Genotoxicity testing of aqueous extracts of Mahwangyounpae-tang, a polyherbal formula
Mahwangyounpae-tang (MT), consisting of 22 types of herbal extracts has been used for thousands of years in Korean traditional medicine for the oral treatment of respiratory diseases including asthma. As part of a safety evaluation of MT extracts for use in asthma, the potential genotoxicity of an a...
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| Veröffentlicht in: | Food and chemical toxicology 2008-12, Vol.46 (12), p.3827-3831 |
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| container_title | Food and chemical toxicology |
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| creator | Seo, Jeng-Yim Park, Mee-Yeon Jung, Tae-Young Choi, Hae-Yun Kim, Jong-Dae Lee, Hyeung-Sik Ku, Sae-Kwang |
| description | Mahwangyounpae-tang (MT), consisting of 22 types of herbal extracts has been used for thousands of years in Korean traditional medicine for the oral treatment of respiratory diseases including asthma. As part of a safety evaluation of MT extracts for use in asthma, the potential genotoxicity of an aqueous MT extract was evaluated using the standard battery of tests (bacterial reverse mutation assay; chromosomal aberrations assay; mouse micronucleus assay) recommended by Korea Food and Drug Administration (KFDA). The MT extract was determined not to be genotoxic under the conditions of the reverse mutation assay, chromosomal aberrations assay and mouse micronucleus assay. Use of MT is presently expected to be safe, as anticipated intake is small compared to the doses administered in the genotoxicity assays and may, after further toxicity research, prove to be a useful anti-asthma agent. |
| doi_str_mv | 10.1016/j.fct.2008.10.005 |
| format | Article |
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As part of a safety evaluation of MT extracts for use in asthma, the potential genotoxicity of an aqueous MT extract was evaluated using the standard battery of tests (bacterial reverse mutation assay; chromosomal aberrations assay; mouse micronucleus assay) recommended by Korea Food and Drug Administration (KFDA). The MT extract was determined not to be genotoxic under the conditions of the reverse mutation assay, chromosomal aberrations assay and mouse micronucleus assay. Use of MT is presently expected to be safe, as anticipated intake is small compared to the doses administered in the genotoxicity assays and may, after further toxicity research, prove to be a useful anti-asthma agent.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/j.fct.2008.10.005</identifier><identifier>PMID: 18957314</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>animal models ; Animals ; Anti-Asthmatic Agents - toxicity ; asthma ; bacteria ; Biological and medical sciences ; Chromosomal aberration assay ; chromosome aberrations ; Chromosome Aberrations - drug effects ; DNA damage ; DNA fragmentation ; Extracts ; genotoxicity ; herbal medicines ; herbs ; Mahwangyounpae-tang ; Medical sciences ; medicinal plants ; Medicine, Korean Traditional ; Mice ; Mice, Inbred ICR ; Micronucleus Tests ; Mouse micronucleus assay ; mutagenicity ; Mutagenicity Tests ; Mutagens - toxicity ; mutation ; Oriental traditional medicine ; plant extracts ; Plant Extracts - toxicity ; polyherb ; Rats ; Reverse mutation assay ; toxicity testing ; Toxicology ; Water</subject><ispartof>Food and chemical toxicology, 2008-12, Vol.46 (12), p.3827-3831</ispartof><rights>2008 Elsevier Ltd</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-a541d49fdc8bb29bf3614b2d12e1055da2f3da05ee1d7796f2f8075b22a45e8f3</citedby><cites>FETCH-LOGICAL-c436t-a541d49fdc8bb29bf3614b2d12e1055da2f3da05ee1d7796f2f8075b22a45e8f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.fct.2008.10.