Circulating triacylglycerols but not pancreatic fat associate with insulin secretion in healthy humans
Loss of adequate insulin secretion for the prevailing insulin resistance is critical for the development of type 2 diabetes and has been suggested to result from circulating lipids (triacylglycerols [TG] or free fatty acids) and/or adipocytokines or from ectopic lipid storage in the pancreas. This s...
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| Veröffentlicht in: | Metabolism, clinical and experimental clinical and experimental, 2018-04, Vol.81, p.113-125 |
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| creator | Nowotny, Bettina Kahl, Sabine Klüppelholz, Birgit Hoffmann, Barbara Giani, Guido Livingstone, Roshan Nowotny, Peter J. Stamm, Valerie Herder, Christian Tura, Andrea Pacini, Giovanni Hwang, Jong-Hee Roden, Michael |
| description | Loss of adequate insulin secretion for the prevailing insulin resistance is critical for the development of type 2 diabetes and has been suggested to result from circulating lipids (triacylglycerols [TG] or free fatty acids) and/or adipocytokines or from ectopic lipid storage in the pancreas. This study aimed to address whether circulating lipids, adipocytokines or pancreatic fat primarily associates with lower insulin secretion.
Nondiabetic persons (n=73), recruited from the general population, underwent clinical examinations, fasting blood drawing to measure TG and adipocytokines and oral glucose tolerance testing (OGTT) to assess basal and dynamic insulin secretion and sensitivity indices. Magnetic resonance imaging and 1H-magnetic resonance spectroscopy were used to measure body fat distribution and ectopic fat content in liver and pancreas.
In age-, sex- and BMI-adjusted analyses, total and high-molecular-weight adiponectin were the strongest negative predictors of fasting beta-cell function (BCF; β=−0.403, p=0.0003 and β=−0.237, p=0.01, respectively) and adaptation index (AI; β=−0.210, p=0.006 and β=−0.133, p=0.02, respectively). Circulating TG, but not pancreatic fat content, related positively to BCF (β=0.375, p |
| doi_str_mv | 10.1016/j.metabol.2017.12.005 |
| format | Article |
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Nondiabetic persons (n=73), recruited from the general population, underwent clinical examinations, fasting blood drawing to measure TG and adipocytokines and oral glucose tolerance testing (OGTT) to assess basal and dynamic insulin secretion and sensitivity indices. Magnetic resonance imaging and 1H-magnetic resonance spectroscopy were used to measure body fat distribution and ectopic fat content in liver and pancreas.
In age-, sex- and BMI-adjusted analyses, total and high-molecular-weight adiponectin were the strongest negative predictors of fasting beta-cell function (BCF; β=−0.403, p=0.0003 and β=−0.237, p=0.01, respectively) and adaptation index (AI; β=−0.210, p=0.006 and β=−0.133, p=0.02, respectively). Circulating TG, but not pancreatic fat content, related positively to BCF (β=0.375, p<0.0001) and AI (β=0.192, p=0.003). Similar results were obtained for the disposition index (DI).
The association of serum lipids and adiponectin with beta-cell function may represent a compensatory response to adapt for lower insulin sensitivity in nondiabetic humans.</description><identifier>ISSN: 0026-0495</identifier><identifier>EISSN: 1532-8600</identifier><identifier>DOI: 10.1016/j.metabol.2017.12.005</identifier><identifier>PMID: 29273469</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adiponectin ; Adiponectin - blood ; Aged ; Fatty acids ; Fatty Acids, Nonesterified - blood ; Female ; Humans ; Insulin - metabolism ; Insulin Resistance ; Insulin Secretion ; Insulin secretion in vivo ; Insulin-Secreting Cells - physiology ; Lipids - physiology ; Male ; Middle Aged ; Pancreatic fat ; Triacylglycerols ; Triglycerides - blood</subject><ispartof>Metabolism, clinical and experimental, 2018-04, Vol.81, p.113-125</ispartof><rights>2017 Elsevier Inc.</rights><rights>Copyright © 2017 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-70770a89a13bfdb5ac9f84bb609efa6f5498a4872a298fe44964f089234c6c103</citedby><cites>FETCH-LOGICAL-c365t-70770a89a13bfdb5ac9f84bb609efa6f5498a4872a298fe44964f089234c6c103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0026049517303426$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29273469$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nowotny, Bettina</creatorcontrib><creatorcontrib>Kahl, Sabine</creatorcontrib><creatorcontrib>Klüppelholz, Birgit</creatorcontrib><creatorcontrib>Hoffmann, Barbara</creatorcontrib><creatorcontrib>Giani, Guido</creatorcontrib><creatorcontrib>Livingstone, Roshan</creatorcontrib><creatorcontrib>Nowotny, Peter J.</creatorcontrib><creatorcontrib>Stamm, Valerie</creatorcontrib><creatorcontrib>Herder, Christian</creatorcontrib><creatorcontrib>Tura, Andrea</creatorcontrib><creatorcontrib>Pacini, Giovanni</creatorcontrib><creatorcontrib>Hwang, Jong-Hee</creatorcontrib><creatorcontrib>Roden, Michael</creatorcontrib><title>Circulating triacylglycerols but not pancreatic fat associate with insulin secretion in healthy humans</title><title>Metabolism, clinical and experimental</title><addtitle>Metabolism</addtitle><description>Loss of adequate insulin secretion for the prevailing insulin resistance is critical for the development of type 2 diabetes and has been suggested to result from circulating lipids (triacylglycerols [TG] or free fatty acids) and/or adipocytokines or from ectopic lipid storage in the pancreas. This study aimed to address whether circulating lipids, adipocytokines or pancreatic fat primarily associates with lower insulin secretion.
