Histological alterations in ovaries of pubertal female rats induced by triphenyltin
Triphenyltin is an organotin compound that has been used extensively as an antifouling biocide and as an agricultural pesticide. Certain organotin compounds act as endocrine-active agents and have been reported to affect reproduction in mollusks and mammals. Here we studied the histopathological eff...
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| Veröffentlicht in: | Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2008-08, Vol.60 (4), p.313-321 |
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| container_title | Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie |
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| creator | Watermann, B. Grote, K. Gnass, K. Kolodzey, H. Thomsen, A. Appel, K.E. Candia-Carnevali, D. Schulte-Oehlmann, U. |
| description | Triphenyltin is an organotin compound that has been used extensively as an antifouling biocide and as an agricultural pesticide. Certain organotin compounds act as endocrine-active agents and have been reported to affect reproduction in mollusks and mammals. Here we studied the histopathological effects of 2 or 6
mg triphenyltin chloride (TPTCl)/kg b.w. on the reproductive tissue and the thymus of female pubertal rats as part of a comprehensive pubertal assay. Beginning at postnatal day (PND) 23 female Wistar rats were treated daily per gavage until their first estrus after PND 53. Reproductive organs were removed and histologically evaluated. While no histological changes were observed in oviduct, uterus, vagina and mamma, an increase in the number of all follicle stages occurred at both dose levels. Furthermore, exposure to 2
mg TPTCl/kg b.w. led to a significant reduction in the diameter of tertiary follicles. A significant increase in the number of atretic follicles was observed in tertiary and preovulatory follicles after exposure to 6
mg TPTCl. The thymus displayed a decreased number of apoptotic cells in both dose groups. We conclude that peripubertal administration of 2 and 6
mg TPTCl/kg b.w. caused effects on ovarian follicles of female rats. |
| doi_str_mv | 10.1016/j.etp.2008.03.009 |
| format | Article |
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mg triphenyltin chloride (TPTCl)/kg b.w. on the reproductive tissue and the thymus of female pubertal rats as part of a comprehensive pubertal assay. Beginning at postnatal day (PND) 23 female Wistar rats were treated daily per gavage until their first estrus after PND 53. Reproductive organs were removed and histologically evaluated. While no histological changes were observed in oviduct, uterus, vagina and mamma, an increase in the number of all follicle stages occurred at both dose levels. Furthermore, exposure to 2
mg TPTCl/kg b.w. led to a significant reduction in the diameter of tertiary follicles. A significant increase in the number of atretic follicles was observed in tertiary and preovulatory follicles after exposure to 6
mg TPTCl. The thymus displayed a decreased number of apoptotic cells in both dose groups. We conclude that peripubertal administration of 2 and 6
mg TPTCl/kg b.w. caused effects on ovarian follicles of female rats.</description><identifier>ISSN: 0940-2993</identifier><identifier>EISSN: 1618-1433</identifier><identifier>DOI: 10.1016/j.etp.2008.03.009</identifier><identifier>PMID: 18513932</identifier><language>eng</language><publisher>Jena: Elsevier GmbH</publisher><subject>Animals ; Anti-Infective Agents - toxicity ; Biological and medical sciences ; Endocrine-active compounds ; Female ; Female rat ; Immunohistochemistry ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; Mollusca ; Organotin Compounds - toxicity ; Ovary ; Ovary - drug effects ; Ovary - pathology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Puberty ; Rats ; Rats, Wistar ; Reproduction ; Thymus Gland - drug effects ; Thymus Gland - pathology ; Triphenyltin</subject><ispartof>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 2008-08, Vol.60 (4), p.313-321</ispartof><rights>2008 Elsevier GmbH</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-b4e81c87d8fc7578640805e31874719bb0785ecfe270ddde4d329941688b29a93</citedby><cites>FETCH-LOGICAL-c412t-b4e81c87d8fc7578640805e31874719bb0785ecfe270ddde4d329941688b29a93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.etp.2008.03.