Expression of programmed death ligand-1 on bladder tissues is detected in a clinically and histologically well-defined interstitial cystitis cohort
To investigate the expression of programmed death ligand-1 (PD-L1) in interstitial cystitis (IC). We reviewed the data of IC patients underwent hydrodistension plus bladder biopsy. Follow-ups were performed. We assessed the degree of inflammation of the bladder wall on slides stained with hematoxyli...
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| Veröffentlicht in: | Neurourology and urodynamics 2018-04, Vol.37 (4), p.1396-1404 |
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| container_title | Neurourology and urodynamics |
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| creator | Chen, Yuke Yu, Wei Yang, Yang Xiao, Yunxiang Cui, Yun Duan, Jihong He, Qun Jin, Jie Wu, Shiliang |
| description | To investigate the expression of programmed death ligand-1 (PD-L1) in interstitial cystitis (IC).
We reviewed the data of IC patients underwent hydrodistension plus bladder biopsy. Follow-ups were performed. We assessed the degree of inflammation of the bladder wall on slides stained with hematoxylin and eosin (H&E). We performed immunohistochemistry for PD-L1 expression detection and for counting T lymphocytes and B lymphocytes.
The present study included eight men and 32 women. With H&E staining, we detected 13, 15, and 12 patients with mild, moderate, and severe inflammation. The degree of inflammation was negatively correlated with disease course (P = 0.018) and positively correlated with bladder pain (P |
| doi_str_mv | 10.1002/nau.23459 |
| format | Article |
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We reviewed the data of IC patients underwent hydrodistension plus bladder biopsy. Follow-ups were performed. We assessed the degree of inflammation of the bladder wall on slides stained with hematoxylin and eosin (H&E). We performed immunohistochemistry for PD-L1 expression detection and for counting T lymphocytes and B lymphocytes.
The present study included eight men and 32 women. With H&E staining, we detected 13, 15, and 12 patients with mild, moderate, and severe inflammation. The degree of inflammation was negatively correlated with disease course (P = 0.018) and positively correlated with bladder pain (P < 0.001). Hydrodistension was found effective at postoperative 3-month for 19 patients. Overall, 17, 15, 7, and 1 subject had no, mild, moderate, and high PD-L1 expression, that correlated positively with the degree of inflammation. Compared with patients with no and mild PD-L1 expression, patients with moderate and high PD-L1 expression tended to have more effective hydrodistension outcomes (12 of 32 vs 7 of 8; P = 0.017). In the subset of 12 patients with severe inflammation, there were five of six patients (83.3%) with moderate or high PD-L1 expression and one of six patients (16.7%) with no and mild PD-L1 expression with an effective hydrodistension outcome.
Expression of PD-L1 on bladder is detected in a cohort of IC patients presented with diffuse global glomerulation or Hunner ulcer. PD-L1 expression is more common in IC patients with severe bladder inflammation.</description><identifier>ISSN: 0733-2467</identifier><identifier>EISSN: 1520-6777</identifier><identifier>DOI: 10.1002/nau.23459</identifier><identifier>PMID: 29277923</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Biopsy ; Bladder ; Cystitis ; Immunohistochemistry ; Inflammation ; Ligands ; Lymphocytes B ; Lymphocytes T ; Pain ; PD-L1 protein</subject><ispartof>Neurourology and urodynamics, 2018-04, Vol.37 (4), p.1396-1404</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c313t-196ef8cfbfd323aecf82aed1eb89c16dc50ee693787666eef3033a33a54aad843</citedby><cites>FETCH-LOGICAL-c313t-196ef8cfbfd323aecf82aed1eb89c16dc50ee693787666eef3033a33a54aad843</cites><orcidid>0000-0002-0712-9929</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29277923$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Yuke</creatorcontrib><creatorcontrib>Yu, Wei</creatorcontrib><creatorcontrib>Yang, Yang</creatorcontrib><creatorcontrib>Xiao, Yunxiang</creatorcontrib><creatorcontrib>Cui, Yun</creatorcontrib><creatorcontrib>Duan, Jihong</creatorcontrib><creatorcontrib>He, Qun</creatorcontrib><creatorcontrib>Jin, Jie</creatorcontrib><creatorcontrib>Wu, Shiliang</creatorcontrib><title>Expression of programmed death ligand-1 on bladder tissues is detected in a clinically and histologically well-defined interstitial cystitis cohort</title><title>Neurourology and urodynamics</title><addtitle>Neurourol Urodyn</addtitle><description>To investigate the expression of programmed death ligand-1 (PD-L1) in interstitial cystitis (IC).