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20919101$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18957314$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seo, Jeng-Yim</creatorcontrib><creatorcontrib>Park, Mee-Yeon</creatorcontrib><creatorcontrib>Jung, Tae-Young</creatorcontrib><creatorcontrib>Choi, Hae-Yun</creatorcontrib><creatorcontrib>Kim, Jong-Dae</creatorcontrib><creatorcontrib>Lee, Hyeung-Sik</creatorcontrib><creatorcontrib>Ku, Sae-Kwang</creatorcontrib><title>Genotoxicity testing of aqueous extracts of Mahwangyounpae-tang, a polyherbal formula</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>Mahwangyounpae-tang (MT), consisting of 22 types of herbal extracts has been used for thousands of years in Korean traditional medicine for the oral treatment of respiratory diseases including asthma. As part of a safety evaluation of MT extracts for use in asthma, the potential genotoxicity of an aqueous MT extract was evaluated using the standard battery of tests (bacterial reverse mutation assay; chromosomal aberrations assay; mouse micronucleus assay) recommended by Korea Food and Drug Administration (KFDA). The MT extract was determined not to be genotoxic under the conditions of the reverse mutation assay, chromosomal aberrations assay and mouse micronucleus assay. Use of MT is presently expected to be safe, as anticipated intake is small compared to the doses administered in the genotoxicity assays and may, after further toxicity research, prove to be a useful anti-asthma agent.</description><subject>animal models</subject><subject>Animals</subject><subject>Anti-Asthmatic Agents - toxicity</subject><subject>asthma</subject><subject>bacteria</subject><subject>Biological and medical sciences</subject><subject>Chromosomal aberration assay</subject><subject>chromosome aberrations</subject><subject>Chromosome Aberrations - drug effects</subject><subject>DNA damage</subject><subject>DNA fragmentation</subject><subject>Extracts</subject><subject>genotoxicity</subject><subject>herbal medicines</subject><subject>herbs</subject><subject>Mahwangyounpae-tang</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>Medicine, Korean Traditional</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Micronucleus Tests</subject><subject>Mouse micronucleus assay</subject><subject>mutagenicity</subject><subject>Mutagenicity Tests</subject><subject>Mutagens - toxicity</subject><subject>mutation</subject><subject>Oriental traditional medicine</subject><subject>plant extracts</subject><subject>Plant Extracts - toxicity</subject><subject>polyherb</subject><subject>Rats</subject><subject>Reverse mutation assay</subject><subject>toxicity testing</subject><subject>Toxicology</subject><subject>Water</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFv1DAQhS0EotvCD-ACudATWWwnjmP1hCooSEUcYM_WxB5vvcrGi-1A99_jaFdwQ7I09sw3z0-PkFeMrhll3fvd2pm85pT25b2mVDwhK9bLpu4awZ6SFeWyrzvFxAW5TGlHKZVMds_JBeuVkA1rV2Rzh1PI4dEbn49VxpT9tK2Cq-DnjGFOFT7mCCanpfcVHn7DtD2GeToA1rnc31VQHcJ4fMA4wFi5EPfzCC_IMwdjwpfnekU2nz7-uP1c33-7-3L74b42bdPlGkTLbKucNf0wcDW4pmPtwC3jyKgQFrhrLFCByKyUqnPc9VSKgXNoBfauuSLXJ91DDMVvynrvk8FxhGkxr5mSqhxRQHYCTQwpRXT6EP0e4lEzqpcs9U6XLPWS5dIqWZad12fxedij_bdxDq8Ab88AJAOjizAZn_5ynCqminbh3pw4B0HDNhZm852XQfmXFqWuEDcnAktYvzxGnYzHyaD1EYstG_x_jP4Bz5ebuw</recordid><startdate>20081201</startdate><enddate>20081201</enddate><creator>Seo, Jeng-Yim</creator><creator>Park, Mee-Yeon</creator><creator>Jung, Tae-Young</creator><creator>Choi, Hae-Yun</creator><creator>Kim, Jong-Dae</creator><creator>Lee, Hyeung-Sik</creator><creator>Ku, Sae-Kwang</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20081201</creationdate><title>Genotoxicity testing of aqueous extracts of Mahwangyounpae-tang, a polyherbal formula</title><author>Seo, Jeng-Yim ; Park, Mee-Yeon ; Jung, Tae-Young ; Choi, Hae-Yun ; Kim, Jong-Dae ; Lee, Hyeung-Sik ; Ku, Sae-Kwang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-a541d49fdc8bb29bf3614b2d12e1055da2f3da05ee1d7796f2f8075b22a45e8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>animal