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20525730$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18513932$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Watermann, B.</creatorcontrib><creatorcontrib>Grote, K.</creatorcontrib><creatorcontrib>Gnass, K.</creatorcontrib><creatorcontrib>Kolodzey, H.</creatorcontrib><creatorcontrib>Thomsen, A.</creatorcontrib><creatorcontrib>Appel, K.E.</creatorcontrib><creatorcontrib>Candia-Carnevali, D.</creatorcontrib><creatorcontrib>Schulte-Oehlmann, U.</creatorcontrib><title>Histological alterations in ovaries of pubertal female rats induced by triphenyltin</title><title>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie</title><addtitle>Exp Toxicol Pathol</addtitle><description>Triphenyltin is an organotin compound that has been used extensively as an antifouling biocide and as an agricultural pesticide. Certain organotin compounds act as endocrine-active agents and have been reported to affect reproduction in mollusks and mammals. Here we studied the histopathological effects of 2 or 6
mg triphenyltin chloride (TPTCl)/kg b.w. on the reproductive tissue and the thymus of female pubertal rats as part of a comprehensive pubertal assay. Beginning at postnatal day (PND) 23 female Wistar rats were treated daily per gavage until their first estrus after PND 53. Reproductive organs were removed and histologically evaluated. While no histological changes were observed in oviduct, uterus, vagina and mamma, an increase in the number of all follicle stages occurred at both dose levels. Furthermore, exposure to 2
mg TPTCl/kg b.w. led to a significant reduction in the diameter of tertiary follicles. A significant increase in the number of atretic follicles was observed in tertiary and preovulatory follicles after exposure to 6
mg TPTCl. The thymus displayed a decreased number of apoptotic cells in both dose groups. We conclude that peripubertal administration of 2 and 6
mg TPTCl/kg b.w. caused effects on ovarian follicles of female rats.</description><subject>Animals</subject><subject>Anti-Infective Agents - toxicity</subject><subject>Biological and medical sciences</subject><subject>Endocrine-active compounds</subject><subject>Female</subject><subject>Female rat</subject><subject>Immunohistochemistry</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>Mollusca</subject><subject>Organotin Compounds - toxicity</subject><subject>Ovary</subject><subject>Ovary - drug effects</subject><subject>Ovary - pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Puberty</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reproduction</subject><subject>Thymus Gland - drug effects</subject><subject>Thymus Gland - pathology</subject><subject>Triphenyltin</subject><issn>0940-2993</issn><issn>1618-1433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90E1P3DAQgGELFcFC-wN6qXJpbwnjj2xscaoQBSQkDi1ny7EnrVfZONgO0v57vNoVvXHy5ZnR-CXkK4WGAl1fbRrMc8MAZAO8AVAnZEXXVNZUcP6JrEAJqJlS_JxcpLQBYKBaekbOqWwpV5ytyO97n3IYw19vzViZMWM02YcpVX6qwquJHlMVhmpeeoy5kAG3ZsSqqD1xi0VX9bsqRz__w2k3Zj99JqeDGRN-Ob6X5PnX7Z-b-_rx6e7h5udjbQVlue4FSmpl5-Rgu7aTawESWuRUdqKjqu-hky3aAVkHzjkUjpe_CLqWsmfKKH5Jfhz2zjG8LJiy3vpkcRzNhGFJmioJkreiQHqANoaUIg56jn5r4k5T0PuSeqNLSb0vqYHrUrLMfDsuX_otuv8Tx3QFfD8Ck0q7IZrJ-vTuGLSs7TgUd31wWFK8eow6WY9T6eYj2qxd8B-c8QbD5JER</recordid><startdate>20080801</startdate><enddate>20080801</enddate><creator>Watermann, B.</creator><creator>Grote, K.</creator><creator>Gnass, K.</creator><creator>Kolodzey, H.</creator><creator>Thomsen, A.</creator><creator>Appel, K.E.</creator><creator>Candia-Carnevali, D.</creator><creator>Schulte-Oehlmann, U.</creator><general>Elsevier GmbH</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20080801</creationdate><title>Histological alterations in ovaries of pubertal female rats induced by triphenyltin</title><author>Watermann, B. ; Grote, K. ; Gnass, K. ; Kolodzey, H. ; Thomsen, A. ; Appel, K.E. ; Candia-Carnevali, D. ; Schulte-Oehlmann, U.