially collected each week from 1 week before and up to 100 days after HSCT and were tested for virus isolation with cell culture-based viral isolation (CC-based VI) and a multiplex PCR (MPCR). A total of 2,747 OP swab samples were collected from 250 HSCT patients (268 HSCT procedures). Among these patients, 79 had RVIs (CC-based VI, n = 63; MPCR, n = 17). The parainfluenza virus type 3 (PIV3) accounted for 71% (57/80) of the cases of RVIs. Some PIV3 infections were asymptomatic and involved a longer virus-shedding period. The PIV3 was often cultured from samples taken before the onset of a respiratory disease. The PIV3 infections were attributed to the transmission of nosocomial infections. PIV3 infections before engraftment will more likely result in the development of lower respiratory tract infections and worse outcomes. A real-time monitoring of respiratory viral infections in the HSCT ward among patients with or without respiratory symptoms is required for the prevention of nosocomial RVIs, especially of PIV3 infections. |
doi_str_mv | 10.7883/yoken.JJID.2017.424 |
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A 2-year prospective cohort surveillance study of symptomatic and asymptomatic RVIs was performed in hospitalized HSCT patients. Oropharyngeal (OP) swab samples were serially collected each week from 1 week before and up to 100 days after HSCT and were tested for virus isolation with cell culture-based viral isolation (CC-based VI) and a multiplex PCR (MPCR). A total of 2,747 OP swab samples were collected from 250 HSCT patients (268 HSCT procedures). Among these patients, 79 had RVIs (CC-based VI, n = 63; MPCR, n = 17). The parainfluenza virus type 3 (PIV3) accounted for 71% (57/80) of the cases of RVIs. Some PIV3 infections were asymptomatic and involved a longer virus-shedding period. The PIV3 was often cultured from samples taken before the onset of a respiratory disease. The PIV3 infections were attributed to the transmission of nosocomial infections. PIV3 infections before engraftment will more likely result in the development of lower respiratory tract infections and worse outcomes. A real-time monitoring of respiratory viral infections in the HSCT ward among patients with or without respiratory symptoms is required for the prevention of nosocomial RVIs, especially of PIV3 infections.</description><identifier>ISSN: 1344-6304</identifier><identifier>EISSN: 1884-2836</identifier><identifier>DOI: 10.7883/yoken.JJID.2017.424</identifier><identifier>PMID: 29279454</identifier><language>eng</language><publisher>Japan: National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee</publisher><subject>Cell culture ; hematopoietic stem cell transplantation ; Hematopoietic stem cells ; human parainfluenza virus type 3 ; immunocompromised patients ; Nosocomial infection ; Nosocomial infections ; Parainfluenza ; Patients ; Respiratory tract ; Respiratory tract diseases ; respiratory virus infection ; Stem cell transplantation ; Stem cells ; Surveillance ; Transplantation ; Transplants ; Transplants & implants ; Viral infections ; Viruses</subject><ispartof>Japanese Journal of Infectious Diseases, 2018, Vol.71(2), pp.109-115</ispartof><rights>Authors</rights><rights>Copyright Japan Science and Technology Agency 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c534t-56d3bab963cc6040730fdcb60a5e6600f4ba058385ecf8d2ff7989507237208e3</citedby><cites>FETCH-LOGICAL-c534t-56d3bab963cc6040730fdcb60a5e6600f4ba058385ecf8d2ff7989507237208e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29279454$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kakiuchi, Satsuki</creatorcontrib><creatorcontrib>Tsuji, Masanori</creatorcontrib><creatorcontrib>Nishimura, Hidekazu</creatorcontrib><creatorcontrib>Wang, Lixing</creatorcontrib><creatorcontrib>Takayama-Ito, Mutsuyo</creatorcontrib><creatorcontrib>Kinoshita, Hitomi</creatorcontrib><creatorcontrib>Lim, Chang-Kweng</creatorcontrib><creatorcontrib>Taniguchi, Shuichi</creatorcontrib><creatorcontrib>Oka, Akira</creatorcontrib><creatorcontrib>Mizuguchi, Masashi</creatorcontrib><creatorcontrib>Saijo, Masayuki</creatorcontrib><title>Human Parainfluenza Virus Type 3 Infections in Patients with Hematopoietic