Chemopreventative effect of a cyclooxygenase-2-specific inhibitor (etodolac) on chemically induced biliary carcinogenesis in hamsters

The present study was designed to evaluate whether etodolac, a cyclooxgenase-2 (COX-2)-specific inhibitor, could prevent chemically induced biliary carcinogenesis in bilioenterostomized hamsters. Syrian golden hamsters were subjected to choledochojejunostomy and then received subcutaneous injections...

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Veröffentlicht in:	Carcinogenesis (New York) 2005-02, Vol.26 (2), p.465-469
Hauptverfasser:	Tsuneoka, Noritsugu, Tajima, Yoshitsugu, Kitazato, Amane, Fukuda, Kenzo, Kitajima, Tomoo, Kuroki, Tamotsu, Onizuka, Shinya, Kanematsu, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biliary Tract Neoplasms - chemically induced Biliary Tract Neoplasms - pathology Biliary Tract Neoplasms - prevention & control Biological and medical sciences BOP Carcinogenesis, carcinogens and anticarcinogens Carcinoma - chemically induced Carcinoma - pathology Carcinoma - prevention & control Choledochostomy - methods COX-2 Cricetinae cyclooxgenase-2 Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors - administration & dosage Cyclooxygenase Inhibitors - adverse effects Cyclooxygenase Inhibitors - pharmacology Dinoprostone - metabolism Etodolac - administration & dosage Etodolac - adverse effects Etodolac - pharmacology Female Liver - drug effects Liver - enzymology Liver - pathology Medical sciences Mesocricetus N-nitrosobis (2-oxopropyl) amine Nitrosamines - toxicity non-steroidal anti-inflammatory drugs NSAIDs Pancreas - drug effects Pancreas - enzymology Pancreas - pathology PCNA-LI PGE2 proliferating cell nuclear antigen labeling index prostaglandin E2 Prostaglandin-Endoperoxide Synthases - metabolism Tumors
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