We reviewed the data of IC patients underwent hydrodistension plus bladder biopsy. Follow-ups were performed. We assessed the degree of inflammation of the bladder wall on slides stained with hematoxylin and eosin (H&E). We performed immunohistochemistry for PD-L1 expression detection and for counting T lymphocytes and B lymphocytes.
The present study included eight men and 32 women. With H&E staining, we detected 13, 15, and 12 patients with mild, moderate, and severe inflammation. The degree of inflammation was negatively correlated with disease course (P = 0.018) and positively correlated with bladder pain (P < 0.001). Hydrodistension was found effective at postoperative 3-month for 19 patients. Overall, 17, 15, 7, and 1 subject had no, mild, moderate, and high PD-L1 expression, that correlated positively with the degree of inflammation. Compared with patients with no and mild PD-L1 expression, patients with moderate and high PD-L1 expression tended to have more effective hydrodistension outcomes (12 of 32 vs 7 of 8; P = 0.017). In the subset of 12 patients with severe inflammation, there were five of six patients (83.3%) with moderate or high PD-L1 expression and one of six patients (16.7%) with no and mild PD-L1 expression with an effective hydrodistension outcome.
Expression of PD-L1 on bladder is detected in a cohort of IC patients presented with diffuse global glomerulation or Hunner ulcer. PD-L1 expression is more common in IC patients with severe bladder inflammation.</description><subject>Biopsy</subject><subject>Bladder</subject><subject>Cystitis</subject><subject>Immunohistochemistry</subject><subject>Inflammation</subject><subject>Ligands</subject><subject>Lymphocytes B</subject><subject>Lymphocytes T</subject><subject>Pain</subject><subject>PD-L1 protein</subject><issn>0733-2467</issn><issn>1520-6777</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpdkc1OHDEMx6OqqGyhh74AitQLPQwk8cxkcqwQ_ZCQuMB5lE2c3aDsZEkygn2OvjBhWXqoZMmW_bNl-0_IV84uOGPictLzhYC2Ux_IgneCNb2U8iNZMAnQiLaXx-Rzzg-MsQFa9YkcCyWkVAIW5O_18zZhzj5ONDq6TXGV9GaDllrUZU2DX-nJNpzW-jJoazHR4nOeMVOfK1TQlEr7iWpqgp-80SHsaG2ia59LDHF1SD1hCI1F56c9XzDl4ovXgZrdPsrUxHVM5ZQcOR0yfjn4E3L_8_ru6ndzc_vrz9WPm8YAh9Jw1aMbjFs6CwI0GjcIjZbjclCG99Z0DLFXIAfZ9z2iAwagq3Wt1nZo4YScv82tVz_Wg8q48dnULfWEcc4jVwProJPdK_rtP_Qhzmmq242CAW-h5a2q1Pc3yqSYc0I3bpPf6LQbORtflRqrUuNeqcqeHSbOy_ruf-S7NPACvm6R6A</recordid><startdate>201804</startdate><enddate>201804</enddate><creator>Chen, Yuke</creator><creator>Yu, Wei</creator><creator>Yang, Yang</creator><creator>Xiao, Yunxiang</creator><creator>Cui, Yun</creator><creator>Duan, Jihong</creator><creator>He, Qun</creator><creator>Jin, Jie</creator><creator>Wu, Shiliang</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0712-9929</orcidid></search><sort><creationdate>201804</creationdate><title>Expression of programmed death ligand-1 on bladder tissues is detected in a clinically and histologically well-defined interstitial cystitis cohort</title><author>Chen, Yuke ; Yu, Wei ; Yang, Yang ; Xiao, Yunxiang ; Cui, Yun ; Duan, Jihong ; He, Qun ; Jin, Jie ; Wu, Shiliang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c313t-196ef8cfbfd323aecf82aed1eb89c16dc50ee693787666eef3033a33a54aad843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Biopsy</topic><topic>Bladder</topic><topic>Cystitis</topic><topic>Immunohistochemistry</topic><topic>Inflammation</topic><topic>Ligands</topic><topic>Lymphocytes