Stem Cell Transplants: the Mode of Nosocomial Infections and Prognosis</title><title>Japanese Journal of Infectious Diseases</title><addtitle>Jpn J Infect Dis</addtitle><description>There have been a few prospective and comprehensive surveillance studies on the respiratory viral infections (RVIs) among patients undergoing hematopoietic stem cell transplantation (HSCT). A 2-year prospective cohort surveillance study of symptomatic and asymptomatic RVIs was performed in hospitalized HSCT patients. Oropharyngeal (OP) swab samples were serially collected each week from 1 week before and up to 100 days after HSCT and were tested for virus isolation with cell culture-based viral isolation (CC-based VI) and a multiplex PCR (MPCR). A total of 2,747 OP swab samples were collected from 250 HSCT patients (268 HSCT procedures). Among these patients, 79 had RVIs (CC-based VI, n = 63; MPCR, n = 17). The parainfluenza virus type 3 (PIV3) accounted for 71% (57/80) of the cases of RVIs. Some PIV3 infections were asymptomatic and involved a longer virus-shedding period. The PIV3 was often cultured from samples taken before the onset of a respiratory disease. The PIV3 infections were attributed to the transmission of nosocomial infections. PIV3 infections before engraftment will more likely result in the development of lower respiratory tract infections and worse outcomes. A real-time monitoring of respiratory viral infections in the HSCT ward among patients with or without respiratory symptoms is required for the prevention of nosocomial RVIs, especially of PIV3 infections.</description><subject>Cell culture</subject><subject>hematopoietic stem cell transplantation</subject><subject>Hematopoietic stem cells</subject><subject>human parainfluenza virus type 3</subject><subject>immunocompromised patients</subject><subject>Nosocomial infection</subject><subject>Nosocomial infections</subject><subject>Parainfluenza</subject><subject>Patients</subject><subject>Respiratory tract</subject><subject>Respiratory tract diseases</subject><subject>respiratory virus infection</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Surveillance</subject><subject>Transplantation</subject><subject>Transplants</subject><subject>Transplants & implants</subject><subject>Viral infections</subject><subject>Viruses</subject><issn>1344-6304</issn><issn>1884-2836</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpdkcuO0zAUQCMEYh7wBUjIEhs2KX4mDjtUGNrRACNR2FqOczN1SeyM7QiVv-CPSWipgI3txblHVz5Z9ozgRSkle7X338Atrq_XbxcUk3LBKX-QnRMpeU4lKx5Ob8Z5XjDMz7KLGHcYUyEIfpyd0YqWFRf8PPu5Gnvt0K0O2rq2G8H90OirDWNEm_0AiKG1a8Ek611EdgaTBZci-m7TFq2g18kP3kKyBn1O0KMldB3aBO3i0OkJfI3SFtAH3wDyLfrooze-t7r726tdg26Dv3M-2vgke9TqLsLT432Zfbl6t1mu8ptP79fLNze5EYynXBQNq3VdFcyYAnNcMtw2pi6wFlAUGLe81lhIJgWYVja0bctKVgKXlJUUS2CX2cuDdwj-foSYVG-jmbbXDvwYFakkwUIUVTWhL_5Dd34MbtpOUUwpIZxgPlHsQJngYwzQqiHYXoe9IljNxdTvYmoupuZiaio2TT0_use6h-Y08yfRBKwPwC4mfQcnQIfpzzs4Skui6Hz8Iz8xZquDAsd-ARl8rp0</recordid><startdate>2018</startdate><enddate>2018</enddate><creator>Kakiuchi, Satsuki</creator><creator>Tsuji, Masanori</creator><creator>Nishimura, Hidekazu</creator><creator>Wang, Lixing</creator><creator>Takayama-Ito, Mutsuyo</creator><creator>Kinoshita, Hitomi</creator><creator>Lim, Chang-Kweng</creator><creator>Taniguchi, Shuichi</creator><creator>Oka, Akira</creator><creator>Mizuguchi, Masashi</creator><creator>Saijo, Masayuki</creator><general>National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee</general><general>Japan Science and Technology Agency</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>2018</creationdate><title>Human Parainfluenza Virus Type 3 Infections in Patients with Hematopoietic Stem Cell Transplants: the Mode of Nosocomial Infections and Prognosis</title><author>Kakiuchi, Satsuki ; Tsuji, Masanori ; Nishimura, Hidekazu ; Wang, Lixing ; Takayama-Ito, Mutsuyo ; Kinoshita, Hitomi ; Lim, Chang-Kweng ; Taniguchi, Shuichi ; Oka, Akira ; Mizuguchi, Masashi ; Saijo, Masayuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-56d3bab963cc6040730fdcb60a5e6600f4ba058385ecf8d2ff7989507237208e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Cell culture</topic><topic>hematopoietic stem cell transplantation</topic><topic>Hematopoietic