Myasthenia gravis: the role of complement at the neuromuscular junction

Generalized myasthenia gravis (gMG) is a rare autoimmune disorder characterized by skeletal muscle weakness caused by disrupted neurotransmission at the neuromuscular junction (NMJ). Approximately 74–88% of patients with gMG have acetylcholine receptor (AChR) autoantibodies. Complement plays an impo...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2018-01, Vol.1412 (1), p.113-128
1. Verfasser:	Howard, James F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors Animal models Autoantibodies Cell membranes Complement Complement activation Complement component C5 Damage prevention eculizumab Immunity Inhibition Lipophilic Membranes Monoclonal antibodies Muscles Myasthenia Myasthenia gravis myasthenia gravis, neuromuscular junction Neuromuscular junctions Neurotransmission Patients Proteins safety factor Skeletal muscle
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