Sleep spindles and slow waves in schizophrenia and related disorders: main findings, challenges and future perspectives
Sleep abnormalities have recently gained renewed attention in patients diagnosed with schizophrenia. Disrupted thalamocortical brain oscillations hold promise as putative biomarkers or endophenotypes of the disorder. Despite an increase in studies related to sleep spindle and slow‐wave activity, fin...
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Veröffentlicht in: | The European journal of neuroscience 2018-10, Vol.48 (8), p.2738-2758 |
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description | Sleep abnormalities have recently gained renewed attention in patients diagnosed with schizophrenia. Disrupted thalamocortical brain oscillations hold promise as putative biomarkers or endophenotypes of the disorder. Despite an increase in studies related to sleep spindle and slow‐wave activity, findings remain in part contradictory. Although sleep spindle deficits have been confirmed in several groups of patients with chronic, medicated schizophrenia, data on the early stages of the disorder and in unmedicated subjects are still insufficient. Findings on slow‐wave abnormalities are largely inconclusive, possibly due to the different criteria employed to define the phenomenon and to the influence of atypical antipsychotics. In this review, we aim to address the methodological and practical issues that may have limited the consistency of findings across research groups and different patient populations. Given the neurobiological relevance of these oscillations, which reflect the integrity of thalamocortical and cortico‐cortical function, research in this domain should be encouraged. To promote widespread consensus over the scientific and clinical implications of these sleep‐related phenomena, we advocate uniform and sound methodological approaches. These should encompass electroencephalographic recording and analysis techniques but also selection criteria and characterization of clinical populations.
We review recent evidence that disrupted brain oscillations during sleep are putative endophenotypes of Schizophrenia. Whereas sleep spindle deficits have been confirmed in several groups of patients with chronic, medicated Schizophrenia, findings on slow‐wave abnormalities are largely inconclusive, possibly due to the influence of atypical antipsychotics. Uniformity of EEG recording and analysis techniques but also selection criteria and characterization of clinical populations is necessary to advance knowledge in this fast‐growing field. |
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We review recent evidence that disrupted brain oscillations during sleep are putative endophenotypes of Schizophrenia. Whereas sleep spindle deficits have been confirmed in several groups of patients with chronic, medicated Schizophrenia, findings on slow‐wave abnormalities are largely inconclusive, possibly due to the influence of atypical antipsychotics. Uniformity of EEG recording and analysis techniques but also selection criteria and characterization of clinical populations is necessary to advance knowledge in this fast‐growing field.</description><identifier>ISSN: 0953-816X</identifier><identifier>EISSN: 1460-9568</identifier><identifier>DOI: 10.1111/ejn.13815</identifier><identifier>PMID: 29280209</identifier><language>eng</language><publisher>France: Wiley Subscription Services, Inc</publisher><subject>Activity patterns ; Antipsychotics ; brain oscillations ; Cerebral cortex ; EEG ; endophenotype ; Mental disorders ; Oscillations ; psychosis ; Schizophrenia ; Sleep ; Thalamus</subject><ispartof>The European journal of neuroscience, 2018-10, Vol.48 (8), p.2738-2758</ispartof><rights>2017 Federation of European Neuroscience Societies and John Wiley & Sons Ltd</rights><rights>2017 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.</rights><rights>Copyright © 2018 Federation of European Neuroscience Societies and John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3535-2541688916bed6a1b42f7afaf79977d811f39b72b5d0cfcdde8d878d982a30ea3</citedby><cites>FETCH-LOGICAL-c3535-2541688916bed6a1b42f7afaf79977d811f39b72b5d0cfcdde8d878d982a30ea3</cites><orcidid>0000-0002-2126-799X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fejn.13815$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fejn.13815$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29280209$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Castelnovo, Anna</creatorcontrib><creatorcontrib>Graziano, Bianca</creatorcontrib><creatorcontrib>Ferrarelli, Fabio</creatorcontrib><creatorcontrib>D'Agostino, Armando</creatorcontrib><title>Sleep spindles and slow waves in schizophrenia and related disorders: main findings, challenges and future perspectives</title><title>The European journal of neuroscience</title><addtitle>Eur J Neurosci</addtitle><description>Sleep abnormalities have recently gained renewed attention in patients diagnosed with schizophrenia. Disrupted thalamocortical brain oscillations hold promise as putative biomarkers or endophenotypes of the disorder. Despite an increase in studies related to sleep spindle and slow‐wave activity, findings remain in part contradictory. Although sleep spindle deficits have been confirmed in several groups of patients with chronic, medicated schizophrenia, data on the early stages of the disorder and in unmedicated subjects are still insufficient. Findings on slow‐wave abnormalities are largely inconclusive, possibly due to the different criteria employed to define the phenomenon and to the influence of atypical antipsychotics. In this review, we aim to address the methodological and practical issues that may have limited the consistency of findings across research groups and different patient populations. Given the neurobiological relevance of these oscillations, which reflect the integrity of thalamocortical and cortico‐cortical function, research in this domain should be encouraged. To promote widespread consensus over the scientific and clinical implications of these sleep‐related phenomena, we advocate uniform and sound methodological approaches. These should encompass electroencephalographic recording and analysis techniques but also selection criteria and characterization of clinical populations.
