The STAT3-IL-10-IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury

The disposal of apoptotic bodies by professional phagocytes is crucial to effective inflammation resolution. Our ability to improve the disposal of apoptotic bodies by professional phagocytes is impaired by a limited understanding of the molecular mechanisms that regulate the engulfment and digestio...

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Veröffentlicht in:	The Journal of immunology (1950) 2018-02, Vol.200 (3), p.1169-1187
Hauptverfasser:	Campana, Lara, Starkey Lewis, Philip J, Pellicoro, Antonella, Aucott, Rebecca L, Man, Janet, O'Duibhir, Eoghan, Mok, Sarah E, Ferreira-Gonzalez, Sofia, Livingstone, Eilidh, Greenhalgh, Stephen N, Hull, Katherine L, Kendall, Timothy J, Vernimmen, Douglas, Henderson, Neil C, Boulter, Luke, Gregory, Christopher D, Feng, Yi, Anderton, Stephen M, Forbes, Stuart J, Iredale, John P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Apoptosis Apoptosis - immunology Fibrosis Humans Inflammation Interleukin 10 Interleukin 6 Interleukin-10 - metabolism Interleukin-6 - metabolism Liver Liver - injuries Liver - pathology Liver Cirrhosis - pathology Macrophages Macrophages - immunology Macrophages - transplantation Male Mice Mice, Inbred C57BL Mice, Knockout Molecular modelling Necrosis - immunology Phagocytes Phagocytosis - immunology Phenotypes Regeneration - physiology Stat3 protein STAT3 Transcription Factor - metabolism Zebrafish - embryology
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