The GCN4 bZIP can bind to noncognate gene regulatory sequences

We show that a minimalist basic region/leucine zipper (bZIP) hybrid, comprising the yeast GCN4 basic region and C/EBP leucine zipper, can target mammalian and other gene regulatory sequences naturally targeted by other bZIP and basic/helix–loop–helix (bHLH) proteins. We previously reported that this...

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Veröffentlicht in:	Biochimica et biophysica acta 2006-07, Vol.1764 (7), p.1252-1259
Hauptverfasser:	Fedorova, Anna V., Chan, I-San, Shin, Jumi A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aryl Hydrocarbon Receptor Nuclear Translocator - genetics Base Sequence Basic-Leucine Zipper Transcription Factors - chemistry Basic-Leucine Zipper Transcription Factors - genetics Basic-Leucine Zipper Transcription Factors - metabolism Binding Sites - genetics bZIP C/EBP CCAAT-Enhancer-Binding Proteins - genetics DNA - chemistry DNA - genetics DNA - metabolism DNA Footprinting DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism E-Box Elements - genetics Electrophoretic Mobility Shift Assay Enhancer box E-box GCN4 HIF response element HRE Hypoxia-Inducible Factor 1, alpha Subunit - genetics Models, Molecular Protein Binding Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism Regulatory Sequences, Nucleic Acid - genetics Response Elements - genetics Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Transcription Factor AP-1 - genetics Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism Xenobiotic response element XRE1
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