Is defect in phosphorylation of Nbs1 responsible for high radiosensitivity of T-lymphocyte leukemia cells MOLT-4?

Abstract Mutations in NBS1 gene are related to higher occurrence of malignancies. In this work we studied response of T-lymphocyte leukemia cells MOLT-4 to ionizing radiation. We detected IRIF (ionizing radiation forming foci) containing histone γH2A.X, protein 53BP1, and Nbs1, which were formed aro...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Leukemia research 2008-08, Vol.32 (8), p.1259-1267
Hauptverfasser:	Rezacova, Martina, Tichy, Ales, Vavrova, Jirina, Vokurkova, Doris, Lukasova, Emilie
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Cycle Proteins - metabolism Cell Line, Tumor DNA Damage DNA Repair Dose-Response Relationship, Radiation H2A.X Hematology, Oncology and Palliative Medicine Humans Leukemia Leukemia, T-Cell - metabolism Leukemia, T-Cell - radiotherapy MOLT-4 Nbs1 Nuclear Proteins - metabolism Phosphorylation Radiation Radiation Tolerance
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!