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-b4e81c87d8fc7578640805e31874719bb0785ecfe270ddde4d329941688b29a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Anti-Infective Agents - toxicity</topic><topic>Biological and medical sciences</topic><topic>Endocrine-active compounds</topic><topic>Female</topic><topic>Female rat</topic><topic>Immunohistochemistry</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical sciences</topic><topic>Mollusca</topic><topic>Organotin Compounds - toxicity</topic><topic>Ovary</topic><topic>Ovary - drug effects</topic><topic>Ovary - pathology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Puberty</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reproduction</topic><topic>Thymus Gland - drug effects</topic><topic>Thymus Gland - pathology</topic><topic>Triphenyltin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Watermann, B.</creatorcontrib><creatorcontrib>Grote, K.</creatorcontrib><creatorcontrib>Gnass, K.</creatorcontrib><creatorcontrib>Kolodzey, H.</creatorcontrib><creatorcontrib>Thomsen, A.</creatorcontrib><creatorcontrib>Appel, K.E.</creatorcontrib><creatorcontrib>Candia-Carnevali, D.</creatorcontrib><creatorcontrib>Schulte-Oehlmann, U.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Watermann, B.</au><au>Grote, K.</au><au>Gnass, K.</au><au>Kolodzey, H.</au><au>Thomsen, A.</au><au>Appel, K.E.</au><au>Candia-Carnevali, D.</au><au>Schulte-Oehlmann, U.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histological alterations in ovaries of pubertal female rats induced by triphenyltin</atitle><jtitle>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie</jtitle><addtitle>Exp Toxicol Pathol</addtitle><date>2008-08-01</date><risdate>2008</risdate><volume>60</volume><issue>4</issue><spage>313</spage><epage>321</epage><pages>313-321</pages><issn>0940-2993</issn><eissn>1618-1433</eissn><abstract>Triphenyltin is an organotin compound that has been used extensively as an antifouling biocide and as an agricultural pesticide. Certain organotin compounds act as endocrine-active agents and have been reported to affect reproduction in mollusks and mammals. Here we studied the histopathological effects of 2 or 6
mg triphenyltin chloride (TPTCl)/kg b.w. on the reproductive tissue and the thymus of female pubertal rats as part of a comprehensive pubertal assay. Beginning at postnatal day (PND) 23 female Wistar rats were treated daily per gavage until their first estrus after PND 53. Reproductive organs were removed and histologically evaluated. While no histological changes were observed in oviduct, uterus, vagina and mamma, an increase in the number of all follicle stages occurred at both dose levels. Furthermore, exposure to 2
mg TPTCl/kg b.w. led to a significant reduction in the diameter of tertiary follicles. A significant increase in the number of atretic follicles was observed in tertiary and preovulatory follicles after exposure to 6
mg TPTCl. The thymus displayed a decreased number of apoptotic cells in both dose groups. We conclude that peripubertal administration of 2 and 6
mg TPTCl/kg b.w. caused effects on ovarian follicles of female rats.</abstract><cop>Jena</cop><pub>Elsevier GmbH</pub><pmid>18513932</pmid><doi>10.1016/j.etp.2008.03.009</doi><tpages>9</tpages></addata></record> |
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| subjects | Animals Anti-Infective Agents - toxicity Biological and medical sciences Endocrine-active compounds Female Female rat Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Medical sciences Mollusca Organotin Compounds - toxicity Ovary Ovary - drug effects Ovary - pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Puberty Rats Rats, Wistar Reproduction Thymus Gland - drug effects Thymus Gland - pathology Triphenyltin |
| title | Histological alterations in ovaries of pubertal female rats induced by triphenyltin |
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