Nondiabetic persons (n=73), recruited from the general population, underwent clinical examinations, fasting blood drawing to measure TG and adipocytokines and oral glucose tolerance testing (OGTT) to assess basal and dynamic insulin secretion and sensitivity indices. Magnetic resonance imaging and 1H-magnetic resonance spectroscopy were used to measure body fat distribution and ectopic fat content in liver and pancreas.
In age-, sex- and BMI-adjusted analyses, total and high-molecular-weight adiponectin were the strongest negative predictors of fasting beta-cell function (BCF; β=−0.403, p=0.0003 and β=−0.237, p=0.01, respectively) and adaptation index (AI; β=−0.210, p=0.006 and β=−0.133, p=0.02, respectively). Circulating TG, but not pancreatic fat content, related positively to BCF (β=0.375, p<0.0001) and AI (β=0.192, p=0.003). Similar results were obtained for the disposition index (DI).
The association of serum lipids and adiponectin with beta-cell function may represent a compensatory response to adapt for lower insulin sensitivity in nondiabetic humans.</description><subject>Adiponectin</subject><subject>Adiponectin - blood</subject><subject>Aged</subject><subject>Fatty acids</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Insulin - metabolism</subject><subject>Insulin Resistance</subject><subject>Insulin Secretion</subject><subject>Insulin secretion in vivo</subject><subject>Insulin-Secreting Cells - physiology</subject><subject>Lipids - physiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pancreatic fat</subject><subject>Triacylglycerols</subject><subject>Triglycerides - blood</subject><issn>0026-0495</issn><issn>1532-8600</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9vFCEYh0mjsdvWj1DD0cuMwDAMnIzZqDVp4kXPhGFfumwYWIHR7Lcvza5ePb3Jm-f3_nkQuqekp4SKD4d-gWrmFHpG6NRT1hMyXqENHQfWSUHIK7QhhImOcDVeo5tSDoSQaZLiDbpmik0DF2qD3NZnuwZTfXzCNXtjT-EpnCzkFAqe14pjqvhoos3QIIudqdiUkqw3FfAfX_fYx7IGH3GBBlWfYuvgPZhQ9ye8XxcTyx167Uwo8PZSb9HPL59_bB-6x-9fv20_PXZ2EGPtpnYgMVIZOsxuN4_GKif5PAuiwBnhRq6k4XJihinpgHMluCNSsYFbYSkZbtH789xjTr9WKFUvvlgIwURIa9FUTUoJJvnU0PGM2pxKyeD0MfvF5JOmRL8o1gd9UaxfFGvKdFPccu8uK9Z5gd2_1F-nDfh4BqA9-ttD1sV6iBZ2PoOtepf8f1Y8A6SgkaQ</recordid><startdate>201804</startdate><enddate>201804</enddate><creator>Nowotny, Bettina</creator><creator>Kahl, Sabine</creator><creator>Klüppelholz, Birgit</creator><creator>Hoffmann, Barbara</creator><creator>Giani, Guido</creator><creator>Livingstone, Roshan</creator><creator>Nowotny, Peter J.</creator><creator>Stamm, Valerie</creator><creator>Herder, Christian</creator><creator>Tura, Andrea</creator><creator>Pacini, Giovanni</creator><creator>Hwang, Jong-Hee</creator><creator>Roden, Michael</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201804</creationdate><title>Circulating triacylglycerols but not pancreatic fat associate with insulin secretion in healthy humans</title><author>Nowotny, Bettina ; Kahl, Sabine ; Klüppelholz, Birgit ; Hoffmann, Barbara ; Giani, Guido ; Livingstone, Roshan ; Nowotny, Peter J. ; Stamm, Valerie ; Herder, Christian ; Tura, Andrea ; Pacini, Giovanni ; Hwang, Jong-Hee ; Roden, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-70770a89a13bfdb5ac9f84bb609efa6f5498a4872a298fe44964f089234c6c103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adiponectin</topic><topic>Adiponectin - blood</topic><topic>Aged</topic><topic>Fatty acids</topic><topic>Fatty Acids, Nonesterified - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Insulin - metabolism</topic><topic>Insulin Resistance</topic><topic>Insulin Secretion</topic><topic>Insulin secretion in vivo</topic><topic>Insulin-Secreting Cells - physiology</topic><topic>Lipids - physiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pancreatic fat</topic><topic>Triacylglycerols</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nowotny, Bettina</creatorcontrib><creatorcontrib>Kahl, Sabine</creatorcontrib><creatorcontrib>Klüppelholz, Birgit</creatorcontrib><creatorcontrib>Hoffmann, Barbara</creatorcontrib><creatorcontrib>Giani, Guido</creatorcontrib><creatorcontrib>Livingstone, Roshan</creatorcontrib><creatorcontrib>Nowotny, Peter J.