Analysis of Urine Proteome in Patients With Postinfarction Cardiosclerosis Combined With Hypertensive Disease for Assessing Endothelial Dysfunction
In our study urine protein composition of 18 healthy volunteers was compared with that of 18 patients with ischemic heart disease and concomitant hypertension. Liquid chromatography-mass-spectrometry (LC-MS) analysis of the second fraction of morning urine was carried out using nano-line high perfor...
Gespeichert in:
| Veröffentlicht in: | Kardiologiia 2017-11, Vol.57 (11), p.49-58 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | rus |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 58 |
|---|---|
| container_issue | 11 |
| container_start_page | 49 |
| container_title | Kardiologiia |
| container_volume | 57 |
| creator | Masenko, V P Pastushkova, L K Kashirina, D N Dobrokhotov, I V Kononikhin, A S Tiys, E S Ivanisenko, V A Veselova, O M Vyborov, O N Nosovskiy, A M Goncharov, I N Nikolaev, E N Larina, I M |
| description | In our study urine protein composition of 18 healthy volunteers was compared with that of 18 patients with ischemic heart disease and concomitant hypertension. Liquid chromatography-mass-spectrometry (LC-MS) analysis of the second fraction of morning urine was carried out using nano-line high performance liquid chromatograph and hybrid mass spectrometer. The analysis revealed 23 proteins expressed in the endothelium, according to the information contained in the database Bgee, and 49 proteins, with direct functional link with the processes in the endothelium in the reconstruction of associative networks using ANDSystem program. Comparison of urine proteome of healthy people and patients with postinfarction cardiosclerosis revealed proteins specific for patients with cardiovascular disease. Thus, proteins vitronectin, syndecan-4, a histidine rich glycoprotein, endothelial protein C receptor, colony stimulating factor, cathepsin D and sekretogranin-1 may be considered as potential markers for cardiovascular diseases. Further research in this area should be conducted for clinical and experimental verification of these hypotheses. |
| doi_str_mv | 10.10087/cardio.2017.11.10054 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1980534999</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1980534999</sourcerecordid><originalsourceid>FETCH-LOGICAL-p141t-5e0f577b45ccf9c01154e31011ea92f7a3329855132ccfed2ab00b56af9c153c3</originalsourceid><addsrcrecordid>eNo1kMtOwzAQRb0A0ar0E0BesmnxI27iZdUWilSJLqhYVk4yoZYSO3hcpHwHP0z6YHWl0dG5o0vIA2dTzliWPhcmlNZPBePplPPTUSU3ZMiYEBPNEjYgY0SbMzZTqUyUuiMDoUU60zwbkt-5M3WHFqmv6C5YB3QbfATfALWObk204CLSTxsPdOsxWleZUETrHV2ci7GoIfiTYeGbvBeUF3jdtRAiOLQ_QJcWwSDQygc6R4T-IfdFV6708QC1NTVddlgd3Vl8T24rUyOMrzkiu5fVx2I92by_vi3mm0nLEx4nClil0jRPVFFUumCcqwQk7xOMFlVqpBQ6U4pL0QNQCtNvkKuZ6WGuZCFH5OnibYP_PgLGfWOxgLo2DvwR91xnTMlEa92jj1f0mDdQ7ttgGxO6_f-Q8g9esXmT</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1980534999</pqid></control><display><type>article</type><title>Analysis of Urine Proteome in Patients With Postinfarction Cardiosclerosis Combined With Hypertensive Disease for Assessing Endothelial Dysfunction</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Masenko, V P ; Pastushkova, L K ; Kashirina, D N ; Dobrokhotov, I V ; Kononikhin, A S ; Tiys, E S ; Ivanisenko, V A ; Veselova, O M ; Vyborov, O N ; Nosovskiy, A M ; Goncharov, I N ; Nikolaev, E N ; Larina, I M</creator><creatorcontrib>Masenko, V P ; Pastushkova, L K ; Kashirina, D N ; Dobrokhotov, I V ; Kononikhin, A S ; Tiys, E S ; Ivanisenko, V A ; Veselova, O M ; Vyborov, O N ; Nosovskiy, A M ; Goncharov, I N ; Nikolaev, E N ; Larina, I M</creatorcontrib><description>In our study urine protein composition of 18 healthy volunteers was compared with that of 18 patients with ischemic heart disease and concomitant hypertension. Liquid chromatography-mass-spectrometry (LC-MS) analysis of the second fraction of morning urine was carried out using nano-line high performance liquid chromatograph and hybrid mass spectrometer. The analysis revealed 23 proteins expressed in the endothelium, according to the information contained in the database Bgee, and 49 proteins, with direct