We review recent evidence that disrupted brain oscillations during sleep are putative endophenotypes of Schizophrenia. Whereas sleep spindle deficits have been confirmed in several groups of patients with chronic, medicated Schizophrenia, findings on slow‐wave abnormalities are largely inconclusive, possibly due to the influence of atypical antipsychotics. Uniformity of EEG recording and analysis techniques but also selection criteria and characterization of clinical populations is necessary to advance knowledge in this fast‐growing field.</description><subject>Activity patterns</subject><subject>Antipsychotics</subject><subject>brain oscillations</subject><subject>Cerebral cortex</subject><subject>EEG</subject><subject>endophenotype</subject><subject>Mental disorders</subject><subject>Oscillations</subject><subject>psychosis</subject><subject>Schizophrenia</subject><subject>Sleep</subject><subject>Thalamus</subject><issn>0953-816X</issn><issn>1460-9568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp10U1LHDEYwPFQKnVre-gXkEAvLXQ0L5OZpLey2FYRPVSht5CZPHGzZDNjstNFP73RXXsQzCWE_PgT8iD0iZIjWtYxLOMR5ZKKN2hG64ZUSjTyLZoRJXglafN3H73PeUkIkU0t3qF9ppgkjKgZ2vwJACPOo482QMYmWpzDsMEb868cfcS5X_j7YVwkiN483ScIZg0WW5-HZCHl73hlinSl4eNN_ob7hQkB4s0u6Kb1lACPhY7Qr30pf0B7zoQMH3f7Abr-eXI1_12dX_46nf84r3ouuKiYqGkjpaJNB7YxtKuZa40zrlWqba2k1HHVtawTlvSutxakla20SjLDCRh-gL5su2MabifIa73yuYcQTIRhypoqSYngdcsK_fyCLocpxfI6zSira8JFS4v6ulV9GnJO4PSY_MqkO02JfpyGLtPQT9Mo9nBXnLoV2P_y-fsLON6CjQ9w93pJn5xdbJMPOgqVNg</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Castelnovo, Anna</creator><creator>Graziano, Bianca</creator><creator>Ferrarelli, Fabio</creator><creator>D'Agostino, Armando</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2126-799X</orcidid></search><sort><creationdate>201810</creationdate><title>Sleep spindles and slow waves in schizophrenia and related disorders: main findings, challenges and future perspectives</title><author>Castelnovo, Anna ; Graziano, Bianca ; Ferrarelli, Fabio ; D'Agostino, Armando</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3535-2541688916bed6a1b42f7afaf79977d811f39b72b5d0cfcdde8d878d982a30ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Activity patterns</topic><topic>Antipsychotics</topic><topic>brain oscillations</topic><topic>Cerebral cortex</topic><topic>EEG</topic><topic>endophenotype</topic><topic>Mental disorders</topic><topic>Oscillations</topic><topic>psychosis</topic><topic>Schizophrenia</topic><topic>Sleep</topic><topic>Thalamus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Castelnovo, Anna</creatorcontrib><creatorcontrib>Graziano, Bianca</creatorcontrib><creatorcontrib>Ferrarelli, Fabio</creatorcontrib><creatorcontrib>D'Agostino, Armando</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The European journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Castelnovo, Anna</au><au>Graziano, Bianca</au><au>Ferrarelli, Fabio</au><au>D'Agostino, Armando</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sleep spindles and slow waves in schizophrenia and related disorders: main findings, challenges and future perspectives</atitle><jtitle>The European journal of neuroscience</jtitle><addtitle>Eur J Neurosci</addtitle><date>2018-10</date><risdate>2018</risdate><volume>48</volume><issue>8</issue><spage>2738</spage><epage>2758</epage><pages>2738-2758</pages><issn>0953-816X</issn><eissn>1460-9568</eissn><abstract>Sleep abnormalities have recently gained renewed attention in patients diagnosed with schizophrenia. Disrupted thalamocortical brain oscillations hold promise as putative biomarkers or endophenotypes of the disorder. Despite an increase in studies related to sleep spindle and slow‐wave activity, findings remain in part contradictory. Although sleep spindle deficits have been confirmed in several groups of patients with chronic, medicated schizophrenia, data on the early stages of the disorder and in unmedicated subjects are still insufficient. Findings on slow‐wave abnormalities are largely inconclusive, possibly due to the different criteria employed to define the phenomenon and to the influence of atypical antipsychotics. In this review, we aim to address the methodological and practical issues that may have limited the consistency of findings across research groups and different patient populations. Given the neurobiological relevance of these oscillations, which reflect the integrity of thalamocortical and cortico‐cortical function, research in this domain should be encouraged. To promote widespread consensus over the scientific and clinical implications of these sleep‐related phenomena, we advocate uniform and sound methodological approaches. These should encompass electroencephalographic recording and analysis techniques but also selection criteria and characterization of clinical populations.
We review recent evidence that disrupted brain oscillations during sleep are putative endophenotypes of Schizophrenia. Whereas sleep spindle deficits have been confirmed in several groups of patients with chronic, medicated Schizophrenia, findings on slow‐wave abnormalities are largely inconclusive, possibly due to the influence of atypical antipsychotics. Uniformity of EEG recording and analysis techniques but also selection criteria and characterization of clinical populations is necessary to advance knowledge in this fast‐growing field.</abstract><cop>France</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29280209</pmid><doi>10.1111/ejn.13815</doi><tpages>21</tpages><orcidid>https://orcid.org/0000-0002-2126-799X</orcidid></addata></record> |
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subjects | Activity patterns Antipsychotics brain oscillations Cerebral cortex EEG endophenotype Mental disorders Oscillations psychosis Schizophrenia Sleep Thalamus |
title | Sleep spindles and slow waves in schizophrenia and related disorders: main findings, challenges and future perspectives |
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