Of Cells and Microparticles: Assets and Liabilities of HLA Antibody Detection

Of Cells and Microparticles: Assets and Liabilities of HLA Antibody Detection

ABSTRACTThe evolution of antibody detection from cell- to bead-based technology has positively impacted the ability to allocate organs in a safe and timely manner. The devil, of course, is in the details that delineate how these assays are performed and applied and to recognize that while there have...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Transplantation 2018-01, Vol.102 (1S Suppl 1), p.S1-S6
Hauptverfasser: Liwski, Robert S, Gebel, Howard M
Format: Artikel
Sprache:eng
Schlagworte:
Biomarkers - metabolism
Cell-Derived Microparticles - immunology
Histocompatibility Testing - methods
Histocompatibility Testing - standards
HLA Antigens - immunology
Humans
Isoantibodies - metabolism
Organ Transplantation
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:ABSTRACTThe evolution of antibody detection from cell- to bead-based technology has positively impacted the ability to allocate organs in a safe and timely manner. The devil, of course, is in the details that delineate how these assays are performed and applied and to recognize that while there have been some truly amazing technological advances (assets), they are still imperfect and subject to error (liabilities). This review identifies the strengths of HLA antibody assays, highlights their weaknesses and offers approaches for standardization.
ISSN:0041-1337
1534-6080
DOI:10.1097/TP.0000000000001818