functional link with the processes in the endothelium in the reconstruction of associative networks using ANDSystem program. Comparison of urine proteome of healthy people and patients with postinfarction cardiosclerosis revealed proteins specific for patients with cardiovascular disease. Thus, proteins vitronectin, syndecan-4, a histidine rich glycoprotein, endothelial protein C receptor, colony stimulating factor, cathepsin D and sekretogranin-1 may be considered as potential markers for cardiovascular diseases. Further research in this area should be conducted for clinical and experimental verification of these hypotheses.</description><identifier>ISSN: 0022-9040</identifier><identifier>DOI: 10.10087/cardio.2017.11.10054</identifier><identifier>PMID: 29276918</identifier><language>rus</language><publisher>Russia (Federation)</publisher><ispartof>Kardiologiia, 2017-11, Vol.57 (11), p.49-58</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29276918$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Masenko, V P</creatorcontrib><creatorcontrib>Pastushkova, L K</creatorcontrib><creatorcontrib>Kashirina, D N</creatorcontrib><creatorcontrib>Dobrokhotov, I V</creatorcontrib><creatorcontrib>Kononikhin, A S</creatorcontrib><creatorcontrib>Tiys, E S</creatorcontrib><creatorcontrib>Ivanisenko, V A</creatorcontrib><creatorcontrib>Veselova, O M</creatorcontrib><creatorcontrib>Vyborov, O N</creatorcontrib><creatorcontrib>Nosovskiy, A M</creatorcontrib><creatorcontrib>Goncharov, I N</creatorcontrib><creatorcontrib>Nikolaev, E N</creatorcontrib><creatorcontrib>Larina, I M</creatorcontrib><title>Analysis of Urine Proteome in Patients With Postinfarction Cardiosclerosis Combined With Hypertensive Disease for Assessing Endothelial Dysfunction</title><title>Kardiologiia</title><addtitle>Kardiologiia</addtitle><description>In our study urine protein composition of 18 healthy volunteers was compared with that of 18 patients with ischemic heart disease and concomitant hypertension. Liquid chromatography-mass-spectrometry (LC-MS) analysis of the second fraction of morning urine was carried out using nano-line high performance liquid chromatograph and hybrid mass spectrometer. The analysis revealed 23 proteins expressed in the endothelium, according to the information contained in the database Bgee, and 49 proteins, with direct functional link with the processes in the endothelium in the reconstruction of associative networks using ANDSystem program. Comparison of urine proteome of healthy people and patients with postinfarction cardiosclerosis revealed proteins specific for patients with cardiovascular disease. Thus, proteins vitronectin, syndecan-4, a histidine rich glycoprotein, endothelial protein C receptor, colony stimulating factor, cathepsin D and sekretogranin-1 may be considered as potential markers for cardiovascular diseases. Further research in this area should be conducted for clinical and experimental verification of these hypotheses.</description><issn>0022-9040</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNo1kMtOwzAQRb0A0ar0E0BesmnxI27iZdUWilSJLqhYVk4yoZYSO3hcpHwHP0z6YHWl0dG5o0vIA2dTzliWPhcmlNZPBePplPPTUSU3ZMiYEBPNEjYgY0SbMzZTqUyUuiMDoUU60zwbkt-5M3WHFqmv6C5YB3QbfATfALWObk204CLSTxsPdOsxWleZUETrHV2ci7GoIfiTYeGbvBeUF3jdtRAiOLQ_QJcWwSDQygc6R4T-IfdFV6708QC1NTVddlgd3Vl8T24rUyOMrzkiu5fVx2I92by_vi3mm0nLEx4nClil0jRPVFFUumCcqwQk7xOMFlVqpBQ6U4pL0QNQCtNvkKuZ6WGuZCFH5OnibYP_PgLGfWOxgLo2DvwR91xnTMlEa92jj1f0mDdQ7ttgGxO6_f-Q8g9esXmT</recordid><startdate>201711</startdate><enddate>201711</enddate><creator>Masenko, V P</creator><creator>Pastushkova, L K</creator><creator>Kashirina, D N</creator><creator>Dobrokhotov, I V</creator><creator>Kononikhin, A S</creator><creator>Tiys, E S</creator><creator>Ivanisenko, V A</creator><creator>Veselova, O M</creator><creator>Vyborov, O N</creator><creator>Nosovskiy, A M</creator><creator>Goncharov, I N</creator><creator>Nikolaev, E N</creator><creator>Larina, I M</creator><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201711</creationdate><title>Analysis of Urine Proteome in Patients With Postinfarction Cardiosclerosis Combined With Hypertensive Disease for Assessing Endothelial