A soluble CAR-SCF fusion protein improves adenoviral vector-mediated gene transferto c-Kit-positive hematopoietic cells

Background Although adenoviral vectors primarily derived from the adenovirus serotype 5 (Ad5) are widely used for many gene transfer applications, they cannot efficiently infect hematopoietic cells, since these cells do not express the coxsackie‐adenoviral receptor (CAR). Methods We have developed a...

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Veröffentlicht in:	The journal of gene medicine 2003-11, Vol.5 (11), p.929-940
Hauptverfasser:	Itoh, Akira, Okada, Takashi, Mizuguchi, Hiroyuki, Hayakawa, Takao, Mizukami, Hiroaki, Kume, Akihiro, Takatoku, Masaaki, Komatsu, Norio, Hanazono, Yutaka, Ozawa, Keiya
Format:	Artikel
Sprache:	eng
Schlagworte:	adapter Adenovirus c-Kit Gene therapy hematopoietic cell
Online-Zugang:	Volltext
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