Polymorphism of detoxification genes and cell resistance to mutagens in patients with Ehlers-Danlos syndrome
Study of polymorphism in 3 genes of the glutathione S-transferase family (GSTM1, GSTT1, and GSTP1) in children with Ehlers-Danlos syndrome whose cells were defective in repair of gamma-induced DNA damages revealed accumulation of GSTM1(+) genotypes compared to children of the control group. Generati...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2007-11, Vol.144 (5), p.717-721 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Kuz'mina, N S Shipaeva, E V Semyachkina, A N Vasil'eva, I M Kovalenko, L P Durnev, A D Zasukhina, G D |
| description | Study of polymorphism in 3 genes of the glutathione S-transferase family (GSTM1, GSTT1, and GSTP1) in children with Ehlers-Danlos syndrome whose cells were defective in repair of gamma-induced DNA damages revealed accumulation of GSTM1(+) genotypes compared to children of the control group. Generation of reactive oxygen species by neutrophils from patients with this syndrome was higher than in healthy donors. Our results indicate that glutathione S-transferase genes are involved in the resistance to mutagenic agents and demonstrate medical and genetic peculiarities of patients with Ehlers-Danlos syndrome. |
| doi_str_mv | 10.1007/s10517-007-0414-2 |
| format | Article |
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Generation of reactive oxygen species by neutrophils from patients with this syndrome was higher than in healthy donors. Our results indicate that glutathione S-transferase genes are involved in the resistance to mutagenic agents and demonstrate medical and genetic peculiarities of patients with Ehlers-Danlos syndrome.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-007-0414-2</identifier><identifier>PMID: 18683505</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Adolescent ; Cadmium Chloride - pharmacology ; Child ; DNA Damage ; Drug Resistance ; Ehlers-Danlos Syndrome - blood ; Ehlers-Danlos Syndrome - genetics ; Female ; Gamma Rays ; Gene Frequency ; Genetic Predisposition to Disease - genetics ; Genotype ; Glutathione Transferase - genetics ; Humans ; Lymphocytes - drug effects ; Lymphocytes - metabolism ; Lymphocytes - radiation effects ; Male ; Mutagens - pharmacology ; Polymorphism, Genetic ; Reactive Oxygen Species - metabolism</subject><ispartof>Bulletin of experimental biology and medicine, 2007-11, Vol.144 (5), p.717-721</ispartof><rights>Springer Science+Business Media, Inc. 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c366t-7d8c53637d1b9dd36ff04f8b640cb923b65fec6ce70117d6a59a8866193f1f243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18683505$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuz'mina, N S</creatorcontrib><creatorcontrib>Shipaeva, E V</creatorcontrib><creatorcontrib>Semyachkina, A N</creatorcontrib><creatorcontrib>Vasil'eva, I M</creatorcontrib><creatorcontrib>Kovalenko, L P</creatorcontrib><creatorcontrib>Durnev, A D</creatorcontrib><creatorcontrib>Zasukhina, G D</creatorcontrib><title>Polymorphism of detoxification genes and cell resistance to mutagens in patients with Ehlers-Danlos syndrome</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><description>Study of polymorphism in 3 genes of the glutathione S-transferase family (GSTM1, GSTT1, and GSTP1) in children with Ehlers-Danlos syndrome whose cells were defective in repair of gamma-induced DNA damages revealed accumulation of GSTM1(+) genotypes compared to children of the control group. 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| subjects | Adolescent Cadmium Chloride - pharmacology Child DNA Damage Drug Resistance Ehlers-Danlos Syndrome - blood Ehlers-Danlos Syndrome - genetics Female Gamma Rays Gene Frequency Genetic Predisposition to Disease - genetics Genotype Glutathione Transferase - genetics Humans Lymphocytes - drug effects Lymphocytes - metabolism Lymphocytes - radiation effects Male Mutagens - pharmacology Polymorphism, Genetic Reactive Oxygen Species - metabolism |
| title | Polymorphism of detoxification genes and cell resistance to mutagens in patients with Ehlers-Danlos syndrome |
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