Memory T Cell Proliferation before Hepatitis C Virus Therapy Predicts Antiviral Immune Responses and Treatment Success

The contribution of the host immune system to the efficacy of new anti-hepatitis C virus (HCV) drugs is unclear. We undertook a longitudinal prospective study of 33 individuals with chronic HCV treated with combination pegylated IFN-α, ribavirin, and telaprevir/boceprevir. We characterized innate an...

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Veröffentlicht in:	The Journal of immunology (1950) 2018-02, Vol.200 (3), p.1124-1132
Hauptverfasser:	Méndez-Lagares, Gema, Lu, Ding, Chen, Connie, Terrault, Norah, Segal, Mark R, Khalili, Mandana, Monto, Alexander, Shen, Hui, Manos, M Michele, Lanier, Lewis L, Ryan, James C, McCune, Joseph M, Hartigan-O'Connor, Dennis J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Adaptive Immunity - immunology Antibodies, Viral - blood Antiviral agents Antiviral Agents - therapeutic use CD4-Positive T-Lymphocytes - immunology Cell activation Cell growth Cell Proliferation Cytotoxicity Drug Therapy, Combination Female Hepacivirus - immunology Hepatitis Hepatitis C Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - immunology Humans Immune response Immune system Immunity, Innate - immunology Immunologic Memory - immunology Immunological memory Immunosuppressive agents Interferon Interferon-alpha - therapeutic use Kinetics Longitudinal Studies Lymphocyte Activation - immunology Lymphocytes T Male Middle Aged Monocytes Oligopeptides - therapeutic use Polyethylene Glycols - therapeutic use Proline - analogs & derivatives Proline - therapeutic use Prospective Studies Recombinant Proteins - therapeutic use Ribavirin Ribavirin - therapeutic use T-Box Domain Proteins - biosynthesis Treatment Outcome Viruses α-Interferon
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