Versatile T1‑Based Chemical Analysis Platform Using Fe3+/Fe2+ Interconversion

Versatile T1‑Based Chemical Analysis Platform Using Fe3+/Fe2+ Interconversion

We report a versatile analytical platform for assaying multiple analytes relying on changes in longitudinal relaxation time (T1) as a result of Fe3+/Fe2+ interconversion. The T1 of water protons in Fe3+ aqueous solution differs significantly from that of Fe2+, allowing for the development of a gener...

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Veröffentlicht in:Analytical chemistry (Washington) 2018-01, Vol.90 (2), p.1234-1240
Hauptverfasser: Chen, Yiping, Yin, Binfeng, Dong, Mingling, Xianyu, Yunlei, Jiang, Xingyu
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creator Chen, Yiping
Yin, Binfeng
Dong, Mingling
Xianyu, Yunlei
Jiang, Xingyu
description We report a versatile analytical platform for assaying multiple analytes relying on changes in longitudinal relaxation time (T1) as a result of Fe3+/Fe2+ interconversion. The T1 of water protons in Fe3+ aqueous solution differs significantly from that of Fe2+, allowing for the development of a generally applicable T1-based assay since many redox reactions enable the interconversion between Fe2+ and Fe3+ that can result in the change of T1. Compared with conventional magnetic biosensors, this T1-based assay is free of magnetic nanoparticles (MNPs), and the stability of T1-based assay is better than conventional magnetic sensors that suffer from nonspecific adsorption and aggregation of MNPs. This T1-based assay simultaneously enables “one-step mixing” assays (such as saliva sugar) and “multiple-washing” immunoassays with good stability and sensitivity, offering a promising platform for convenient, stable, and versatile biomedical analysis
doi_str_mv 10.1021/acs.analchem.7b03961
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