Inactivation of the Glucose-Dependent Insulinotropic Polypeptide Receptor Improves Outcomes following Experimental Myocardial Infarction

Incretin hormones exert pleiotropic metabolic actions beyond the pancreas. Although the heart expresses both incretin receptors, the cardiac biology of GIP receptor (GIPR) action remains incompletely understood. Here we show that GIPR agonism did not impair the response to cardiac ischemia. In contr...

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Veröffentlicht in:	Cell metabolism 2018-02, Vol.27 (2), p.450-460.e6
Hauptverfasser:	Ussher, John R., Campbell, Jonathan E., Mulvihill, Erin E., Baggio, Laurie L., Bates, Holly E., McLean, Brent A., Gopal, Keshav, Capozzi, Megan, Yusta, Bernardo, Cao, Xiemin, Ali, Safina, Kim, Minsuk, Kabir, M. Golam, Seino, Yutaka, Suzuki, Jinya, Drucker, Daniel J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - metabolism Animals cardiovascular diabetes Enzyme Activation G-protein-coupled receptor Gastric Inhibitory Polypeptide - metabolism glucose-dependent insulinotropic polypeptide gut peptide Heart Failure - pathology HEK293 Cells hormone sensitive lipase Humans incretin ischemia MAP Kinase Signaling System Mice Mice, Inbred C57BL myocardial infarction Myocardial Infarction - diagnostic imaging Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardial Infarction - prevention & control Myocardium - metabolism Myocardium - pathology Myocytes, Cardiac - metabolism obesity Phosphorylation Receptors, Gastrointestinal Hormone - deficiency Receptors, Gastrointestinal Hormone - genetics Receptors, Gastrointestinal Hormone - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction Sterol Esterase - metabolism Triglycerides - metabolism Ventricular Remodeling
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