</creatorcontrib><creatorcontrib>Stamm, Valerie</creatorcontrib><creatorcontrib>Herder, Christian</creatorcontrib><creatorcontrib>Tura, Andrea</creatorcontrib><creatorcontrib>Pacini, Giovanni</creatorcontrib><creatorcontrib>Hwang, Jong-Hee</creatorcontrib><creatorcontrib>Roden, Michael</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolism, clinical and experimental</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nowotny, Bettina</au><au>Kahl, Sabine</au><au>Klüppelholz, Birgit</au><au>Hoffmann, Barbara</au><au>Giani, Guido</au><au>Livingstone, Roshan</au><au>Nowotny, Peter J.</au><au>Stamm, Valerie</au><au>Herder, Christian</au><au>Tura, Andrea</au><au>Pacini, Giovanni</au><au>Hwang, Jong-Hee</au><au>Roden, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating triacylglycerols but not pancreatic fat associate with insulin secretion in healthy humans</atitle><jtitle>Metabolism, clinical and experimental</jtitle><addtitle>Metabolism</addtitle><date>2018-04</date><risdate>2018</risdate><volume>81</volume><spage>113</spage><epage>125</epage><pages>113-125</pages><issn>0026-0495</issn><eissn>1532-8600</eissn><abstract>Loss of adequate insulin secretion for the prevailing insulin resistance is critical for the development of type 2 diabetes and has been suggested to result from circulating lipids (triacylglycerols [TG] or free fatty acids) and/or adipocytokines or from ectopic lipid storage in the pancreas. This study aimed to address whether circulating lipids, adipocytokines or pancreatic fat primarily associates with lower insulin secretion.
Nondiabetic persons (n=73), recruited from the general population, underwent clinical examinations, fasting blood drawing to measure TG and adipocytokines and oral glucose tolerance testing (OGTT) to assess basal and dynamic insulin secretion and sensitivity indices. Magnetic resonance imaging and 1H-magnetic resonance spectroscopy were used to measure body fat distribution and ectopic fat content in liver and pancreas.
In age-, sex- and BMI-adjusted analyses, total and high-molecular-weight adiponectin were the strongest negative predictors of fasting beta-cell function (BCF; β=−0.403, p=0.0003 and β=−0.237, p=0.01, respectively) and adaptation index (AI; β=−0.210, p=0.006 and β=−0.133, p=0.02, respectively). Circulating TG, but not pancreatic fat content, related positively to BCF (β=0.375, p<0.0001) and AI (β=0.192, p=0.003). Similar results were obtained for the disposition index (DI).
The association of serum lipids and adiponectin with beta-cell function may represent a compensatory response to adapt for lower insulin sensitivity in nondiabetic humans.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29273469</pmid><doi>10.1016/j.metabol.2017.12.005</doi><tpages>13</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adiponectin Adiponectin - blood Aged Fatty acids Fatty Acids, Nonesterified - blood Female Humans Insulin - metabolism Insulin Resistance Insulin Secretion Insulin secretion in vivo Insulin-Secreting Cells - physiology Lipids - physiology Male Middle Aged Pancreatic fat Triacylglycerols Triglycerides - blood |
| title | Circulating triacylglycerols but not pancreatic fat associate with insulin secretion in healthy humans |
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