B</topic><topic>Lymphocytes T</topic><topic>Pain</topic><topic>PD-L1 protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Yuke</creatorcontrib><creatorcontrib>Yu, Wei</creatorcontrib><creatorcontrib>Yang, Yang</creatorcontrib><creatorcontrib>Xiao, Yunxiang</creatorcontrib><creatorcontrib>Cui, Yun</creatorcontrib><creatorcontrib>Duan, Jihong</creatorcontrib><creatorcontrib>He, Qun</creatorcontrib><creatorcontrib>Jin, Jie</creatorcontrib><creatorcontrib>Wu, Shiliang</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Neurourology and urodynamics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Yuke</au><au>Yu, Wei</au><au>Yang, Yang</au><au>Xiao, Yunxiang</au><au>Cui, Yun</au><au>Duan, Jihong</au><au>He, Qun</au><au>Jin, Jie</au><au>Wu, Shiliang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of programmed death ligand-1 on bladder tissues is detected in a clinically and histologically well-defined interstitial cystitis cohort</atitle><jtitle>Neurourology and urodynamics</jtitle><addtitle>Neurourol Urodyn</addtitle><date>2018-04</date><risdate>2018</risdate><volume>37</volume><issue>4</issue><spage>1396</spage><epage>1404</epage><pages>1396-1404</pages><issn>0733-2467</issn><eissn>1520-6777</eissn><abstract>To investigate the expression of programmed death ligand-1 (PD-L1) in interstitial cystitis (IC).
We reviewed the data of IC patients underwent hydrodistension plus bladder biopsy. Follow-ups were performed. We assessed the degree of inflammation of the bladder wall on slides stained with hematoxylin and eosin (H&E). We performed immunohistochemistry for PD-L1 expression detection and for counting T lymphocytes and B lymphocytes.
The present study included eight men and 32 women. With H&E staining, we detected 13, 15, and 12 patients with mild, moderate, and severe inflammation. The degree of inflammation was negatively correlated with disease course (P = 0.018) and positively correlated with bladder pain (P < 0.001). Hydrodistension was found effective at postoperative 3-month for 19 patients. Overall, 17, 15, 7, and 1 subject had no, mild, moderate, and high PD-L1 expression, that correlated positively with the degree of inflammation. Compared with patients with no and mild PD-L1 expression, patients with moderate and high PD-L1 expression tended to have more effective hydrodistension outcomes (12 of 32 vs 7 of 8; P = 0.017). In the subset of 12 patients with severe inflammation, there were five of six patients (83.3%) with moderate or high PD-L1 expression and one of six patients (16.7%) with no and mild PD-L1 expression with an effective hydrodistension outcome.
Expression of PD-L1 on bladder is detected in a cohort of IC patients presented with diffuse global glomerulation or Hunner ulcer. PD-L1 expression is more common in IC patients with severe bladder inflammation.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29277923</pmid><doi>10.1002/nau.23459</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-0712-9929</orcidid></addata></record> |
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| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Biopsy Bladder Cystitis Immunohistochemistry Inflammation Ligands Lymphocytes B Lymphocytes T Pain PD-L1 protein |
| title | Expression of programmed death ligand-1 on bladder tissues is detected in a clinically and histologically well-defined interstitial cystitis cohort |
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