Retroperitoneal ectopic brain: Case report and literature review
Heterotopic neural tissue (HNT) has been identified in many sites. In our literature review, we have found only two cases of HNT located in the retroperitoneum. As far as we know, cytological features of HNT have not been described. We here report a case of retroperitoneal HNT diagnosed by fine‐need...
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| Veröffentlicht in: | Diagnostic cytopathology 2018-06, Vol.46 (6), p.528-531 |
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| creator | Díaz del Arco, Cristina Ortega Medina, Luis Subhi‐Issa Ahmad, Issa |
| description | Heterotopic neural tissue (HNT) has been identified in many sites. In our literature review, we have found only two cases of HNT located in the retroperitoneum. As far as we know, cytological features of HNT have not been described. We here report a case of retroperitoneal HNT diagnosed by fine‐needle aspiration (FNA) cytology and subsequent resection. Our patient was a male infant born at 26 weeks’ gestation. A retroperitoneal solid‐cystic lesion measuring 3.8 cm was identified by abdominal ultrasound. FNA was performed and cytology showed highly cellular smears with single cells and masses of fibrillary material. Cells were small with rounded irregular nuclei and variable cytoplasm. Multinucleated cells, cells with neuronal morphology, calcifications, and hemosiderophages could also be seen. The lesion was excised and histology showed fibrillary areas, glial cells, neurons, and ependymal cells. Synaptophysin, GFAP, and EMA were expressed in distinct areas and cell types. No recurrences were observed. |
| doi_str_mv | 10.1002/dc.23882 |
| format | Article |
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In our literature review, we have found only two cases of HNT located in the retroperitoneum. As far as we know, cytological features of HNT have not been described. We here report a case of retroperitoneal HNT diagnosed by fine‐needle aspiration (FNA) cytology and subsequent resection. Our patient was a male infant born at 26 weeks’ gestation. A retroperitoneal solid‐cystic lesion measuring 3.8 cm was identified by abdominal ultrasound. FNA was performed and cytology showed highly cellular smears with single cells and masses of fibrillary material. Cells were small with rounded irregular nuclei and variable cytoplasm. Multinucleated cells, cells with neuronal morphology, calcifications, and hemosiderophages could also be seen. The lesion was excised and histology showed fibrillary areas, glial cells, neurons, and ependymal cells. Synaptophysin, GFAP, and EMA were expressed in distinct areas and cell types. No recurrences were observed.</description><identifier>ISSN: 8755-1039</identifier><identifier>EISSN: 1097-0339</identifier><identifier>DOI: 10.1002/dc.23882</identifier><identifier>PMID: 29280334</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Biomarkers - metabolism ; Biopsy, Fine-Needle ; Brain ; Case reports ; Cellular biology ; Choristoma - diagnostic imaging ; Choristoma - pathology ; Cytology ; Cytoplasm ; ectopic brain ; ectopic neural tissue ; Ependymal cells ; fine‐needle aspiration cytology ; Gestation ; Glial cells ; Glial fibrillary acidic protein ; glial heterotopia ; Histology ; Humans ; Infant, Extremely Premature ; Infant, Newborn ; Literature reviews ; Male ; Neuronal-glial interactions ; Nuclei (cytology) ; Peritoneal Diseases - diagnostic imaging ; Peritoneal Diseases - pathology ; Retroperitoneal Space - diagnostic imaging ; Retroperitoneal Space - pathology ; Retroperitoneum ; Synaptophysin</subject><ispartof>Diagnostic cytopathology, 2018-06, Vol.46 (6), p.528-531</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3492-c22f9fb818c638307ed1ac40c9713b822e6aa1ca1c15f2c47bade37824ead7a83</citedby><cites>FETCH-LOGICAL-c3492-c22f9fb818c638307ed1ac40c9713b822e6aa1ca1c15f2c47bade37824ead7a83</cites><orcidid>0000-0002-6100-4967</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fdc.23882$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fdc.23882$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29280334$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Díaz del Arco, Cristina</creatorcontrib><creatorcontrib>Ortega Medina, Luis</creatorcontrib><creatorcontrib>Subhi‐Issa Ahmad, Issa</creatorcontrib><title>Retroperitoneal ectopic brain: Case report and literature review</title><title>Diagnostic cytopathology</title><addtitle>Diagn Cytopathol</addtitle><description>Heterotopic neural tissue (HNT) has been identified in many sites. In our literature review, we have found only two cases of HNT located in the retroperitoneum. As far as we know, cytological features of HNT have not been described. We here report a case of retroperitoneal HNT diagnosed by fine‐needle aspiration (FNA) cytology and subsequent resection. Our patient was a male infant born at 26 weeks’ gestation. A retroperitoneal solid‐cystic lesion measuring 3.8 cm was identified by abdominal ultrasound. FNA was performed and cytology showed highly cellular smears with single cells and masses of fibrillary material. Cells were small with rounded irregular nuclei and variable cytoplasm. Multinucleated cells, cells with neuronal morphology, calcifications, and hemosiderophages could also be seen. The lesion was excised and histology showed fibrillary areas, glial cells, neurons, and ependymal cells. Synaptophysin, GFAP, and EMA were expressed in distinct areas and cell types. No recurrences were observed.</description><subject>Biomarkers - metabolism</subject><subject>Biopsy, Fine-Needle</subject><subject>Brain</subject><subject>Case reports</subject><subject>Cellular biology</subject><subject>Choristoma - diagnostic imaging</subject><subject>Choristoma - pathology</subject><subject>Cytology</subject><subject>Cytoplasm</subject><subject>ectopic brain</subject><subject>ectopic neural tissue</subject><subject>Ependymal cells</subject><subject>fine‐needle aspiration cytology</subject><subject>Gestation</subject><subject>Glial cells</subject><subject>Glial fibrillary acidic protein</subject><subject>glial heterotopia</subject><subject>Histology</subject><subject>Humans</subject><subject>Infant, Extremely Premature</subject><subject>Infant, Newborn</subject><subject>Literature reviews</subject><subject>Male</subject><subject>Neuronal-glial interactions</subject><subject>Nuclei (cytology)</subject><subject>Peritoneal Diseases - diagnostic imaging</subject><subject>Peritoneal Diseases - pathology</subject><subject>Retroperitoneal Space - diagnostic imaging</subject><subject>Retroperitoneal Space - pathology</subject><subject>Retroperitoneum</subject><subject>Synaptophysin</subject><issn>8755-1039</issn><issn>1097-0339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kF1LwzAUhoMobk7BXyAFb7zpTE7aJfFKqZ8wEESvQ5qeQkbX1qR17N_buSkiCAdeODw85_AScsrolFEKl4WdApcS9siYUSViyrnaJ2Mp0jRmlKsROQphQSlVwGaHZAQK5MAkY3L9gp1vWvSua2o0VYS2a1pno9wbV19FmQkYeWwb30WmLqLKdehN1_vN9sPh6pgclKYKeLLLCXm7v3vNHuP588NTdjOPLU8UxBagVGUumbQzLjkVWDBjE2qVYDyXADgzhtlhWFqCTURuCuRCQoKmEEbyCbnYelvfvPcYOr10wWJVmRqbPmimJKNpAlwN6PkfdNH0vh6-00C5GI5L-CW0vgnBY6lb75bGrzWjetOqLqz-anVAz3bCPl9i8QN-1zgA8RZYuQrX_4r0bbYVfgJJq363</recordid><startdate>201806</startdate><enddate>201806</enddate><creator>Díaz del Arco, Cristina</creator><creator>Ortega Medina, Luis</creator><creator>Subhi‐Issa Ahmad, Issa</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6100-4967</orcidid></search><sort><creationdate>201806</creationdate><title>Retroperitoneal ectopic brain: Case report and literature review</title><author>Díaz del Arco, Cristina ; Ortega Medina, Luis ; Subhi‐Issa Ahmad, Issa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3492-c22f9fb818c638307ed1ac40c9713b822e6aa1ca1c15f2c47bade37824ead7a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Biomarkers - metabolism</topic><topic>Biopsy, Fine-Needle</topic><topic>Brain</topic><topic>Case reports</topic><topic>Cellular biology</topic><topic>Choristoma - diagnostic imaging</topic><topic>Choristoma - pathology</topic><topic>Cytology</topic><topic>Cytoplasm</topic><topic>ectopic brain</topic><topic>ectopic neural tissue</topic><topic>Ependymal cells</topic><topic>fine‐needle aspiration cytology</topic><topic>Gestation</topic><topic>Glial cells</topic><topic>Glial fibrillary acidic protein</topic><topic>glial heterotopia</topic><topic>Histology</topic><topic>Humans</topic><topic>Infant, Extremely Premature</topic><topic>Infant, Newborn</topic><topic>Literature reviews</topic><topic>Male</topic><topic>Neuronal-glial interactions</topic><topic>Nuclei (cytology)</topic><topic>Peritoneal Diseases - diagnostic imaging</topic><topic>Peritoneal Diseases - pathology</topic><topic>Retroperitoneal Space - diagnostic imaging</topic><topic>Retroperitoneal Space - pathology</topic><topic>Retroperitoneum</topic><topic>Synaptophysin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Díaz del Arco, Cristina</creatorcontrib><creatorcontrib>Ortega Medina, Luis</creatorcontrib><creatorcontrib>Subhi‐Issa Ahmad, Issa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Diagnostic cytopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Díaz del Arco, Cristina</au><au>Ortega Medina, Luis</au><au>Subhi‐Issa Ahmad, Issa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retroperitoneal ectopic brain: Case report and literature review</atitle><jtitle>Diagnostic cytopathology</jtitle><addtitle>Diagn Cytopathol</addtitle><date>2018-06</date><risdate>2018</risdate><volume>46</volume><issue>6</issue><spage>528</spage><epage>531</epage><pages>528-531</pages><issn>8755-1039</issn><eissn>1097-0339</eissn><abstract>Heterotopic neural tissue (HNT) has been identified in many sites. In our literature review, we have found only two cases of HNT located in the retroperitoneum. As far as we know, cytological features of HNT have not been described. We here report a case of retroperitoneal HNT diagnosed by fine‐needle aspiration (FNA) cytology and subsequent resection. Our patient was a male infant born at 26 weeks’ gestation. A retroperitoneal solid‐cystic lesion measuring 3.8 cm was identified by abdominal ultrasound. FNA was performed and cytology showed highly cellular smears with single cells and masses of fibrillary material. Cells were small with rounded irregular nuclei and variable cytoplasm. Multinucleated cells, cells with neuronal morphology, calcifications, and hemosiderophages could also be seen. The lesion was excised and histology showed fibrillary areas, glial cells, neurons, and ependymal cells. Synaptophysin, GFAP, and EMA were expressed in distinct areas and cell types. 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| subjects | Biomarkers - metabolism Biopsy, Fine-Needle Brain Case reports Cellular biology Choristoma - diagnostic imaging Choristoma - pathology Cytology Cytoplasm ectopic brain ectopic neural tissue Ependymal cells fine‐needle aspiration cytology Gestation Glial cells Glial fibrillary acidic protein glial heterotopia Histology Humans Infant, Extremely Premature Infant, Newborn Literature reviews Male Neuronal-glial interactions Nuclei (cytology) Peritoneal Diseases - diagnostic imaging Peritoneal Diseases - pathology Retroperitoneal Space - diagnostic imaging Retroperitoneal Space - pathology Retroperitoneum Synaptophysin |
| title | Retroperitoneal ectopic brain: Case report and literature review |
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