stem cells</topic><topic>human parainfluenza virus type 3</topic><topic>immunocompromised patients</topic><topic>Nosocomial infection</topic><topic>Nosocomial infections</topic><topic>Parainfluenza</topic><topic>Patients</topic><topic>Respiratory tract</topic><topic>Respiratory tract diseases</topic><topic>respiratory virus infection</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Surveillance</topic><topic>Transplantation</topic><topic>Transplants</topic><topic>Transplants & implants</topic><topic>Viral infections</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kakiuchi, Satsuki</creatorcontrib><creatorcontrib>Tsuji, Masanori</creatorcontrib><creatorcontrib>Nishimura, Hidekazu</creatorcontrib><creatorcontrib>Wang, Lixing</creatorcontrib><creatorcontrib>Takayama-Ito, Mutsuyo</creatorcontrib><creatorcontrib>Kinoshita, Hitomi</creatorcontrib><creatorcontrib>Lim, Chang-Kweng</creatorcontrib><creatorcontrib>Taniguchi, Shuichi</creatorcontrib><creatorcontrib>Oka, Akira</creatorcontrib><creatorcontrib>Mizuguchi, Masashi</creatorcontrib><creatorcontrib>Saijo, Masayuki</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese Journal of Infectious Diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kakiuchi, Satsuki</au><au>Tsuji, Masanori</au><au>Nishimura, Hidekazu</au><au>Wang, Lixing</au><au>Takayama-Ito, Mutsuyo</au><au>Kinoshita, Hitomi</au><au>Lim, Chang-Kweng</au><au>Taniguchi, Shuichi</au><au>Oka, Akira</au><au>Mizuguchi, Masashi</au><au>Saijo, Masayuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human Parainfluenza Virus Type 3 Infections in Patients with Hematopoietic Stem Cell Transplants: the Mode of Nosocomial Infections and Prognosis</atitle><jtitle>Japanese Journal of Infectious Diseases</jtitle><addtitle>Jpn J Infect Dis</addtitle><date>2018</date><risdate>2018</risdate><volume>71</volume><issue>2</issue><spage>109</spage><epage>115</epage><pages>109-115</pages><issn>1344-6304</issn><eissn>1884-2836</eissn><abstract>There have been a few prospective and comprehensive surveillance studies on the respiratory viral infections (RVIs) among patients undergoing hematopoietic stem cell transplantation (HSCT). A 2-year prospective cohort surveillance study of symptomatic and asymptomatic RVIs was performed in hospitalized HSCT patients. Oropharyngeal (OP) swab samples were serially collected each week from 1 week before and up to 100 days after HSCT and were tested for virus isolation with cell culture-based viral isolation (CC-based VI) and a multiplex PCR (MPCR). A total of 2,747 OP swab samples were collected from 250 HSCT patients (268 HSCT procedures). Among these patients, 79 had RVIs (CC-based VI, n = 63; MPCR, n = 17). The parainfluenza virus type 3 (PIV3) accounted for 71% (57/80) of the cases of RVIs. Some PIV3 infections were asymptomatic and involved a longer virus-shedding period. The PIV3 was often cultured from samples taken before the onset of a respiratory disease. The PIV3 infections were attributed to the transmission of nosocomial infections. PIV3 infections before engraftment will more likely result in the development of lower respiratory tract infections and worse outcomes. A real-time monitoring of respiratory viral infections in the HSCT ward among patients with or without respiratory symptoms is required for the prevention of nosocomial RVIs, especially of PIV3 infections.</abstract><cop>Japan</cop><pub>National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee</pub><pmid>29279454</pmid><doi>10.7883/yoken.JJID.2017.424</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Cell culture hematopoietic stem cell transplantation Hematopoietic stem cells human parainfluenza virus type 3 immunocompromised patients Nosocomial infection Nosocomial infections Parainfluenza Patients Respiratory tract Respiratory tract diseases respiratory virus infection Stem cell transplantation Stem cells Surveillance Transplantation Transplants Transplants & implants Viral infections Viruses |
title | Human Parainfluenza Virus Type 3 Infections in Patients with Hematopoietic Stem Cell Transplants: the Mode of Nosocomial Infections and Prognosis |
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