Anomalous Properties of Lys Residues Buried in the Hydrophobic Interior of a Protein Revealed with 15N‑Detect NMR Spectroscopy

Ionizable residues buried in hydrophobic environments in proteins are essential for many fundamental biochemical processes. These residues titrate with anomalous pK a values that are challenging to reproduce with structure-based calculations owing to the conformational reorganization coupled to thei...

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Veröffentlicht in:	The journal of physical chemistry letters 2018-01, Vol.9 (2), p.383-387
Hauptverfasser:	Kougentakis, Christos M, Grasso, Emily M, Robinson, Aaron C, Caro, José A, Schlessman, Jamie L, Majumdar, Ananya, García-Moreno E, Bertrand
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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