CpG island methylator phenotype (CIMP) in cancer: Causes and implications

Abstract Strong evidence exists for a subgroup of tumours, from a variety of tissue types, exhibiting concordant tumour specific DNA methylation: the “CpG island methylator phenotype” (CIMP). Occurrence of CIMP is associated with a range of genetic and environmental factors, although the molecular c...

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Veröffentlicht in:	Cancer letters 2008-09, Vol.268 (2), p.177-186
Hauptverfasser:	Teodoridis, Jens M, Hardie, Catriona, Brown, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired methylation Animals Cancer Cancer therapies Cell cycle Chemotherapy CIMP CpG island methylator phenotype CpG Islands Deoxyribonucleic acid DNA DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - physiology DNA Methylation DNMT Genes Genotype & phenotype Hematology, Oncology and Palliative Medicine Humans Medical prognosis Mutation Neoplasms - drug therapy Neoplasms - genetics Ovarian cancer Phenotype Prognosis Tumors
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