Dysfunction</title><author>Masenko, V P ; Pastushkova, L K ; Kashirina, D N ; Dobrokhotov, I V ; Kononikhin, A S ; Tiys, E S ; Ivanisenko, V A ; Veselova, O M ; Vyborov, O N ; Nosovskiy, A M ; Goncharov, I N ; Nikolaev, E N ; Larina, I M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p141t-5e0f577b45ccf9c01154e31011ea92f7a3329855132ccfed2ab00b56af9c153c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>rus</language><creationdate>2017</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Masenko, V P</creatorcontrib><creatorcontrib>Pastushkova, L K</creatorcontrib><creatorcontrib>Kashirina, D N</creatorcontrib><creatorcontrib>Dobrokhotov, I V</creatorcontrib><creatorcontrib>Kononikhin, A S</creatorcontrib><creatorcontrib>Tiys, E S</creatorcontrib><creatorcontrib>Ivanisenko, V A</creatorcontrib><creatorcontrib>Veselova, O M</creatorcontrib><creatorcontrib>Vyborov, O N</creatorcontrib><creatorcontrib>Nosovskiy, A M</creatorcontrib><creatorcontrib>Goncharov, I N</creatorcontrib><creatorcontrib>Nikolaev, E N</creatorcontrib><creatorcontrib>Larina, I M</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Kardiologiia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Masenko, V P</au><au>Pastushkova, L K</au><au>Kashirina, D N</au><au>Dobrokhotov, I V</au><au>Kononikhin, A S</au><au>Tiys, E S</au><au>Ivanisenko, V A</au><au>Veselova, O M</au><au>Vyborov, O N</au><au>Nosovskiy, A M</au><au>Goncharov, I N</au><au>Nikolaev, E N</au><au>Larina, I M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of Urine Proteome in Patients With Postinfarction Cardiosclerosis Combined With Hypertensive Disease for Assessing Endothelial Dysfunction</atitle><jtitle>Kardiologiia</jtitle><addtitle>Kardiologiia</addtitle><date>2017-11</date><risdate>2017</risdate><volume>57</volume><issue>11</issue><spage>49</spage><epage>58</epage><pages>49-58</pages><issn>0022-9040</issn><abstract>In our study urine protein composition of 18 healthy volunteers was compared with that of 18 patients with ischemic heart disease and concomitant hypertension. Liquid chromatography-mass-spectrometry (LC-MS) analysis of the second fraction of morning urine was carried out using nano-line high performance liquid chromatograph and hybrid mass spectrometer. The analysis revealed 23 proteins expressed in the endothelium, according to the information contained in the database Bgee, and 49 proteins, with direct functional link with the processes in the endothelium in the reconstruction of associative networks using ANDSystem program. Comparison of urine proteome of healthy people and patients with postinfarction cardiosclerosis revealed proteins specific for patients with cardiovascular disease. Thus, proteins vitronectin, syndecan-4, a histidine rich glycoprotein, endothelial protein C receptor, colony stimulating factor, cathepsin D and sekretogranin-1 may be considered as potential markers for cardiovascular diseases. Further research in this area should be conducted for clinical and experimental verification of these hypotheses.</abstract><cop>Russia (Federation)</cop><pmid>29276918</pmid><doi>10.10087/cardio.2017.11.10054</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-9040 |
| ispartof | Kardiologiia, 2017-11, Vol.57 (11), p.49-58 |
| issn | 0022-9040 |
| language | rus |
| recordid | cdi_proquest_miscellaneous_1980534999 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| title | Analysis of Urine Proteome in Patients With Postinfarction Cardiosclerosis Combined With Hypertensive Disease for Assessing Endothelial Dysfunction |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T12%3A37%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Analysis%20of%20Urine%20Proteome%20in%20Patients%20With%20Postinfarction%20Cardiosclerosis%20Combined%20With%20Hypertensive%20Disease%20for%20Assessing%20Endothelial%20Dysfunction&rft.jtitle=Kardiologiia&rft.au=Masenko,%20V%20P&rft.date=2017-11&rft.volume=57&rft.issue=11&rft.spage=49&rft.epage=58&rft.pages=49-58&rft.issn=0022-9040&rft_id=info:doi/10.10087/cardio.2017.11.10054&rft_dat=%3Cproquest_pubme%3E1980534999%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1980534999&rft_id=info:pmid/29276918&rfr_iscdi=true |