Protective effect of cyanidin 3-O-β-d-glucoside on ochratoxin A-mediated damage in the rat

The aim of the present study was to verify whether the oral administration of cyanidin 3-O-β-d-glucoside (C3G) might counteract damage induced by chronic exposure (28 d) to ochratoxin A (OTA) in rats and if its effect may be mediated by haeme oxygenase-1 (HO-1). Forty male Sprague–Dawley rats, indiv...

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Veröffentlicht in:	British journal of nutrition 2007-11, Vol.98 (5), p.937-943
Hauptverfasser:	Giacomo, Claudia Di, Acquaviva, Rosaria, Piva, Andrea, Sorrenti, Valeria, Vanella, Luca, Piva, Gianfranco, Casadei, Gabriele, Fauci, Luca La, Ritieni, Alberto, Bognanno, Matteo, Renzo, Laura Di, Barcellona, Maria L., Morlacchini, Mauro, Galvano, Fabio
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models Animals Anthocyanins - pharmacology Antioxidants - pharmacology Biological and medical sciences Brain - drug effects Brain - metabolism Carcinogens - antagonists & inhibitors Carcinogens - toxicity cyanidin cyanidin 3-)-beta-D-glucoside Cyanidin-3-O-β-glucoside dietary supplements DNA damage DNA Fragmentation - drug effects Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Glucosides - pharmacology Haeme oxygenase-1 Heme Oxygenase-1 - metabolism Kidney - drug effects Kidney - metabolism Lipid hydroperoxides lipid peroxidation Lipid Peroxidation - drug effects Lipid Peroxides - metabolism Liver - drug effects Liver - metabolism Male Non-proteic thiol groups ochratoxicosis Ochratoxin A Ochratoxins - antagonists & inhibitors Ochratoxins - toxicity oxidative stress oxygenases protective effect Rats Rats, Sprague-Dawley Sulfhydryl Compounds - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems
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