Unexpected phenotypic effects of a transgene integration causing a knockout of the endogenous Contactin-5 gene in mice

Contactins (Cntn1-6) are a family of neuronal membrane proteins expressed in the brain. They are required for establishing cell-to-cell contacts between neurons and for the growth and maturation of the axons. In humans, structural genomic variations in the Contactin genes are implicated in neurodeve...

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Veröffentlicht in:	Transgenic research 2018-02, Vol.27 (1), p.1-13
Hauptverfasser:	Smirnov, Alexander V., Kontsevaya, Galina V., Feofanova, Natalia A., Anisimova, Margarita V., Serova, Irina A., Gerlinskaya, Lyudmila A., Battulin, Nariman R., Moshkin, Mikhail P., Serov, Oleg L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Animals Auditory defects Axons Biomedical and Life Sciences Biomedical Engineering/Biotechnology Blood flow Blood pressure Body Composition - genetics Body Composition - physiology Body mass CNTN5 gene Coding Codons Colony-stimulating factor Contactin Contactins - genetics Drinking - genetics Eating - genetics Exons Female Gene Expression Regulation Genetic Engineering Granulocyte-macrophage colony-stimulating factor Granulocyte-Macrophage Colony-Stimulating Factor - genetics Heart rate Humans Hypertension Hypertension - genetics Integration Life Sciences Macrophages Male Membrane proteins Mice Mice, Knockout Mice, Transgenic - genetics Microinjection Molecular Medicine Neurodevelopmental disorders Obesity Original Paper Phenotype Plant Genetics and Genomics Polymerase Chain Reaction Population genetics Population studies Proteins Reverse transcription Rodents Splicing Transgenes Transgenic mice Transgenics
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