models</topic><topic>Animals</topic><topic>Anti-Asthmatic Agents - toxicity</topic><topic>asthma</topic><topic>bacteria</topic><topic>Biological and medical sciences</topic><topic>Chromosomal aberration assay</topic><topic>chromosome aberrations</topic><topic>Chromosome Aberrations - drug effects</topic><topic>DNA damage</topic><topic>DNA fragmentation</topic><topic>Extracts</topic><topic>genotoxicity</topic><topic>herbal medicines</topic><topic>herbs</topic><topic>Mahwangyounpae-tang</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>Medicine, Korean Traditional</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Micronucleus Tests</topic><topic>Mouse micronucleus assay</topic><topic>mutagenicity</topic><topic>Mutagenicity Tests</topic><topic>Mutagens - toxicity</topic><topic>mutation</topic><topic>Oriental traditional medicine</topic><topic>plant extracts</topic><topic>Plant Extracts - toxicity</topic><topic>polyherb</topic><topic>Rats</topic><topic>Reverse mutation assay</topic><topic>toxicity testing</topic><topic>Toxicology</topic><topic>Water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seo, Jeng-Yim</creatorcontrib><creatorcontrib>Park, Mee-Yeon</creatorcontrib><creatorcontrib>Jung, Tae-Young</creatorcontrib><creatorcontrib>Choi, Hae-Yun</creatorcontrib><creatorcontrib>Kim, Jong-Dae</creatorcontrib><creatorcontrib>Lee, Hyeung-Sik</creatorcontrib><creatorcontrib>Ku, Sae-Kwang</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seo, Jeng-Yim</au><au>Park, Mee-Yeon</au><au>Jung, Tae-Young</au><au>Choi, Hae-Yun</au><au>Kim, Jong-Dae</au><au>Lee, Hyeung-Sik</au><au>Ku, Sae-Kwang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genotoxicity testing of aqueous extracts of Mahwangyounpae-tang, a polyherbal formula</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>2008-12-01</date><risdate>2008</risdate><volume>46</volume><issue>12</issue><spage>3827</spage><epage>3831</epage><pages>3827-3831</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>Mahwangyounpae-tang (MT), consisting of 22 types of herbal extracts has been used for thousands of years in Korean traditional medicine for the oral treatment of respiratory diseases including asthma. As part of a safety evaluation of MT extracts for use in asthma, the potential genotoxicity of an aqueous MT extract was evaluated using the standard battery of tests (bacterial reverse mutation assay; chromosomal aberrations assay; mouse micronucleus assay) recommended by Korea Food and Drug Administration (KFDA). The MT extract was determined not to be genotoxic under the conditions of the reverse mutation assay, chromosomal aberrations assay and mouse micronucleus assay. Use of MT is presently expected to be safe, as anticipated intake is small compared to the doses administered in the genotoxicity assays and may, after further toxicity research, prove to be a useful anti-asthma agent.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>18957314</pmid><doi>10.1016/j.fct.2008.10.005</doi><tpages>5</tpages></addata></record> |
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| subjects | animal models Animals Anti-Asthmatic Agents - toxicity asthma bacteria Biological and medical sciences Chromosomal aberration assay chromosome aberrations Chromosome Aberrations - drug effects DNA damage DNA fragmentation Extracts genotoxicity herbal medicines herbs Mahwangyounpae-tang Medical sciences medicinal plants Medicine, Korean Traditional Mice Mice, Inbred ICR Micronucleus Tests Mouse micronucleus assay mutagenicity Mutagenicity Tests Mutagens - toxicity mutation Oriental traditional medicine plant extracts Plant Extracts - toxicity polyherb Rats Reverse mutation assay toxicity testing Toxicology Water |
| title | Genotoxicity testing of aqueous extracts of Mahwangyounpae-tang, a polyherbal formula |
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